胰岛素受体家族

最近的研究工作表明，睾丸的分化受到胰岛素受体家族基因的调控，正常情况下SRY需通过两个不同的核运输途径使足够剂量的SRY蛋白进入细胞核调控性腺分化过程。

Recent studies show that testis differentiation requires insulin receptor family function in mice . SRY normally requires two distinct NLS-dependent nuclear import pathways to reach sufficient levels in the nucleus for gonadal differentiation .

目的观察17β-雌二醇和孕酮对人成骨细胞和人成骨肉瘤MG-63细胞胰岛素受体底物家族（insulinreceptorsubstrateIRS）表达的影响。探讨雌、孕激素对骨的作用机制。

Objective To investigate the effects of 17 β - estradiol ( E2 ) and progesterone ( P ) on the expression gene of insulin receptor substrate ( IRS ) family in cultured normal human osteoblast-like cells ( HOB ) and human osteosarcoma cell line MG-63 and its mechanism .

17β-雌二醇和孕酮对人成骨细胞胰岛素受体底物家族的作用

Effects of 17 β - estradiol and progesterone on insulin receptor substrate family in human osteoblasts