糖基

改造糖基侧链合成新型抗生素的研究进展

Advances in synthesis of new antibiotics by modifying glycosyl chains

合成的氨基酸、糖基修饰的环糊精衍生物可作为靶向药物载体。

The synthetic amino acid and glycosyl modified CDs can be used as targetable drug carriers .

细菌在糖基中生长。

The bacteria were growing in a sugar medium .

目的鉴定γB－晶体蛋白非酶糖基化位点。

Objective To identify the glycation sites of lens γ B-crystallin .

能够抑制糖基化终末产物（AGE）的产生，以减少其毒性作用；

Restrain advanced glycation end products ( AGE ) and alleviate toxicity ;

肝靶向半乳糖基细胞色素C的合成及其肝靶向性研究

Preparation of Galactosyl Cytochrome C and Studies on Its Hepatic Targeting Property

晚期糖基化终末产物和蛋白激酶C对糖尿病大鼠肾脏的影响

Relationship among advanced glycosylation end products , protein kinase C and renal

可改变DNA构象的非离子糖基表面活性剂

Sugar-based Nonionic Surfactant that can Change the Conformation of DNA

N-烷基嘧啶DNA糖基化酶腺病毒提高人骨肉瘤化疗敏感性的研究

Effect of adenoviral N-methylpurine DNA glycosylase overexpression on chemosensitivity of human osteosarcoma cells

C反应蛋白增加人内皮细胞糖基化终产物受体表达

C Reactive Protein Increases the Expression of Receptor for Advanced Glycation End-products in Human Endothelial Cells

序列中有N一糖基化位点，蛋白激酶C磷酸化位点和酪蛋白激酶11磷酸化位点；

The sequence has N-glycosylation site , Protein kinase C phosphorylation site and Casein kinase II phosphorylation site .

目的建立小分子糖基化终产物肽（AGEP）的一种检测方法。

Objective To establish an analyzing approach for low molecular weight advanced glycosylation end products peptide ( AGE P ) .

N糖基化抑制对脑胶质瘤细胞株SWO-38N-GSLs合成的影响

Study on the Effects of N-glycosylation Inhibition on the Expression of N-GSLs in Glioma Cell Line SWO-38

它们都含有高百分比的脯氨酸（P）、丝氨酸（S）和苏氨酸（T），含有相当数量的位于胞外区的O-连接糖基化位点。

These predicted G proteins had a relatively high contents of proline , serine , threonine residues and O-linked glycosylation sites .

研究表明：AD脑神经丝蛋白的糖基化修饰水平降低，伴随着磷酸化修饰水平增加，其机制目前尚不清楚。

The study demonstrated that O-Glycosylation of neurofilaments decreased and phosphorylation increased in AD brains .

上述功能的发挥，很大程度上依赖于其胞外区片段（extracellulardomain，ed）的表达及糖基化修饰作用。

The exertion of the function mostly depend on the expression and glycosylation of its extracellular domain .

采用半定量RTPCR检测糖基转移酶的表达，将有助于对胆管癌的诊断和预后判断。

Semiquantitative RT-PCR determination of specific glycosyltransferases may be helpful for diagnosis and prognosis of BDC .

S蛋白由1256个氨基酸组成，有23个潜在的糖基化位点，其N端和C端相对保守。

SARS-CoV Spike protein , which has 23 pieces larvaceous glycosylation sit , consists of 1256 amino acid . Its N-terminals and C-terminals is corresponding conservative .

黄芪对IgA肾病患者免疫球蛋白分子糖基化异常的调节作用

The Effect of Astragalus Membranaceus on Galactosylation of IgA in IgA Nephropathy Patients

经PEG表面修饰的纳米粒仍保持纳米粒的体外转染活性。连接半乳糖基牛血清白蛋白的纳米粒转染活性却反而略有下降。

After the particles were modified with PEG , their transfection activity was still remained .

而最近研究发现，晚期糖基化终产物受体（receptorforadvancedglycationendproducts，RAGE）与前列腺癌也密切相关。

Recent studies have found that the receptor for advanced glycation end products ( RAGE ) is closely related to prostate cancer .

癌基因ras对β-1,4-半乳糖基转移酶活性的调节

The Regulation of Activity of β - 1 , 4-Galactosyltransferase by Oncogene ras

结论：糖基化终产物可促进大鼠主动脉平滑肌细胞MMP-2的表达。

Conclusion : Expression of MMP-2 of VSMCs can be promoted by AGEs .

雷公藤内酯醇对IgA肾病大鼠血清IgA异常糖基化的影响

Effects of triptolide on abnormal glycosylation of serum IgA in rats with IgA nephropathy

糖基化低密度脂蛋白增强人外周血单核巨噬细胞的Sis基因表达

Enhancement of sis Gene Expression in Human Monocyte-macrophages by Glycosylated Low Density Lipoprotein

SDS-PAGE结果和FT-IR分析结果均证明了糖基化接枝反应的发生。

The results of SDS-PAGE and infrared analysis proved that the glycosylation grafting reaction happened .

N，N-二（2-氯乙基）糖基磷酰氨基酸甲酯ESIMS裂解规律研究

Characteristic Fragmentation of N , N-bis ( 2 - chloroethyl ) - O-glycosyl-phosphoryl Amino Acid Methyl Esters in ESI MS

GSH、LA与蛋白糖基化反应体系共育后AGEs含量均显著下降，GSH强于LA的作用，但对体系内羰基含量无明显影响；

AGEs content was significantly decreased after protein glycation system were incubated with GSH and LA for 8 weeks .

PAI－1糖基化位点突变体的构建及其在哺乳动物细胞中表达

Construction of mutant glycosylation sites of PAI-1 and expression in mammalian cells

目的探讨N糖基化抑制对肿瘤细胞中性鞘糖脂（NGSLs）合成的影响。

To study the effects of N-glycosylation inhibition on the expression of neutral glycosphingolipids ( N-GSLs ) in cells .