血友病甲

长距离PCR技术检测重型血友病甲Ⅷ因子基因倒位的进一步研究及推广应用

Further Study on Long Distance PCR Detection of Factor ⅷ Inversion Causing Severe Hemophilia A and Its Applications

凝血因子Ⅷ与中国人血友病甲研究进展

Advance in Study on Coagulation Factor ⅷ and Hemophilia A in China

FⅧ的结构与血友病甲

Structure of Factor ⅷ and Hemophilia A

应用长距离PCR技术对60例重型血友病甲进行Ⅷ因子基因倒位的基因诊断

Gene diagnosis of factor ⅷ gene inversion by LD-PCR for 60 patients with severe hemophilia A

1992～2000年血友病甲患者HCV、HBV、HIV和梅毒感染情况调查分析

Survey and Analysis on Positive Rate of HCV , HBsAg , HIV and Syphilis in Hemophilia A Patients During 1992-2000

血友病甲是一种常见的遗传性出血性疾病，由因子FⅧ缺乏引起。

Haemophilia A is the most common inherited bleeding disorder in human , which is caused by deficiency in factor ⅷ( F ⅷ) .

目的了解血友病甲患者乙型肝炎病毒（HBV）、艾滋病病毒（HIV）及梅毒的感染情况。

Objective To understand the infection with hepatitis B virus ( HBV ), Human immunodeficiency virus ( HIV ) and syphilis in patients with hemophilia A .

22例血友病甲家系采用BclⅠ，XbalⅠ多态位点和VNTR方法检测，检出率分别为55%，45%和36%。

22 haemophilia A families were assayed by polymorphism sites BcL I , Xbal I and VNTR , and positive rate was respectively 55 % , 45 % and 36.4 % .

脾移植治疗血友病甲10例的护理

Nursing Care of Splenic Transplantation in 10 Patients with Hemophilia A

血友病甲患者口腔出血原因调查及处理

Cause investigation and measures on oral hemorrhage of Hemophiliac A

结论亲属供脾脾脏移植是治疗血友病甲的有效方法，对于控制自发性出血和提高生活质量有重要的意义。

Conclusions Living-related-donor spleen transplantation is an effective method to treat hemophilia A.

现代生物技术的发展与血友病甲的治疗

Development of modern biotechnology and treatment of hemophilia A

尸体脾脏移植治疗血友病甲的临床观察

Clinical observation of the cadaveric spleen transplantation in the treatment of Hemophilia A

血友病甲四例家系调查

Survey on four case of hemophilia A family system

亲属供脾脾移植治疗血友病甲的围手术期处理

Experiences on perioperative treatment of living relative spleen transplantation

血友病甲患者Ⅷ因子检测及相关传染病调查

Quantitive Detection of Active Factor ⅷ and Investigation of Infectious Disease Relating with Hematophilia

目的：分析血友病甲患者口腔出血原因及处理措施。

Objective : To explore the causes of oral hemorrhage and measures of hemophiliac A.

目的探讨尸体脾移植治疗血友病甲的可行性。

Objective To investigate the feasibility of cadaveric spleen transplantation in the treatment of Hemophilia A.

胎脾移植治疗血友病甲五例报告

Fetal splenic transplantation for the treatment of Hemophilia A : a preliminary report of 5 cases

方法回顾性分析5例重症血友病甲行同种异体异位脾移植治疗手术后并发症的诊断及治疗。

Methods Five cases of spleen transplantation performed to treat severe hemophilia A were analyzed retrospectively .

因此，有待发现更多有效的遗传多态性标记用于血友病甲的连锁分析。

Thus , More effective DNA markers are needed to be found for linkage analysis of hemophilia A.

目的评价脾移植治疗血友病甲的效果和影响移植脾功能的因素。

Objective To evaluate the effect of spleen transplantation for Hemophilia A and factors involved in spleen function .

推广应用人凝血因子Ⅷ浓制剂对提高血友病甲的疗效将具有重要意义。

Therefore , its wider use in the treatment of hemophilia A and other factor ⅷ deficiency disorders would be of great significance .

研究结果提示术后近期均显一定效果.若能解决排斥等问题，此法可望成为治疗血友病甲的有效方法。

Our results suggested that if problem of rejection could be resolved , the fetal splenic transplantation would be an effective treatment for hemophilia A .

方法分析我院施行的5例亲属供脾脾移植术治疗血友病甲的围手术期循环系统、凝血系统及脾功监测和排斥反应，以及并发症的处理经验。

Methods The experiences of surveillance of circulation system , coagulation system , the function and rejection of transplanted spleen on 5 patients were analyzed .

现代生物技术的发展，尤其是蛋白质纯化技术及基因分子生物学技术的发展大大地推动了血友病甲的预防、诊断和治疗。

The development of modern biotechnology , especially of protein purification and gene molecular biology technology , has greatly prompted the prevention , diagnosis and treatment of hemophilia A.

方法为1例患血友病甲的男性患儿施行了尸体脾移植手术，术后观察患者凝血功能、病情恢复、移植脾脏状况及免疫抑制剂浓度监测。

Methods A cadaver spleen transplantation was performed on a 13 year male patient who suffered from hemophilia A. The blood coagulation function , illness recovery , the condition of the transplant spleen and FK506 blood concentration were monitored postoperatively .

为探讨胎脾移植治疗血友病的效果，对5例血友病甲患者施行了胳膊移植术。

The therapeutic efficacy of fetal splenic transplantation for the treatment of hemophilia A was investigated .