神经酰胺

它们是神经酰胺，PCA和尿素等。

Those factors include ceramide , PCA , lactic acid and urea et al .

方法分离猪血细胞，用溶血，脱水，干燥等方法提取鞘磷脂，并用磷脂酶C降解鞘磷脂成神经酰胺。

METHOD Sphingomyelin was prepared through the process of separating erythrocyte from blood , erythrocytolysis , dehydration , dry , et al , and then hydrolyzed to ceramide by phospholipase C.

丝裂霉素C联合C2-神经酰胺对人膀胱癌T（24）细胞生长的抑制作用

Inhibition effect of combining mitomycin C with C_2-ceramide on human bladder cancer T_24 cells

C2-神经酰胺诱导肝癌细胞凋亡

Apoptosis of Hepatoma Cells Induced by C_2-Ceramide

丝裂霉素C与C2-神经酰胺联合应用治疗膀胱癌

Experimental study on the therapeutic effectiveness of combined use of mitomycin C with C_2-ceramide on human bladder cancer cells

丝裂霉素C与C2-神经酰胺或抗Fas单克隆抗体联合治疗膀胱癌的体外研究

Effect of mitomycin C combined with C_2-ceramide or anti-Fas monoclonal antibody in human bladder cancer cells

早期的研究成果发表在Blood上，研究人员发现神经酰胺脂质体在患有大颗粒淋巴细胞白血病的鼠中可以诱导侵袭性的完全缓解。

In an earlier study published in the journal Blood , researchers observed that cerasome use led to complete remission in aggressive , large granular lymphocytic leukemia in rats .

线粒体神经酰胺酶转染K562细胞，通过其下游代谢产物1-磷酸鞘氨醇，上调抗凋亡蛋白Bcl-2表达水平

Mitochondrial Ceramidase Overexpression Up-regulates Bcl-2 Protein Level in K562 Cells , Probably Through Its Metabolic Product Sphingosine-1-phosphate

地昔帕明对胶质瘤C6细胞增殖抑制的神经酰胺通路

Desipramine inhibited proliferation of glioma C6 cell via ceramide pathway

C2-神经酰胺诱导大鼠脑胶质瘤细胞C6的早期凋亡作用

Induction effects of C2-ceramide on early apoptosis in rat glioma cell C6

神经酰胺通过非p53途径诱导鼻咽癌细胞中p21~（WAF1）的表达

Ceramide Induces p21 ~ ( WAF1 ) Expression Through p53-independent Pathway in Nasopharyngeal Carcinoma Cells

脑组织中神经酰胺、白细胞介素-1β、caspase-3在脑创伤后的改变和作用

Study on changes of ceramide , interleukin-1 β and caspase-3 in cerebrum after traumatic brain injury

半乳糖神经酰胺脂质体对HIV-1感染性的影响

Effects of galactosylceramide liposomes on HIV-1 infectivity

结论神经酰胺可增加LDH漏出率，但对细胞总LDH代谢无影响。

Conclusion Ceramide elevates the leakage rate of LDH and has no effect on total LDH metabolism of neurons .

神经酰胺和凋亡诱导因子在UVA诱导细胞凋亡中的作用

Roles of Ceramide and Apoptosis - inducing Factor in UVA-induced Apoptosis

神经酰胺作为细胞凋亡的第二信使，参与多种细胞凋亡，它与凋亡相关因子bcl-2、NF-κB的关系一直是研究的重点。

Ceramide functions as a second messenger to several signaling pathways , and the relationship between it and bcl-2 or NF - κ B has always been emphasized .

MTT法检测C2-神经酰胺对HT-29细胞线粒体功能的影响。

MTT test was used to detect the mitochondrial function of HT-29 cells resulted by C_2-ceramide .

目的观察丝裂霉素C（MMC）与C2-神经酰胺（C2-cer）联合应用对人膀胱癌细胞的作用效果，并探讨其机制。

Objective To evaluate the therapeutic effectiveness of combined use of mitomycin C ( MMC ) with C_2-ceramide ( C_2-cer ) on human bladder cancer cells and the mechanism .

结论：γ射线可诱导内皮细胞凋亡，并可被G-CSF抑制，其作用可能与细胞内神经酰胺和蛋白激酶C平衡的改变有关。

Conclusions : Radiation-induced apoptosis of Ecs may be inhibited by G-CSF and related to the variation of balance between ceramide and PKC signal systems .

目的研究神经酰胺对小鼠皮层神经元乳酸脱氢酶（LDH）代谢的影响。

Objective To explore whether natural ceramide has effect on lactate dehydrogenase ( LDH ) metabolism in primary cultured mice cortical neurons .

方法：1、MTT法检测三种葡萄糖苷神经酰胺合酶抑制剂对人神经胶质瘤细胞增殖的影响。

Method : 1 、 The effect of three different inhibitors of glycosphingolipid biosynthesis on SHG cells growth was measured by MTT assay .

UVA诱导的细胞凋亡通过神经酰胺和JNK信号通路

UVA-induced apoptosis via ceramide and JNK signaling pathway

结论外源性神经酰胺能诱导人结肠癌HT-29细胞凋亡，参与其凋亡调控。

Conclusion Exogenous ceramide induces apoptosis of HT-29 cells and participates in regulation of apoptosis in vitro .

我们的结果显示神经酰胺、p38和ERK1/ERK2在细胞增殖和刺激诱导的细胞凋亡中起着关键但截然不同的作用。

Our results indicate that ceramide , p38 , and ERK1 / ERK2 play critical but differential roles in cell proliferation and stress-induced apoptosis .

“神经酰胺脂质体的优势在于它对正常的细胞是无毒作用的，使他们处于睡眠中，然而可以选择性的杀死肿瘤细胞，”MarkKester，Ph。

" The beauty of ceramide is that it is non-toxic to normal cells , putting them to sleep , while selectively killing cancer cells ," said Mark Kester , Ph.

近年来，葡萄糖神经酰胺合成酶（glucosylceramidesynthase，GCS）介导的凋亡调控与MDR方面的研究引起了人们的关注。

In recent years , researchers put more attention to the relationship between apoptosis induced by Glucosylceramide synthase ( GCS ) and MDR .

小鼠腹腔注射MCLR毒素后，肾脏可检测神经酰胺的生成，并可检测到升高的细胞凋亡。

Ceramide generation and increased apoptosis can be found in mouse kidney after MCLR injection .

Summers说，尽管其他接下来的研究发现输入不饱和脂肪的动物也出现胰岛素抵抗，但并没有发现神经酰胺含量增高。

However , others subsequently examined animals infused with unsaturated oils and found that they became insulin resistant without any rise in ceramide , Summers said .

“神经酰胺脂质体可以作为普通化疗选择的一种治疗剂，”Kester说。

" Cerasomes were designed as a therapeutic alternative to common chemotherapeutics ," said Kester .

目的研究脑组织中白细胞介素-1β（IL-1β）、神经酰胺、caspase-3在创伤性脑损伤（TBI）后的改变和相互作用。

Objective To study the changes and effects of ceramide , interleukin 1 β( IL 1 β) and caspase 3 in cerebrum after traumatic brain injury ( TBI ) .