自杀基因

CD自杀基因联合淋巴细胞趋化因子基因疗法的肿瘤治疗作用及免疫机理研究

Combined Use of CD Suicide Gene and Lymphotactin Gene Therapy Elicit Potent Antitumor Effects

结论顺铂联合CD自杀基因能更有效地杀伤直肠腺癌细胞，可成为治疗直肠癌术后复发及转移的一种有效的方法。

Conclusion Cisplatin combined with CD suicide gene therapy may be used as a promising method for treating rectal neoplasm .

βG基因及βG前体药自杀基因系统对人膀胱癌细胞作用的实验研究

Experimental study on the efficacy of β G gene and β G prodrug system in the human bladder cancer cell

双自杀基因CD和TK对K562细胞体内外杀伤作用的实验研究

Killing effect of double suicide genes mediated by lentivirus on K562 cells

超声辐照载Fcy：：Fur自杀基因微泡治疗卵巢癌移植瘤的实验研究

Treatment of transplanted ovarian cancer by ultrasound-mediated Fcy : : Fur-loading microbubble destruction

自杀基因治疗鼠C6脑胶质瘤模型的动态MRI研究

The Therapeutic Effect of Suicide Gene on Rat C6 Glioma Model Dynamic Observation with HR MRI

硝基还原酶/CB1954自杀基因系统对宫颈癌Hela细胞杀伤效应的实验研究

The killing effects of nitroreductase / CB1954 suicide gene system on Hela cells

目的观察自杀基因CD联合GMCSF基因的抗胰腺癌作用。

Objective : To study the killing effect of suicide gene CD combined with GM-CSF gene to murine pancreatic cancer .

目的探索放射治疗联合自杀基因CD治疗小鼠胃癌，以加强自杀基因的抗肿瘤疗效。方法分别以自杀基因CD/5-Fc、β在射线及二者联合治疗小鼠胃癌模型，比较治疗效果。

Objective This study is aimed to combine radiotherapy with CD gene therapy on murine gastric cancer and to enhance suicide gene therapy .

RT-PCR检测双自杀基因和Cx43基因的表达。

The expression of CD 、 HSV-tk and Cx43 gene were detected by RT-PCR .

结果RT-PCR检测分析融合基因的表达，显示逆转录病毒介导的双自杀基因在C6胶质瘤细胞中表达。

Results RT-PCR analysis demonstrated the fusion gene could be effectively expressed in C6 glioma cells .

双自杀基因联合Survivin反义寡核苷酸对结肠癌裸鼠的体内抑瘤作用

Antitumor effect of double suicidal gene and survivin ASODN on colon cancer in nude mice in vivo

自杀基因CD、TK的共表达对人肺腺癌细胞的杀伤作用

Killing Effect of Human Pulmonary Adenocarcinoma Cells with TK + CD / 5-Fc + GCV Coexpression Suicide Gene Systems

可调控自杀基因的SCID小鼠乳腺癌基因治疗的研究

Treatment of Breast Cancer in SCID Mice with Regulatory Suicide Gene

目的构建含有CEA启动子（CEApromoter，Cp）启动的双自杀基因CD与TK的复制缺陷型腺病毒。

Objective To construct replication deficient adenovirus containing CD and TK gene promoted by CEA promoter ( Cp ) .

自杀基因（如HSV鄄TK基因）与免疫增强基因的联合应用；

Co-expression of suicide gene ( such as HSV-TK gene ) and gene enhancing immune response ;

目的探讨TK与CD双自杀基因对肝癌细胞的杀伤作用及旁观者效应，并在前药用量、杀伤效力及旁观者效应强弱等方面，与单自杀基因比较。

Objective To explore the cell killing and bystander effects of double suicide gene on hepatic cancer cells ( HCC ) .

目的：构建新型PNP/MepdR自杀基因系统的融合和单基因表达载体。

OBJECTIVE : To construct a fusion gene and a single gene expression vectors based on a novel PNP / Mep-dR suicide gene system .

目的：探讨双自杀基因CD和TK对K562细胞的体内外抑制作用及前体药物对肿瘤的杀伤作用。

OBJECTIVE : To study the killing effect of double suicide genes system on K562 cells in vivo and in vitro .

B7基因联合导入对自杀基因靶向化疗作用影响的电镜观察

Influence of combined transduction of B7 gene on suicide gene targeted chemotherapy

结论腺病毒介导的双自杀基因HSV鄄tk/CD在体外和体内均可产生旁观者效应。

Conclusion Adenovirus guided HSV-tk / CD fusion gene system can produce bystander effect in vivo and vitro .

腺病毒介导HSV-tk自杀基因联合野生型p53基因对直肠癌细胞的杀伤作用

Antitumor Effects of Adenovirus Mediated Coinfection of HSV tk Suicide Gene and Wild type p53 Gene on Rectal Cancer Cells

HSV-tk/GCV自杀基因治疗系统主要通过S期细胞周期阻滞对Hep-2细胞发挥体外抑制作用，没有明显的细胞凋亡和坏死。

HSV-tk gene transfected cells demonstrated obvious s-phase arrest , no apoptosis and necrosis occurred .

不同前药联合HSV-tk自杀基因系统对喉癌细胞体外杀伤效应的比较研究

Killing Effects of Different Prodrugs Combined With Suicide Gene HSV-tk on Hep-2 in Vitro

选择性复制型腺病毒介导的自杀基因HSV-tk在肿瘤基因治疗中的应用

The application of conditionally replication adenovirus-mediated suicide gene HSV-tk in the tumor gene therapy

但至今OA的治疗效果和方便程度无法令人满意，自杀基因治疗为骨关节炎的治疗提供了一种新的方法。

By so far the treatment of OA performs unconveniently , suicide gene therapy for the treatment of osteoarthritis is a new approach .

HIF依赖性表达的自杀基因抑制肾细胞癌生长的实验研究

HIF-dependent suicidal gene therapy system suppresses growth of renal cell carcinomas

pIRES介导的CD、TK双自杀基因构建及其对腺样囊性癌细胞杀伤作用的实验研究

An Experimental Study on the Construction of pIRES-CD 、 pIRES-TK and the Double Suicide Gene Therapy of Adenoid Cystic Carcinoma

双自杀基因对Raji淋巴瘤细胞杀伤的增强作用

Enhanced killing effect of double suicide genes transferred into Raji lymphoma cells by retroviral vector

由Egr-1基因启动子调控TK自杀基因治疗胰腺癌的实验研究

The Experimental Research on the Therapy of Pancreatic Cancer by TK Gene That Activated by Egr-1 Promoter