获得性耐药

收集细菌天然耐药性资料和现存获得性耐药表型资料编成专家规则，建立实验结果审核数据库。

Collecting data relevant to bacterial natural resistance and acquired resistance phenotypes , organizing them as expert rules , setting up database of results checking .

塞来昔布预防MCF-7细胞获得性耐药发生

Celecoxib prevents the acquired resistance of human breast cancer cell line MCF-7

氨甲蝶呤获得性耐药和DNA甲基化的相关性研究

The study on the relationship between acquired drug resistance to methotrexate and global DNA methylation

结核分支杆菌的初始、获得性耐药及复治后MDR-TB研究

A Study on the Primary and Acquired Drug Resistance of Mycobacterium tuberculosis and the Conditions of Post-retreatment MDR

雌激素消除后获得性耐药的高敏状态的共同特征是ERα表达增强、MAPK和PI3K信号活性增强。

The common characteristics of acquired drug resistance after estrogen deprivation are overexpression of ER α, increased activity of the pathways of MAPK and PI3K .

结论MDR基因过度表达在PHC天然性或获得性耐药起一定作用，且存在组织学差异。

Conclusions Overexpression of Pgp may be responsible for the intrinsic and acquired drug resistance of PHC . Histological differences exists in multidrug resistance ( MDR ) .

对RFP的获得性耐药率青年组和中年组均高于老年组（P0.001）。

The acquired resistance rate to RFP showed that both youth group and middle age group were higher than old age grou ( P0.001 ) .

人肝癌Bel（7402）细胞系天然耐药及5-FU获得性耐药的机理以及几种天然化合物逆转多药耐药的作用的研究

The Study of the Mechanism of Innate and 5-FU Acquired Resistance of Human Hepatocellular Carcinoma Bel_ ( 7402 ) Cell Line as well as Reversal of Multidrug Resistance by Natural Compounds

P-糖蛋白（P-glycoprotein，P-gp）过表达和微管蛋白基因变化引起紫杉醇耐药的报道已有很多，然而均不能完全解释肿瘤对紫杉醇的获得性耐药现象。

Overexpression of P-gp ( P-glycoprotein ) and alterations in the tubulin gene are frequently reported causes of paclitaxel-resistance . However , this evidence cannot yet fully explain the mechanisms responsible for acquired paclitaxel-resistance in human cancer .

在肿瘤化疗治疗的过程中发现在使用某种抗癌药物延长对癌症病人的治疗的同时导致了病人对多种抗癌药物产生获得性耐药，这就是所谓的多药耐药（MDR）。

During the course of cancer chemotherapy treatment , it has been found that prolonged treatment of carcinoma patients with certain anticancer medicines can result in an acquired resistance toward multiple drugs , which is known as multidrug resistance ( MDR ) .

在固定的诱导倍数（诱导MIC值/基础MIC值）下，比较两组的诱导耐药成功率、诱导周期，以分析LEV、AMX获得性耐药的难易程度。

The the success ratio and induction period between the two groups was compared to analyze the propensity of acquired resistance to LEV and AMX when fixed the induction multiple ( induced MIC / basic MIC ) .

甲氨蝶呤（Methotrexate，MTX）是治疗绒癌的首选药物，也是在绝大多数联合化疗方案中必需的药物，但MTX获得性耐药严重，单一MTX约30%患者将出现耐药。

Methotrexate ( MTX ) is a first-line and essential component in combined chemotherapy in the treatment of choriocarcinoma . However acquired drug-resistance is common and serious in choriocarcinoma . It is estimated that about 30 % of patients will develop drug-resistance if single MTX is used .

胰腺癌耐药细胞株SW1990/Fu产生获得性耐药机制的研究

Acquired multidrug resistance in pancreatic adenocarcinoma cell line SW1990 / Fu

获得性耐药率91%，获得性耐多药率39%，耐多药率逐年增加。

The rate of multidrug resistance was increased year by year .

初始耐药率及获得性耐药率有逐年上升趋势。

The initial and acquired drug resistance rates increased annually .

宫颈癌是全世界妇女中最常见的恶性肿瘤之一，由于肿瘤细胞的获得性耐药及化疗药物的毒副作用，往往影响宫颈癌综合治疗的总体效果。

Cervical cancer is one of most common malignant tumor of women worldwide .

成人获得性耐药结核病危险因素的病例对照研究

A Case-control Study on Risk Factor for Acquired Drug Resistant Tuberculosis of Adult

但大肠癌化疗中原发和获得性耐药现象很普遍。

But , primary and acquired treatment resistance is common in colorectal cancer .

胰腺癌细胞对5氟脲嘧啶和健择的获得性耐药机制的研究

The mechanism by which pancreatic cancer cells acquire drug resistance against 5-FU and gemcitabine

四川省获得性耐药结核病患者社会行为危险因素的研究

Study on socio - behavioral risk factors of acquired drug resistance of tuberculosis in Sichuan province

而绒癌耐药多数为获得性耐药，其耐药机制主要包括药理学机制和细胞机制。

Most of the drug resistance in choriocarcinoma is acquired , including pharmacological and cytological mechanisms .

目的探讨胰腺癌耐药细胞株SW1990/Fu产生获得性耐药的可能机制。

Objective To investigate the possible mechanism of acquired multidrug resistance in pancreatic adenocarcinoma cell line SW1990 / Fu .

很多监测研究证明的高敏感性，个别报告有医院获得性耐药株。

While most surveillance studies demonstrated high rates of susceptibility , several reports noted the emergence of polymyxin-resistant nosocomial pathogens .

在肿瘤化疗的过程中，耐药现象的存在，尤其是获得性耐药，严重阻碍了化疗药物的应用。

Resistance phenomena , especially acquired drug-resistance , have been severely hampering the applications of chemotherapeutics during chemotherapy of tumor .

获得性耐药率72.62%，4药全部耐药者占30.95%。

Acquired resistance rate was 72.62 % . The rate of acquired resistance to all the four drugs was 30.95 % .

北京基因型菌株与其他基因型相比是否在获得性耐药和高致病性基因上有选择性优势有待回答。

Whether Beijing genotype strain has a selective advantage over other genotypes in acquired resistance and higher pathogenicity remain to be answered .

目的：了解结核病总体耐药、初始耐药和获得性耐药的状况及其变化趋势，为评价我国结核病控制规划的实施效果，改进结核病防治措施，提供依据和参考。

Objective : To understand the status and trend of drug resistance of mycobacterium tuberculosis in China , and provide evidence for TB control strategies .

南非成年黑人结核病人中的原发性和获得性耐药：参加一项全国耐药连续监测规程的结果

Primary and acquired drug resistance in adult black patients with tuberculosis in South Africa : results of a continuous national drug resistance surveillance programme involvement

然而，这类化合物还存在水溶性低、获得性耐药、骨髓抑制和严重的胃肠道反应等缺点，促使人们寻找新的鬼臼毒素衍生物。

However , their low water solubility , acquired drug-resistance , myelosuppression and severe gastrointestinal disturbances promoted people to search for new derivatives of podophyllotoxin .

由于具有天然和获得性耐药，铜绿假单胞菌对很多抗菌药物耐药，给临床治疗带来很大困难。

Because of the natural and acquired drug resistance , Pseudomonas aeruginosa resistants to many antibiotics , and has caused great difficulties to the clinical treatment .