造血生长因子与受体结合后激活JAK，JAK发生自我磷酸化的同时也使受体磷酸化，继而通过SH2蛋白激活ras通路。
The JAKs are associated with the receptors and activated following ligand binding . The activated JAKs phosphorylate both themselves and the receptor subunits , and through SH2-containing proteins activate the ras pathway .
自我磷酸化