裂解疫苗

流感疫苗经过五十多年的发展，主要有灭活全病毒疫苗、裂解疫苗、亚单位疫苗、DNA疫苗和减毒活疫苗。

Though influenza vaccines have been produced for over 50 years , vaccination is still the principal method of prophylaxis . Vaccines can be characterized as whole virus vaccines , split virus vaccines , surface antigen vaccines , DNA vaccines and live attenuated vaccines .

流行性感冒灭活亚单位疫苗和裂解疫苗的安全性和免疫原性的比较研究

Comparative study on safety and immunogenicity between influenza subunit vaccine and split vaccine

国产与进口流行性感冒病毒裂解疫苗安全性和免疫原性的Meta分析

The Meta Analysis on the Safety and Immunogenicity of Domestic and Imported Split Influenza Virus Vaccines

流行性感冒病毒裂解疫苗安全性与免疫原性研究

Evaluation on the Safety and Immunogenicity of Split Influenza Virus Vaccine

目的进行流行性感冒病毒裂解疫苗的病毒灭活检测，研究病毒灭活状况。

Objective To test the viral inactivation of split influenza virus vaccine .

研制安全有效的流行性感冒病毒裂解疫苗。

Objective To prepare a safe and effective split influenza virus vaccine .

流感裂解疫苗生产中沙门菌和微生物限度的监控研究

Monitoring of Salmonella and microbial limits of influenza vaccine semiproduct

研制新型的流行性感冒病毒裂解疫苗，并评价其免疫效果。

To develop split influenza virus vaccine and evaluate its immunological effect .

流感病毒裂解疫苗及单价病毒液的血凝素稳定性研究

Stability study of hemagglutinin of split influenza virus vaccines and monovalent virus pools

人群接种流感裂解疫苗的安全性评价

Security evaluation for split influenza vaccination in human population

目的优化大规模生产的流感病毒裂解疫苗的纯化及裂解工艺。

Objective To optimize the procedure for purification and lysis of influenza virus vaccine .

目前市场应用的流感疫苗主要有三种：全病毒灭活疫苗、裂解疫苗、亚单位疫苗。

The inactivated vaccine , split vaccine and subunit vaccines are currently used in humans .

目的比较流感亚单位疫苗与裂解疫苗的安全性和免疫原性。

Objective To compare the reactogenicity and serology between influenza subunit vaccine and split vaccine .

已建立了切实可行的流感病毒裂解疫苗规模生产的纯化及裂解工艺。

A practical and feasible procedure for purification and lysis of influenza vaccine was developed .

目的评价国产流行性感冒裂解疫苗的临床反应和免疫原性。

Objective To evaluate the adverse reaction and immunogenicity of domestic lytic influenza virus vaccine in humans .

兰州生物制品研究所研制的流行性感冒病毒裂解疫苗于2003年9月~12月在广西进行Ⅰ~Ⅲ临床试验，对疫苗的安全性和免疫原性进行考核评价。

The clinical trials of the split influenza virus vaccine were undertaken in Guangxi province by Lanzhou Institute of Biological Products .

目的对上海生物制品研究所研制生产的流行性感冒病毒裂解疫苗进行临床安全性的研究；

Objective To observe the clinical safety of Split Influenza Virus Vaccine , which were produced by the Shanghai Institute of Biological Products .

方法采用薄膜蒸发与冷冻干燥相结合的方法制得多层脂质体，与流感裂解疫苗按比例混合，制备脂质体流感疫苗。

Methods Prepare multilaminar liposome by film evaporation combined with lyophilization , then mix with influenza split vaccine at a certain ratio and lyophilize .

三批流行性感冒病毒裂解疫苗经中国药品生物制品检定所检定合格，并通过临床考核，取得令人满意的免疫效果。

Three batches of split influenza virus vaccine had passed the tests given by the National Institute of Control of Pharmaceutical and Biological Products .

与马血清、羊血清、人血清白蛋白、牛血清白蛋白、流行性感冒病毒裂解疫苗基质液及其他无残留卵清蛋白的疫苗均无交叉反应。

No cross reactions were observed with horse serum , sheep serum , human serum albumin , bovine serum albumin , diluent for split influenza virus vaccine , and other vaccines without ovalbumin .

结论：本调查结果表明流感裂解疫苗的副反应发生率低且反应轻微，安全性较高，可用于人群的大规模预防接种及疫情应急接种。

Conclusion : According to the investigation , it is concluded that the split influenza vaccine is safety with a low frequency and light manifestation of adverse effects , and it can be used in vaccination for wide population and emergency .

目前，我国多用裂解流感疫苗。

At present , the use of influenza vaccine cleavage .

结论裂解-2疫苗优于其他2种；

Conclusion The production technique of split-2 vaccine was better than the other two .

流感裂解灭活疫苗纯化工艺的开发

Development of Purified Technics for Influenza Split Inactivate Vaccine

负载自体肿瘤细胞裂解物的DC疫苗联合CIK治疗晚期肾癌的临床观察&附10例报告

Efficacy of Autologous Renal Tumor Cell Lysate-loaded Dendritic Cell Vaccine in Combination with Cytokine-induced Killer Cells on Advanced Renal Cell Carcinoma-a Report of Ten Cases

光动力疗法制备细胞裂解液作为肿瘤疫苗，以光敏剂浓度，能量密度和PDT细胞的数量（免疫剂量）作为考察因素，优选疫苗制备的最适条件。

Prepare tumor vaccine / cell lysates by PDT , with concentration of photosensitizer , energy density and the number of PDT cells ( immune dose ) to optimize the PDT cell vaccine preparation conditions .

比较以凋亡肿瘤细胞和肿瘤细胞裂解物制备疫苗的效果

The research of tumor vaccine with apoptotic tumor cell and tumor cell lysate

裂解剂的残余含量是流感病毒裂解疫苗的主要质控指标之一。

Split reagent content was one of the main standards used for controlling influenza vaccine quality .