基因靶向

研究者通过基因靶向措施干扰猪细胞中正常的CFTR基因拷贝。

The researchers used gene targeting to disrupt one copy of the normal CFTR gene in pig cells .

并诞生了一门新技术――基因靶向。

It led to a new technology & gene targeting .

EGFR基因靶向RNA干扰抑制卵巢癌细胞增殖的研究

Inhibitory effects of targeting RNA of EGFR gene on the proliferation of human ovarian cancer cells

通过基因靶向疗法研究者们将产生ERα的基因传递入海马，维持小鼠的学习能力。

However , scientists were still able to rescue learning ability by delivering the correct gene to produce estrogen receptor-alpha directly to the hippocampus .

DCN将可能成为一种理想的肝癌基因靶向治疗药物。

DCN will become a new ideal target drug of gene therapy for HCC .

磁性阳离子脂质体介导CD-TK双自杀融合基因靶向治疗肝癌的实验研究

Experimental Study of Magnetic Cationic Liposomes-Mediated CD-TK Fusion Gene Targeted on Hepatoma

结论：载体介导的RNAi技术可成功地干扰TGF-β1在人胃癌细胞株SGC-7901和腹膜间皮细胞中的表达，为今后胃癌腹膜转移的基因靶向治疗奠定了基础。

CONCLUSION : TGF - β 1 expression can be notably inh - ibited in human gastric cancer cell line SGC-7901 and peritoneal mesothelial cells using plasmid-based TGF - β 1-RNAi technique .

探讨Wnt/β-catenin在EC增殖和分化中的作用和作用机制，不仅有助于阐明畸胎癌形成的分子调控机制，而且能为畸胎癌及相关生殖细胞肿瘤的基因靶向治疗提供有效的实验依据。

To study the effect and mechanism of Wnt / β - catenin signaling pathway in proliferation and differentiation of EC , could explain the molecular mechanism of the formation of teratocarcinoma , provide effective experimental evidence to genetic diagnosis and therapy in teratocarcinoma and germ cell tumors .

静脉注射用治疗基因靶向传递系统的研究

Study on the Targetable and Intravenous-injectable Vectors for Efficient Gene Delivery

这也引出一项新的技术&基因靶向技术。

It led to a new technology , Gene Targeting .

融合基因靶向性治疗人原发性肝细胞癌的实验研究

Experimental Study on Targeting Therapy for Human Primary Hepatocellular Cancer by Fusion Gene

基因靶向抑制反义生存素对脑胶质瘤细胞增殖和凋亡的影响

Effect of Survivin targeting on cell proliferation and apoptosis in glioma cell line

基因靶向技术的进步，带来了人类改造生命的可能。

Gene targeting technology , has brought the possibility of human transformation of life .

但是他们各自所研究的细胞类型不能用来培育基因靶向动物。

But the kinds of cells they independently studied could not be used to create gene-targeted animals .

基因靶向光动力治疗肿瘤

Gene-targeted photodynamic therapy on tumors

肿瘤的基因靶向治疗是通过将具有组织特异性的启动子序列与治疗基因偶联使治疗基因在肿瘤细胞中特异性表达，从而可以减轻对正常组织的损伤。

Therapeutic gene expression in tumor cells driven by tissue specific promoter can decrease damage to normal tissue .

个中原因，是基因靶向治疗提高了化疗的敏感性，还是两者之间具有协同作用，很少有实验研究加以考证和探讨。

Gene targeting improved the sensitivity of chemotherapy treatment or they are synergistic ? There were few experiments to research and explore .

“我们通过基因靶向技术在猪体内诱导出多能干细胞而去除这种受体”肖解释道。

" We could knock out this receptor in the pig via gene targeting in the pig induced pluripotent stem cell ," explained Xiao .

单一的基因靶向药物如格列卫将对大多数实体肿瘤有效是绝对不可能的。

It is extremely unlikely that drugs which target a single gene like Gleevec will be active against a major fraction of solid tumors .

为T细胞白血病的基因靶向治疗开辟了一条新途径，具有重要理论意义及临床应用前景。

The research opens up a new way for gene targeting treatment of T cell leukemia that has important theoretical significance and clinical application prospects .

今年夏天在一名接受基因靶向治疗36岁的关节炎病人死亡后暂停了发展中的基因治疗研究，美国食品药品管理局批准该研究的公司继续研究。

The FDA has given the go-ahead for a gene therapy study that was paused after a36-year-old arthritis patient died this summer , according to Targeted Genetics , the company that ran the study .

王的观点也受到奥利弗•史密斯的赞同，一个英国出生的美国遗传学家，2007年与一个美国人和一个英国人因对老鼠基因靶向技术的发展研究而共同获得诺贝尔生理学或医学奖。

Wang 's opinion is shared by Oliver Smithies , a British-born American geneticist who shared the 2007 Nobel Prize in Physiology or Medicine with an American and Briton for development of gene targeting in mice .

上述结果为乳腺癌患者进行早期预防、早期诊断、早期合理恰当的基因靶向治疗及准确判断预后提供了科学依据，因此具有良好的临床病理应用价值。

Results provide scientific basis for early prevention , early diagnosis , reasonable and appropriate treatment by gene targeting and accurate judgement prognosis in breast cancer , So , it has good clinical and pathological value .

基因组编辑是建立在基因靶向修饰的基础上，对生物基因组进行改造的一项新技术，通过在基因组水平上进行精确的基因编辑，实现基因的敲除、敲入、结构变异。

Genome Editing is a a new technology to transform biological genome based on gene targeting modified , through Precise gene editing in the genomic level , we can achieve the purpose of gene knockout and knockin structural variation .

目的探讨超声介导载血管内皮生长因子165（VEGF165）基因靶向微泡促梗死心肌血管新生的可行性。

Objective To explore the feasibility of directed delivering human vascular endothelial growth factor ( VEGF_ 165 ) to induce therapeutic angiogenesis in rat ′ s infracted myocardium zone with ultrasound mediated microbubbles ′ destruction which bear angiogenic growth factor gene .

载体介导的人支气管上皮细胞DNA聚合酶β基因的靶向RNA干扰

Vector-mediated RNA interference of DNA polymerase beta in human bronchial epithelial cells

PEG修饰对PLL-EGF基因载体靶向结合作用的影响

The Influence of PEG Modification on EGF-PLL Binding Capacities to EGFR

同源异型盒基因A5靶向RNA干扰对食管鳞癌增殖、凋亡的影响

Effect of RNA Interference Targeting Homeobox Gene A5 on Cell Proliferation and Apoptosis of Esophageal Squamous Cell Carcinoma

腺病毒介导HSV-TK基因血管靶向治疗裸鼠皮下人肝癌细胞移植瘤

Recombinant adenovirus mediated HSV-TK gene in vessel-targeted treatment of subcutaneously implanted HHC in mice

实验结果表明，通过CEA启动子控制bak基因能靶向性诱发CEA阳性肿瘤细胞凋亡。

The result showed that the CEA promoter could drive bak gene to induce apoptosis in CEA positive cells selectively .