自身抗原

卵白蛋白组：非自身抗原卵白蛋白加不完全福氏佐剂，卵白蛋白用量200μg/只。

Ovalbumin group : Each rat was treated with autoantigen ovalbumin ( 200 μ g ) plus incomplete Freund adjuvant ;

M2自身抗原及其三联体的克隆表达和初步鉴定

Cloning , expression and identification of M2 autoantigen and its trimer

B细胞活化辅助受体在对自身抗原的阴性选择中也起作用。

B cell activated co-receptor also has an effect on the negative selection of B cells reactive to autoantigens .

其特征是外周循环中可检出大量的针对自身抗原成分的自身抗体和抗原特异性T、B淋巴细胞。

Its characteristic is that lots of autoantibodies against autoantigens and variety of antigen-specific T / B lymphocytes can be detected in the peripheral circulation .

与Graves眼病有关的眼肌自身抗原抗体的分子免疫学研究

Molecular Immunological Studied of Eye Muscle Autoantigens and Antibodies Related to Graves ' Ophthalmopathy

ITP患者血小板活化依赖性自身抗原的研究

Study on Platelet Activation-Dependent Autoantigens in Patients with Idiopathic Thrombocytopenic Purpura

目前认为RA的发生是由抗原提呈细胞（APC）对自身抗原的异常提呈所引起的。

It is believed that RA is caused by the presentation of self antigen by APC .

目的对银屑病自身抗原&角蛋白17的HLADR限制性T细胞表位区进行确定。

Objective To identify the HLA-DR-restricted T cell epitope regions on keratin 17 ( K17 ), one of the autoantigens of psoriasis .

在STZ破坏胰岛细胞，自身抗原存在的同时，导致了自身免疫糖尿病的发生。

STZ destroys insulin and existence of self-antigen , meanwhile , results in the occurrence of autoimmune diabetes mellitus .

结论MBP是诱导MS发病的主要自身抗原之一，MBP可能主要在中枢神经系统中刺激IL16的产生；

Conclusion MBP is one of the autoantigens that induce MS , IL 16 may be mainly produced in CNS due to MBP stimulation ;

MHC分子给CD4+T细胞提呈自身抗原是T细胞活化的第一步。

These molecules present antigens to the T cell receptor of CD4 positive T cells as a first step in T cell activation .

小剂量口服自身抗原诱导免疫耐受可有效地抑制EAE和MS，这已被诸多研究所证实，但其机制尚不清楚。

Oral tolerance by feeding autoantigens is an effective method to prevent EAE and to treat MS , which mechanism has not been made very clear .

目的：探讨负载自身抗原的未成熟树突状细胞在体内外诱导免疫耐受的作用，为探索新的主动免疫方法防治SLE提供依据。

Objective : To investigate immature dendritic cells loading autoantigen induced immune tolerance , to explore new methods of active immunization to prevent and treat SLE .

其中，某些基因表达的异常可能诱发机体免疫监测系统对自身抗原的异常应答，因而可能参与了MG发病的始动过程。

Some of the different gene expressions may induce abnormal reactions of the immune system to antigens expressed on the surface of normal cells , which may play a important role in the onset of MG .

目的：研究自身抗原-谷氨酸脱羧酶（GAD）预防非肥胖糖尿病（NOD）雌鼠胰岛炎的作用及胰岛炎与NK细胞浸润的相互关系。

Objective : To study the effects of preventing insulitis by GAD and the relationships between the insulitis and the NK cells in NOD female mice .

目的探讨葡萄糖、肿瘤坏死因子（TNF）-α、干扰素（IFN）-γ对胰岛细胞自身抗原胰岛素瘤相关蛋白（IA）-2表达水平及胰岛素分泌水平的影响。

Objective To explore the effect of glucose and cytokine ( TNF - α, IFN - γ) to the level of insulinoma associated protein-2 ( IA-2 ) mRNA and insulin concentration .

