利培酮

利培酮组锥体外系不良反应和内分泌改变的发生均明显高于阿立呱唑组（P均<0.05）。

The incidences of extra-pyramidal symptoms and endocrine change in Risperidone group were obviously higher than those in Aripiprazole group ( P < 0.05 ) .

结论：利培酮治疗AD及MID的精神病性等症状疗效肯定。

Conclusion : It is suggested that risperidone has definite efficacy on psychotic symptoms of AD and MID.

齐拉西酮与利培酮治疗精神分裂症疗效的Meta分析

Meta-analysis of the effectiveness of ziprasidone and risperidone in treatment of schizophrenia

采用HPLC方法测定治疗后4周及8周时利培酮及其代谢产物9&羟利培酮的血药浓度。

The drug concentration of risperidone and 9-OH-risperidone were detected by using HPLC at week 4 , 8 after the treatment .

利培酮联合抗抑郁药物治疗抑郁症对照研究的Meta分析

Meta-analysis of efficacy of risperidone in combination with antidepressant and single antidepressant in treatment of depression

TESS评定阿立哌唑组副作用小于利培酮组（P<0.01）。

TESS showed aripiprazole had less side effects than risperidone ( P < 0.01 ) .

影响利培酮治疗Tourette综合征疗效的多因素分析

The factors affecting therapeutic effect of risperidone in Tourette ′ s syndrome

利培酮治疗Tourette综合征对照研究

Controlled study of risperidone in treatment of Tourette syndrome

利培酮组治疗后TC，TG，LDLc升高不明显（P>0.05）。

Blood TC , TG , HDL-C , LDL-C levels in risperdal group was not significantly changed after the treatment ( P > 0.05 ) .

利培酮组的WAIS-RC、CT、CMS总分均明显高于氯丙嗪组，差异有显著性。

The total score of WAIS , CT and CMS were significantly higher in risperidone group than in chlorpromazine group .

精神分裂症ghrelin基因多态性与利培酮治疗前后血糖的变化

Relationship between polymorphism of ghrelin gene and the change of plasma glucose during risperidone treatment in schizophrenia patients

奎硫平及齐拉西酮对心电图QTc影响的研究奎硫平与利培酮治疗精神分裂症患者对照研究

Comparative Study of Electrocardiogram QTc between Seroquel and Ziprasidone in the Treatment of Schizophrenia

FDA称，强生公司的利培酮能用于治疗易激惹，包括包括攻击行为，蓄意自伤和发脾气。

The FDA said Johnson & Johnson 's Risperdal could be used to treat irritability , including aggression , deliberate self-injury and temper tantrums .

目的：了解利培酮治疗老年期精神障碍患者的用药特点、疗效及锥体外系反应（EPS）。

Objective : To know the application character , efficacy and extrapyramidal side effect ( EPS ) of risperidone in the treatment of late-life psychosis .

目的用氢氧化镁调节利培酮PLGA微球的释放速度。

Objective This paper focused on adjusting the release rates of risperidone from PLGA microspheres by co-encapsulating Mg ( OH ) 2 .

目的：进一步验证利培酮治疗Tourette综合征的疗效和不良反应。

Objective : To further testify the efficacy and side effects of risperidone in the treatment of Tourette syndrome .

目的：比较氯氮平、利培酮对精神分裂症患者血清催乳素（PRL）、三碘甲状腺原氨酸（T3）、甲状腺素（T4）的影响。

Objective : To study the effects of risperidone and clozapine on the serum prolactin , T 3 and T 4 levels .

目的探讨非典型抗精神病药利培酮对首发精神分裂症患者血浆催乳素（PRL）水平的影响及其与疗效的关系。

Objective To investigate the effect of atypical antipsychotic drug risperidone on the plasma prolactin level and their relationship with clinical efficacy .

