鞘脂

Caveolae由胆固醇、鞘脂及蛋白质组成。

Caveolae consists of cholesterol , sphingolipid and proteins .

鞘脂（sphingolipids）除了作为真核生物中膜结构的重要组成成分外，它还能作为重要的信号分子调节细胞的增值、分化和死亡。

Sphingolipid is not only the important component of eukaryotic membranes , but also as an important signal molecule to regulate cell differentiation and death .

脂微区为近年发现的广泛存在于质膜，主要由糖鞘脂、鞘磷脂、胆固醇及多GPI锚联蛋白组成的局限性结构域。

Membrane lipid microdomain is a newly discovered membrane confined domain which consists of sphingomyelin , cholesterol , glycosphingolipid and many GPI anchored proteins .

结论：外源表达的鞘脂激活肽NP能够促进前列腺癌细胞的增殖，并能影响细胞周期各时相的变化。

Conclusion : Ectopic expression of NP could enhance the prostate cancer cell growth and affect the cell cycle .

非律平菌素干扰甲基硝基亚硝基胍对FL细胞鞘脂代谢的影响

Filipin Interferes with the Effects of N-Methyl-N ′ - nitro-N-nitrosoguanidine on Sphingolipids Metabolism in Human Amnion FL Cells

结果发现：GBS患者血清抗髓鞘脂抗体水平增高，与正常和疾病对照组相比有非常显著性差异（P＜0.01）。

The result showed that the serum anti-myelin sheath antibody increased in patients with GBS , compared with the other two groups , and the difference was significant .

在细胞表面，GPI锚定蛋白常与鞘脂（包括鞘糖脂和鞘磷脂），胆固醇等聚集在一起形成具有特定结构和功能的质膜微区，称GPI微域（GPImicrodomain）。

GPI-anchored proteins often gather with sphingolipids ( including sphingomyelin and glycosphingolipid ) and cholesterol to form special plasma membrane microdomains ( GPI microdomain ) .

应用ELISA方法对28例格林－巴利综合征（GBS）患者和30例正常对照者、30例疾病对照者进行血清抗髓鞘脂抗体检测，并对其中5例进行动态观察。

We used ELISA to determine the serum anti-myelin sheath antibody in 28 patients with Guillain-Barre syndrome 30 healthy subjects and 30 patients with other neurologic diseases . A dynamic observation was performed in 5 patients with GBS .

植物鞘脂的结构、代谢途径及其功能

Structure , Metabolic Pathway and Function of Sphingolipids in Plants

神经鞘脂病的酶学诊断方法&用培养的人皮肤成纤维细胞检测

The enzymic diagnosis of sphingolipidosis with cultured human skin fibroblast

鞘脂激活肽真核表达载体的构建及其对前列腺癌细胞增殖的影响

Effect of ectopic expressed Neurotrophic Peptide on proliferation of human prostate cancer cells

糖鞘脂Gb3的配体结构与配体胞内运输的关系

Correlation between the Ligand Structure and Their Intracellular Transport

但是目前对植物鞘脂的了解还十分有限。

However , the current understanding about the plant sphingolipid metabolism is very limited .

目的研究利用少动鞘脂单胞菌发酵生产胞外多糖结冷胶的摇瓶发酵条件。

Objective This paper researches the fermentation condition of gellan gum production utilizing Sphingomonas paucimobilis .

目的优化少动鞘脂单胞菌发酵生产结冷胶的工艺。

Objective To optimize the fermentation production process of gellan gum by utilizing Sphingomonas paucimobilis .

最近的研究发现，鞘脂及其代谢产物在植物中也起着很重要的信号分子作用。

Increasing investigation has shown that sphingolipids and their metabolites play an important role in plants .

鞘脂在植物中的研究最近几年才开始，植物鞘脂的功能还不十分清楚。

However , the biological function of sphingolipids in plants has been explored only recently and remains elusive .

神经鞘脂病是一类神经鞘脂分解代谢障碍的遗传性疾病，酶学检测是确诊的一种主要手段。

Sphingolipidosis is a group of hereditary diseases characterised by the deficiency in enzymes responsible for catabolism of sphingolipids .

神经酰胺通过神经酰胺酶水解生成脂肪酸和长链基团，它是以神经酰胺为中心的鞘脂代谢途径的重要组成部分。

Ceramidase hydrolyze ceramide into fatty acid and chain base , which is an important part in metabolic pathway of sphingolipids .

结果提示包括海参在内的海洋食品可以作为功能性鞘脂类的良好资源。

The results suggest that marine foods , including sea cucumbers , can be useful resources of the functional sphingolipids . 2 .

嗜热菌杀酵母素通过耗尽细胞的鞘脂类诱导凋亡，抑制白介素2依赖性的小鼠毒性细胞的增殖，是一种有效的免疫抑制剂。

Myriocin induces apoptosis by depletion of cellular sphingolipids , inhibits proliferation of IL-2-dependent mouse cytotoxic cells and is a potent immunosuppressant .

研究背景：鞘脂是真核细胞膜的主要成分，能代谢产生多种重要的信号分子。

Backgrounds : Sphingolipids are the essential components of plasma membrane of eukaryotic cells and their metabolites usually work as important biological signaling molecules .

鞘脂储存类疾病，如泰萨二氏病、脑苷脂沉积病和神经鞘磷脂沉积病，都涉及到连接神经细胞的凸起的多余生长和分叉。

The sphingolipid-storage diseases , Tay-Sachs , Gaucher 's and Niemann-Pick , all involve extra growth and branching of the protuberances that connect nerve cells together .

鞘氨醇单胞菌具有特殊的细胞结构，最显著的是细胞膜用鞘脂糖代替了脂多糖，这使其与传统意义上的革兰氏阴性菌具有显著区别。

The genus is characterized by an outer membrane that contains glycosphingolipids instead of lipopolysaccharide , which makes it different from the traditional Gram-negative aerobic bacter .

神经酰胺作为神经鞘脂类的主要成员之一，是一个主要调节细胞活动的第二信使，以转导细胞凋亡等细胞生长抑制活动信号为主。

Ceramide as an important member of sphingolipid is a second messenger responsible for regulating cellular activities , whose major function is to transmit growth-inhibiting signals including apoptotic .

结果表明，系统规律的有氧运动使与能量代谢，尤其是三羧酸循环相关酶基因表达上调，而使肌肉蛋白合成相关基因和神经鞘脂类相关基因表达下调。

Systemic and routine aerobic exercise could up-regulate genes concerning energy metabolism , especially enzymes in TCA cycle and down-regulate those related to protein synthesis in muscle and sphingolipid metabolism .

小窝是脂筏的一种类型，由胆固醇、鞘脂及蛋白质组成，以小窝蛋白为标记蛋白。

Caveolae , a type of lipid rafts , is characterized by high levels of cholesterol , sphingolipids and proteins , and is identified by the presence of the protein caveolin .

鞘脂及其衍生物在生物体内参与了极重要的细胞功能，它们可以作为第二信使调控细胞生长、分化、存活、增殖和程序性死亡等。

There is now substantial evidence that sphingolipids and their metabolic products are involved in the regulation of cell growth , differentiation , survival , proliferation and programmed cell death via their participation as second messengers in specific signal-transduction pathways .

近几年才开始对植物中的鞘脂进行研究，目前植物鞘脂的功能还不十分清楚，然而最近的研究发现鞘脂及其代谢产物在植物中也起着很重要的信号作用。

The research of sphingolipids in plants has been explored only in recent years , Far less is known about sphingolipids functions in plants . However , increasingly investigations indicate that sphingolipids and their derivants have important signalling roles in plants as well .