天然耐药

背景：已有研究报道肿瘤干细胞（CancerStemCells，CSCs）或肿瘤起始细胞对化疗天然耐药，或对化疗具有耐药性的肿瘤细胞表现出CSCs的表型特征。

Background : Cancer stem cells ( CSCs ) or tumor-initiating cells have been reported to be resistant to therapeutics and therapy-resistant cancer cells have been shown to manifest phenotypic properties of CSCs .

人肝癌Bel（7402）细胞系天然耐药及5-FU获得性耐药的机理以及几种天然化合物逆转多药耐药的作用的研究

The Study of the Mechanism of Innate and 5-FU Acquired Resistance of Human Hepatocellular Carcinoma Bel_ ( 7402 ) Cell Line as well as Reversal of Multidrug Resistance by Natural Compounds

屎肠球菌感染的发病率上升可能与获得了新的毒力因子有关，但是屎肠球菌的致病机制和毒力因子研究甚少，加上多重天然耐药的存在，临床治疗非常困难。

However , the mechanisms of pathogenesis and virulence factors of E. faecium are not yet well understood , and increasing multidrug resistance in enterococci has made it more difficult to treat with enterococcal infections .

目的为证明钙调蛋白的抑制剂三氟拉嗪和抗P-糖蛋白单克隆抗体（JSB-1）能协同逆转人肾癌的天然多药耐药（MDR）性。

Purpose To illustrate that the trifluoperazine ( TFP ) which is the calmodulin inhibitor and anti-P-gp monoclonal antibody ( JSB-1 ) can reverse multidrug resistance ( MDR ) of the human kidney cancer .

由于具有天然和获得性耐药，铜绿假单胞菌对很多抗菌药物耐药，给临床治疗带来很大困难。

Because of the natural and acquired drug resistance , Pseudomonas aeruginosa resistants to many antibiotics , and has caused great difficulties to the clinical treatment .