目的探讨利培酮单一治疗难治性TS的临床疗效和安全性以及影响其疗效的关键因素。

OBJECTIVE The aim of this study was to determine the efficacy and safety of risperidone in the treatment of refractory TS and to explore the key factors affecting the therapeutic effect .

用利培酮治疗后，睡眠进程指标改善，睡眠阶段2的时间和比例增加，REM睡眠潜伏期增加，REM强度减少。

After six-week 's treatment with risperidone , patients exhibited improved sleep continuity , increased Sleep stage 2 time and percent , increased REM sleep latency and diminished REM intensity .

方法将84例老年器质性精神障碍患者随机分为3组，分别给予不同剂量利培酮0.5mg、1mg、2mg，疗程6周。

Methods 84 patients of elderly organic mental disorders were randomly assigned to 3 groups to receive risperidone of different dosage respectively for 6 weeks .

2及4mg组利培酮及其代谢产物9羟利培酮血药浓度存在显著差异，但疗效无显著性差异。

There was a significant difference in plasma drug level of risperidone and its metabolite between 2 mg and 4 mg groups but no significant difference in efficacy .

方法对20例难治性分裂情感性精神病患者给予利培酮治疗，疗程6w，随访6mo。

Methods 20 patients with refractory schizoaffective psychosis were treated with risperidone for 6 weeks and followed up for 6 months .

目的探讨利培酮对精神分裂症患者中枢多巴胺代谢产物血浆高香草酸（pHVA）的影响。

Objective To investigate the effect of risperidone on plasma homovanillic acid ( pHVA ) level in schizophrenics .

氯氮平组体质量平均增加2.5kg，利培酮组1.4kg；

Net weight was increased 2.5 kg in clozapine group and 1.4 kg in risperidone group .

结论精神分裂症患者存在IL2、IL6、IL8、TNFα介导的免疫功能紊乱，利培酮可能通过抑制IL2、IL6的生成而对精神分裂症的免疫功能紊乱进行纠正。

Conclusion The patients with schizophrenia have immune dysfunction mediated by IL-2 、 IL-6 、 IL-8 and TNF - α . Risperidone may have inhibitory regulation effect on the immune dysfunction .

方法38例难治性抑郁症患者在合并利培酮治疗前及治疗后4周末分别检测患者外周血血小板5-HT浓度，并评估汉密顿抑郁量表17项（HAMD17）、汉密顿焦虑量表（HAMA）。

Methods : Before and 4 weeks after risperidone was added , the serotonin concentrations were measured and Hamilton Depression Scale ( HAMD ) and Hamilton Anxiety Scale ( HAMA ) scores were rated for the 38 treatment-resistant depression patients .

方法：将首发精神分裂症患者按中医辨证分为痰湿内阻型，痰火内扰型及其他型，应用利培酮治疗，使用PANSS、TESS、WCST等评定工具观察疗效、副反应、认知改善情况。

Methods : Applying Risperidone to treat first episode schizophrenics who were divided into Phlegm-Dampness type , Phlegm-Fire type and other types in TCM , and observing them with PANSS , TESS and Wisconsin Card Sorting Test ( WCST ) .

两组均以窦性心动过速、窦性心律不齐和ST-T改变多见，但利培酮组窦性心动过速和ST-T改变发生率明显低于氯氮平组，而窦性心律不齐明显高于氯氮平组。

Sinus tachycardia , sinus arrhythmia and ST-T change were common in both the 2 groups , but incidence rate of sinus tachycardia or ST-T change were lower and that of sinus arrhythmia higher in the risperidone than in the clozapine group .

方法：对198例单用氯丙嗪或利培酮治疗的精神分裂症住院患者于治疗前、治疗1、2、3、6、12个月测定HbA1C及血糖浓度并与常规血糖检测指标进行比较。

Method : 198 inpatients with schizophrenia were divided randomly into chlorpromazine group and risperidone group . HbA1C and fasting plasma glucose were tested before treatment and at 1,2,3,6,12 month after treatment , and compared with clinical routine fasting plasma glucose test .