结论凋亡细胞具有免疫原性，它可能是狼疮性BXSB小鼠体内自身抗原的主要来源；

Conclusion Apoptotic cells have immunogenicity , and may be the major source of autoantigens in lupus BXSB mice .

由于SLE患者体内广泛存在过度活化和凋亡的淋巴细胞，因此由它们释放大量的DNA等自身抗原，从而可能诱导了耐受的打破和自身抗体的产生。

Since the extensive lymphocytes activation and excessive apoptosis could be observed in the SLE patients , the large amount of released DNA may comprise the major source of such kind of autoantigen to induced the production of autoantibodies .

自身抗原核点蛋白Sp100基因克隆和真核表达

Gene cloning and fusion expression of human autoantigen Sp100 in yeasts

结论：RA滑膜中DC和被激活的DC及HLA-DR阳性细胞的存在和增多可能在RA病变局部提呈自身抗原的过程中起重要的作用，是RA自身免疫异常的重要的始发因素。

CONCLUSION : Larger quantity and more activated DCs and HLA DR + cells may play an important role in antigen presentation existed in the synovium of RA , which are important in initiating autoimmune reaction and development of RA .

目的探讨自身抗原诱导免疫耐受防治1型糖尿病（IDDM）的方法及机制。

Objective To probe into the method and mechanism of the prevention and treatment of IDDM in mice by induction of immune tolerance with the autoantigen insulin .

检测重组腺病毒的转染效率、转基因DC对抗脂多糖（LPS）促成熟的能力、介导同种异体T细胞增殖能力、抗原递呈功能的改变、吞噬功能分析及表面表达自身抗原的情况。

The transduction efficiency , the capability of transgenic DC to counter lipopolysaccharide ( LPS ), to induce allogenic T cells proliferation , to present antigen , and to intake antigen were detected and autoantigen epitope expression in transgenic DC surface was analyzed .

自身抗原OGDC-E2融合蛋白的克隆表达与鉴定

The cDNA cloning and expression of autoantigen OGDC-E2

目前认为是髓鞘糖蛋白（MOG）作为自身抗原被自身反应性T细胞识别，这些自身反应的T细胞通过血脑屏障迁移到中枢系统，诱导炎症的发生。

It is demonstrated recently that auto reactive T cells identify myelin as special antigen , cross the blood-brain barrier and trigger the disease .

但Flk-1属自身抗原，研究人员面临如何才能增强其免疫原性，打破免疫耐受激发有效免疫应答的难题。

But Flk-1 is self-antigen . A major challenge is to break the immune tolerance and induce a robust , long-lived T cell-mediated immunity which leads to an effective suppression of tumor angiogenesis .

方法：用原位切口标记法和免疫荧光法测定了19例光敏感型红斑狼疮（LE）患者新鲜皮损内自身抗原SSA/Ro表达情况和角质形成细胞凋亡情况。

Methods : 19 skin lesions from photosensitive form of LE patients were studied with the nike labeling of apoptotic DNA mid immunofluorescence . Results : It was showed that SSA / Ro expression and apoptotic KC were found in 7 fresh skin lesions in sim in LE patient .

结论本研究成功克隆人核包膜蛋白自身抗原gp210、p62和LBR基因，并将其在大肠杆菌中成功表达。

Conclusion The human plasmid containing gp210 、 p62 、 LBR is successfully cloned into E coli BL21 、 M15 . The results of ELISA show its good antigenicity and specificity .

人癌症中的自身抗原是免疫系统识别的最普遍抗原，说明癌细胞源于宿主自身组织而非外源蛋白。

Self-antigens are the most common anti-gens that are recognized in human cancer .

角质形成细胞对MHC-Ⅰ限制的自身抗原呈递作用的体外研究

Presentation of an Endogenous MHC Class ⅰ Restricted Autoantigen by Keratinocytes in Vitro

自身抗原组氨酰转移核糖核酸合成酶基因在巴斯德毕赤酵母中的分泌表达研究

Secreted Expression of Recombinant Human Autoantigen Histidyl-tRNA Synthetase in Methylotrophic Yeast Pichia pastoris