胰岛素受体底物

目的观察17β-雌二醇和孕酮对人成骨细胞和人成骨肉瘤MG-63细胞胰岛素受体底物家族（insulinreceptorsubstrateIRS）表达的影响。探讨雌、孕激素对骨的作用机制。

Objective To investigate the effects of 17 β - estradiol ( E2 ) and progesterone ( P ) on the expression gene of insulin receptor substrate ( IRS ) family in cultured normal human osteoblast-like cells ( HOB ) and human osteosarcoma cell line MG-63 and its mechanism .

目的：观察烧伤后胰岛素受体底物1（IRS-1）及其丝氨酸307和酪氨酸磷酸化的变化，探讨烧伤后胰岛素抵抗的分子机制。

Objective : To investigate the changes of insulin receptor substrate 1 ( IRS-1 ), Serine 307 and tyrosine phosphorylation of IRS-1 after burn , providing information for the molecular mechanism of insulin resistance after burn .

老龄大鼠肝脏和骨骼肌胰岛素受体底物-1及磷酸化蛋白激酶B的表达

Effects of Aging on the Expressions of Insulin Receptor Substrate-1 , Phosphate Protein Kinase B in Rat Liver and Muscle

胰岛素受体底物PH结构域相互作用蛋白结构和功能研究进展

Progress in the Studies on Structure and Function of Pleckstrin Homology Domain-Interacting Protein for Insulin Receptor Substrate

胰岛素受体底物1的PH结构域与PKC的结合

Binding of Insulin Receptor Substrate 1 PH Domain to Protein Kinase C

胰岛素受体底物（Insulinreceptorsubstrate，IRS）分子是胰岛素信号通路上的主要调节分子，在维持细胞正常的基础功能上扮演着重要角色。

Insulin receptor substrate ( IRS ) molecules are key mediator in insulin signaling and play a central role in maintaining basic cellular functions .

Ⅱ型糖尿病病人脂肪组织胰岛素受体底物1和含2个SH2结构的蛋白酪氨酸磷酸酶的蛋白表达

The protein expression of insulin receptor substrate-1 and protein tyrosine phosphatase with two src-homology ⅱ in the adipose tissue from type ⅱ diabetic patients

胰岛素受体底物（Insulinreceptorsubstrate，IRS）家族是胰岛素/类胰岛素生长因子信号系统上游通路的关键介导者，在维持细胞生长、分裂和代谢中起着重要作用。

Insulin receptor substrate molecules are key mediators in insulin / IGF signaling system and play a critical role in maintaining basic cellular functions such as growth , survival and metabolism .

通过减少胰岛素受体底物（IRS）蛋白的水平能够增加胰岛素受体活性时间、炎症时间和胰岛素水平，从而有助于降低胰岛素抵抗程度。

Prolonged activation of the insulin receptor , inflammation , and excessive insulin levels can induce insulin resistance by decreasing levels of insulin receptor substrate ( IRS ) proteins .

胰岛素受体底物-1（Insulinreceptorsubstrate-1，IRS-1）作为多位点的锚定蛋白，连接受体激酶和信号蛋白质，引起受胰岛素调节的许多细胞内的多种功能的活化。

Insulin receptor substrate-1 ( IRS-1 ) acts as a multisite docking protein that binds signal proteins and links the receptor kinase to a number of cellular functions that are regulated by insulin .

胰岛素受体底物分子（IRS）是调节胰岛素信号通路的关键物质，在维持细胞生长，分裂和代谢中起着重要作用。

Insulin receptor substrate ( IRS ) molecules are key mediators in insulin signal pathway which play an important role in maintaining basic cellular functions such as cell growth , division and metabolism .

目的研究不同程度感染大鼠骨骼肌胰岛素受体底物-1（IRS-1）及其丝氨酸（Ser307）磷酸化和酪氨酸（Tyr）磷酸化在胰岛素抵抗（IR）中的作用。

Objective To investigate the effects of insulin receptor substrate ( IRS ) - 1 and its serine ( Ser ) ~ 307 phosphorylation and tyrosine ( Tyr ) phosphorylation on insulin resistance in skeletal muscle cells in the state of sepsis .

