缺血半影区

早期康复训练对大鼠脑缺血半影区GAP-43和P38mRNA表达的影响

A study of the effects of early-recovery training on expressions of GAP-43 mRNA and p38 mRNA in ischemic penumbra in rats

确定缺血半影区的能力，可以帮助临床医师采用最优化治疗，同时降低在三小时时间窗后治疗的潜在并发症。

The ability to determine ischemic penumbra may allow clinicians to optimize therapy while decreasing potential complications of therapy past the3-h window .

免疫组织化学法测定脑组织缺血半影区Bcl2和Bax蛋白的表达。

The expression of Bcl 2 and Bax proteins in the ischemic penumbra were examined by immunochemical technique .

3针刺治疗组与非治疗组组间比较，针刺治疗组大鼠顶叶皮质和海马缺血半影区微血管数（MVC）明显增高，有显著性差异（P＜0.01）。

Significant difference of microvascular count between acupunctured-treated group and untreated group was found in cortex of parietal lobe and hippocampus ischemia penumbra ( P < 0.01 ), the former was much higher than the latter .

主要观察指标：①主要结局：脑缺血半影区生长蛋白Gap-43及突触素P38mRNA原位杂交检测结果。

MAIN OUTCOME MEASURES : ① Major outcomes : RT-PCR results of growth-associated protein Gap-43 and synaptophysin P38 mRNA at ischemic penumbra region .

甲基绿派诺宁染色：缺血半影区细胞数量减少，结构完整，可见到少数胞浆呈紫红色且胞核呈绿色的凋亡细胞。

There were a few apoptotic neurons in ischemic penumbra under Methyl Green Pyronin staining .

电针对脑梗塞大鼠缺血半影区微血管和神经细胞超微结构的影响

The effect of electric acupuncture on the capillary and the ultrastructure of neuron in the ischemic penumbra of infracted rats

再灌注治疗的目的是使灌注不足但仍存活的脑组织的血流量恢复正常（缺血半影区）（2-7）。

The goal of reperfusion therapy is restoration of normal CBF in hypoperfused yet viable brain tissue ( ischemic penumbra )( 2 – 7 ) .

功能性电刺激治疗对急性脑梗死大鼠运动功能和缺血半影区微管相关蛋白-2表达的影响

Effects of functional electrical stimulation on motor function and protein expression of microtube-associated protein 2 in the penumbra field of the rats with acute cerebral infarction

2针刺对脑梗塞大鼠顶叶皮质和海马缺血半影区因缺血而改变的神经细胞线粒体等超微结构有改善作用。

Acupuncture treatment may have a recovering effect on neuronal ultrastructure caused by cerebral ischemia in cortex of parietal lobe and hippocampus ischemia penumbra of cerebral infarct rats .

结果（1）电针治疗组与非治疗组组间比较，电针治疗组大鼠顶叶皮质缺血半影区微血管数明显增高，差异有显著性（P<0.01）；

Results ( 1 ) Significant difference of microvascular count in cortex of parietal lobe was found between acupunctured-treated group and untreated group ( P < 0.01 ) , the former was much higher than the latter .

局灶脑缺血恢复期半影区小胶质细胞可塑性变化和bFGF表达规律的研究

Study on the Plasticit Change of Neuroglial Cell and the Expressing Rule of bFGF During Convalescence of Focal Cerebral Ischemia Penumbra

手术14d后缺血中心区和半影区可见大量胶质细胞增生。

There was great deal of collagenocyte that appeared in ischemic center and penumbra region at postoperative 14 days .

缺血42天，半影区小胶质细胞数目趋于稳定。

The microglia in ischemia penumbra tend to stable .

结论：与神经重塑有关的Gap-43和P38mRNA在局部脑缺血再灌注后缺血半影区的表达十分活跃。

CONCLUSION : The expression of Gap-43 and P38 mRNA related to neural plasticity becomes active in post IR penumbra region .

p38MAPK在局灶性脑缺血大鼠缺血中心区和半影区的表达

Expression of p38 MAPK in cerebral ischemia core and penumbra in rats with focal cerebral ischemia

观察脑缺血急性期后，电针对脑梗塞大鼠缺血半影区（IP）nNOS免疫阳性神经元的影响，为探讨电针治疗脑梗塞中枢神经机制提供实验依据。

Objective : To observe the effect of electroacupuncture on nNOS-positive neurons in the ischemic penumbra of cerebral infarction rat after acute period of ischemia , and to supply experimental evidence for exploring central nervous mechanism of electroacupuncture in ischemic penumbra .