神经氨酸酶抑制剂

介绍近年来临床主要应用的2类抗流感病毒药物：M2离子通道蛋白抑制剂和神经氨酸酶抑制剂的作用机制、临床应用特点及不良反应，并简要介绍了其他一些在我国常用的抗流感病毒药物。

M2 protein inhibitors and neuraminidase inhibitors are the two main anti-influenza drugs available in clinical use . In this paper , their mechanism of action , clinical efficacy , adverse reactions as well as other anti-influenza drugs commonly used in China are introduced .

流感病毒神经氨酸酶抑制剂构效关系研究

Studies on Structure-activity Relationship of Influenza Neuraminidase Inhibitors

以H5N1禽流感病毒神经氨酸酶抑制剂为例，应用FB-QSAR方法建立了H5N1神经氨酸酶抑制剂的预测模型，对于未来合理药物设计提供更多的关于分子结构和性质的信息。

The FB-QSAR approach can remarkably enhance the predictive power and provide more structural insights into rational drug design . As an example , the FB-QSAR is applied to build a predictive model of neuraminidase inhibitors for drug development against H5N1 influenza virus .

FCL-1与乙酰基糖类和唾液酸类糖蛋白均具有较强的结合特性。唾液酸类神经氨酸酶抑制剂的研究进展

In HA-inhibition assays performed with several carbohydrates and glycoproteins FCL-1 showed a distinct specificity for acetyl group in carbohydrates and Sia-group in sialoglycoconjugates . Progress of Neuraminidase Inhibitors Related to Sialic Acid

唾液酸类神经氨酸酶抑制剂的研究进展

Progress of Neuraminidase Inhibitors Related to Sialic Acid

酰基硫脲类流感病毒神经氨酸酶抑制剂的设计与合成及虚拟筛选

Design , Synthesis and Virtual Screening of Acyl Thiourea Derivatives as Influenza Neuraminidase Inhibitors

抗病毒药物，如神经氨酸酶抑制剂，被广泛用于治疗流感。

Antiviral drugs , such as neuraminidase inhibitors , are widely used to treat influenza .

抗流感神经氨酸酶抑制剂的研究进展

Research progress of neuraminidase inhibitors for anti-influenza

帕拉米韦属神经氨酸酶抑制剂。

Peramivir is a neuraminidase inhibitor .

根据化学结构的不同，综述各类神经氨酸酶抑制剂的作用机制及构效关系。

The acting mechanism and structure-activity relationship of each kind of influenza neuraminidase inhibitors with dissimilar structures were reviewed .

对结构基于唾液酸类的神经氨酸酶抑制剂在抗流感病毒药物研究中的进展进行了综述。

The recent progress of the research of neuraminidase inhibitors related to sialic acid in the control of influenza is reviewed .

神经氨酸酶抑制剂防治甲、乙型流感的疗效：随机对照试验的系统性回顾及汇总分析

Effectiveness of neuraminidase inhibitors in treatment and prevention of influenza A and B : systematic review and meta-analyses of randomised controlled trials

由于禽流感病毒对离子通道抑制剂、神经氨酸酶抑制剂等化学药物容易产生抗性，这将都会影响疾病的控制效果。

The resistance of avian influenza virus to chemotherapy agents ( ion channel inhibitor and neuraminidase inhibitor ) often influences the disease control effect .

这种药物有两类：1）烷胺类药物（金刚烷胺和金刚乙胺），2）流感的神经氨酸酶抑制剂（奥司他韦和扎那米韦）。

There are two classes of such medicines , 1 ) adamantanes ( amantadine and remantadine ), and2 ) inhibitors of influenza neuraminidase ( oseltamivir and zanamivir ) .