免疫耐受

成熟DC可以激活静息T细胞而介导移植排斥；不成熟DC由于共刺激分子表达缺陷，而诱导T细胞的无反应性，导致免疫耐受。

The mature DC can activate naive T cells to intermediate transplantation rejection . Immature DC can induce T cells non-responsiveness to cause the immunological tolerance because of the costimulator molecule expressive defects .

美国免疫学教授Forrest基于SNS模型提出了否定选择算法，成功的模拟了免疫耐受的过程。

The American immunologist Forrest provoked the negative selection algorithm based on the SNS model and successfully simulated the procedure of immunological tolerance .

受体选择与B细胞自身免疫耐受

Receptor Selection and B Cell Immune Tolerance

近年更多的研究表明，DC在外周免疫耐受中起关键性作用。

Recently investigations indicated that DCs play a critical role in the peripheral tolerance .

但NF-κB在口服免疫耐受中的活性改变，尚无文献报道。

Nevertheless , the change of activity of NF - κ B in oral tolerance is not still documented .

目的研究HBV转基因小鼠免疫耐受状态机制。

To study immune tolerance mechanism of HBV transgenic mice ( HBV-Tg ) .

HLA衍生肽诱导移植免疫耐受机制的研究概况

Survey of mechanism of transplantation tolerance induced by HLA derived peptides

Th1/Th2细胞因子mRNA的表达与心脏移植免疫耐受的关系

The relationship between Th1 / Th2 cytokines mRNA expression and immune tolerance to cardiac allografts in rats

可溶性TNF受体基因修饰的树突状细胞诱导抗原特异性肿瘤免疫耐受的机理

Soluble TNF - α Receptor Gene Modified Dendritic Cells Induce Antigen Specific Tolerance to Tumor-Isograft

独特型网络AB模型免疫耐受的研究

A modeling study of acquired immune tolerance due to idiotypic network

HBsAg蛋白疫苗对HBV感染免疫耐受患者的治疗作用

Therapeutic effects of HBsAg protein vaccine on hepatitis B viral carriers with immune tolerance

目的研究未成熟树突状细胞（DC）在协调性异种胰岛移植中的免疫耐受诱导作用。

Objective To investigate the inducible effect of immature dendritic cells ( DC ) on immune tolerance in coordination islet xenotransplantation .

结论：慢性HBV感染免疫耐受与DC的缺陷有关。

Conclusion : The pathogenesis of immunotolerance in chronic persistent HBV infection is associated with the defect of DCs .

外源性IL-2能逆转免疫耐受。

The immune tolerance can be reversed by IL-2 .

而HBV感染导致T细胞免疫耐受的确切机制还不清楚。

The mechanisms responsible for the T cell tolerance in chronic HBV infection are not completely understood .

通过过继转移免疫耐受性DC，可明显降低糖尿病高血糖以及小鼠脾淋巴细胞增殖能力，与模型对照组差异有统计学意义（P＜0.01）；

Both of the high level blood glucose and T cell proliferation were decreased significantly by adoptive transfer of tolerogenic DC ( P < 0.01 );

转Fas配体基因的树突状细胞在诱导大鼠肝移植免疫耐受中的作用

Mechanism of tolerance inducement in rat liver transplantation by constructing retroviral vector containing FasL gene

MHCⅠ类基因转移诱导移植免疫耐受的研究

Induction of Allograft Tolerance by Transfer of MHC Class I Genes

结果提示口服CⅡ诱导免疫耐受、治疗类风湿性关节炎可能与CⅡ特性和胰蛋白酶对其的作用有关。

The results suggest that the inducing immunotolerance to treat RA by oral administration of C ⅱ is possibly concerned with the C ⅱ characteristics and trypsin enzymolysis .

供者NK细胞诱导小鼠MHC半相合骨髓移植的免疫耐受

Immune tolerance induced by donor-derived NK cells of MHC haplotype-mismatched BMT in mice

抗CD4单抗诱导免疫耐受防治自身免疫性心肌炎的研究

Monoclonal anti-CD4 prevents the development of experimental autoimmune myocarditis by inducing immune tolerance to cardiac myosin

B~（16）黑色素瘤NK免疫耐受变异群在体外的产生及其意义

A new nk-tolerant variant subset of B16 melanoma cells produced in vitro and its significance

IL-2在免疫耐受中的作用

Role of IL-2 in immune tolerance

结论：高浓度的IL-10和雷公藤多甙联合应用诱导的未成熟DC具有诱导免疫耐受的应用价值。

Conclusion : immature DC induced by high concentration of IL-10 combined with Tw may be applied in inducing immune tolerance .

OVA免疫耐受因子制备及其免疫活性研究

The Research on Preparation and Immunoactivity of OVA Immune Tolerance Factor

抗CD4、CD8单抗诱导异基因骨髓移植嵌合供体小鼠免疫耐受

Induction of chimerism donor mouse immune tolerance to allogeneic bone marrow transplantation by anti-CD4 and CD8 monoclonal antibody

基因工程化抗CD3单克隆抗体及其诱导免疫耐受的研究进展

Progresses in the engineered CD3 antibodies and the immunologic tolerance induced by anti-CD3 mAbs

NOD鼠口服胰岛素诱导免疫耐受的疗效及形态学观察

The effect and morphology observation of oral administration insulin to NOD mice inducing immune tolerance

睾丸Sertoli细胞诱导大鼠肝移植免疫耐受的实验研究

Testicle Sertoli Cells Induce Rat Liver Transplantation Immunologic Tolerance : Experimental Research

目的探讨霉酚酸酯（MMF）处理的供者来源的树突状细胞（DC）在诱导免疫耐受中的作用。

Objective To explore the effects of donor dendritic cells treated with MMF in tolerance induction in allograft recipients .