目的：探讨变性高效液相色谱（DHPLC）在胰岛素受体底物2（IRS2）基因3′非翻译区单核苷酸多态性（SNP）检测中的应用。

Objective To explore the use of denaturing high-performance liquid chromatography ( DHPLC ) in detecting single-nucleotide polymorphisms ( SNPs ) of insulin receptor substrate-2 ( IRS-2 ) gene 3 ′ - untranslated region ( 3 ′ - UTR ) .

受体后的信号转导经过了一系列磷酸化和去磷酸化等途径，其中有胰岛素受体底物1（IRS1）、Shc蛋白、Ras蛋白以及磷酸肌醇3激酶（PI3K）等的参与。

The post receptor signal transduction consists of a series of receptor associated tyrosine protein kinase activated intracellular protein phosphorylation and dephosphorylation reactions , such as the phosphorylation of insulin receptor substrate 1 ( IRS 1 ), Shc , Ras and phosphatidylinositol 3 kinase ( PI3 K ) .

目的研究北京地区汉族人群胰岛素受体底物4（IRS4）基因密码子879cg多态性与2型糖尿病的相关性。

Objective To study the association of insulin receptor substrate-4 ( IRS-4 ) gene codon 879 c / g polymorphism with type 2 diabetes and its intermediate phenotypes in Chinese population in Beijing .

胰岛素受体底物1在烧伤后胰岛素抵抗中的作用

Role of insulin receptor substrate 1 in insulin resistance after burn

人成骨细胞胰岛素受体底物的表达

The Expression of Insulin Receptor Substrate in Human Osteoblast

胰岛素受体底物基因多态性与多囊卵巢综合征表型特征的关系

Relationship of Insulin Receptor Substrate Genotypes to Phenotypic Features of Polycystic Ovary Syndrome

胰岛素受体底物-1在子宫内膜癌中的表达

Expression of insulin receptor substrate-1 in endometrial carcinoma

胰岛素受体底物在宫内发育迟缓新生鼠肌肉组织中的表达

Expressions of Insulin Receptor Substrate Proteins in Muscle of Newborn Rats with Intrauterine Growth Retardation

我国小型猪品系胰岛素受体底物1基因外显子1的多态性分析

Polymorphism of insulin receptor substrate 1 gene exon 1 in three Chinese native miniature pig strains

17β-雌二醇和孕酮对人成骨细胞胰岛素受体底物家族的作用

Effects of 17 β - estradiol and progesterone on insulin receptor substrate family in human osteoblasts

主要观察指标：各组小鼠脑胰岛素受体底物1阳性细胞形态及分布。

MAIN OUTCOME MEASURES : Pattern and distribution of IRS-1 positive cells of mice in each group .

中国人2型糖尿病患者胰岛素受体底物-1基因变异的研究

A study on the mutation of insulin receptor substrate-1 gene in Chinese patients with type 2 diabetes mellitus

胰岛素受体底物影响小鼠前脂肪细胞和前成骨细胞分化的作用及机制

Functional and Mechanism Research of Insulin Receptor Substrate 1 on the Cell Differentiation in Mouse Pre-osteoblasts and Pre-adipocytes

目的：探讨西罗莫司对大鼠烧伤后胰岛素受体底物1丝氨酸307（IRS-1Ser307）磷酸化和胰岛素抵抗的作用。

Objective : To investigate the effects of sirolimus on IRS-1 phospho-Ser 307 and insulin resistance after burn in rats .

2型糖尿病大鼠胰岛素受体底物-2基因表达变化及中药的干预作用

The Variation of Gene Expression of Insulin Receptor Substrate-2 of Type 2 Diabetes Mellitus Rats and the Intervention of Herb

以上结果提示胰岛素受体底物1基因G972R位点多态性与中国人高甘油三酯血症无关联。

Conclusion These results suggest that the IRS 1 gene G 972 R polymorphism was not associated with endogenous hypertriglyceridemia in Chinese population .

骨骼肌胰岛素受体底物-1及其丝氨酸磷酸化与酪氨酸磷酸化在感染大鼠胰岛素抵抗中的作用

Effects of insulin receptor substrate-1 and its serine phosphorylation and tyrosine phosphorylation on insulin resistance in skeletal muscle cells in the state of sepsis : experiment with rats

代谢综合征组患者大网膜脂肪组织胰岛素受体底物1、葡萄糖转运蛋白4mRNA表达均显著低于对照组（P<0.01）。

The mRNA expression level of IRS-1 and Glut-4 in omental adipose tissue of the MS group was significantly lower than the control group ( P < 0.01 ) .