神经病理性疼痛

核因子-κB对神经病理性疼痛及其脊髓免疫炎症因子表达的调节

NF - κ B Regulation in Neuropathic Pain and Spinal Proinflammatory Cytokines Expression

鞘内泵入布托啡诺对神经病理性疼痛大鼠脊髓P物质表达的影响

Effect of intrathecal butorphanol pumping on the expression of spinal substance P in rats with neuropathic pain

cAMP反应元件结合蛋白与神经病理性疼痛

CAMP response - element binding protein and neuropathic pain

神经病理性疼痛大鼠背根神经节钠离子通道β亚基mRNA表达的变化

Changes in expression of sodium channel β subunit mRNA in dorsal root ganglion in a rat model of neuropathic pain

VEGF在神经病理性疼痛大鼠脊髓的表达及其对伤害性刺激反应的易化作用

The Expressions of VEGF in the Spinal Cords of Rats with Neuropathic Pain and the Facilitating Effects on Noxious Stimuli

另外，基于病理学特征，可将疼痛划分为伤害感受性疼痛（nociceptivepain）和神经病理性疼痛（neuropathicpain）。

In addition , based on pathological features , pain can be divided into nociceptive pain and neuropathic pain .

目的：神经病理性疼痛（neuropathicpain，NP）是由于躯体感觉系统的损伤或疾病所引起的疼痛。

Purpose : Neuropathic pain ( NP ) is a consequence of injury or disease affecting the somatosensory system .

参芪扶正注射液延缓CCI大鼠神经病理性疼痛的产生

Shenfu Injection postpones the production of neuropathic pain in CCI rats

本研究的目的是利用RNA干扰技术抑制DREAM基因表达，开展对神经病理性疼痛基因治疗的实验研究。

The objective of this study is to investigate the gene therapy of neuropathic pain by application of RNA interference by inhibiting the expression of DREAM gene .

PT诱发的神经病理性疼痛症状与背根神经节（dorsalrootganglion，DRG）初级传入神经元的毒性有关。

The neuropathic pain symptoms caused by PT are relevant to the neurotoxicity of dorsal root ganglion ( DRG ) primary sensory neurons .

结论DRG中钠离子通道β3亚基mRNA表达上调在神经病理性疼痛中起重要作用。

Conclusion The up-regulation of sodium channel β _3 subunit mRNA expression in DRG may play an important role in neuropathic pain .

IL-1β及GDNF与长春新碱引起的神经病理性疼痛有关。

The change of expression of IL-1 β and GDNF were involved in neuropathic pain evoked by vincristine .

已有实验证明，Gal及其受体参与了神经病理性疼痛的调节。

It has been showed that Gal and its receptors are involved in transmission and regulation of neuropathic pain .

结论：在脊髓水平K+ATP通道调节Mor对慢性神经病理性疼痛大鼠的镇痛作用。

Conclusion K + ATP channels can regulate the analgesic actions of morphine at the spinal cord level .

该文主要就GDNF和神经病理性疼痛的研究作一简要综述。

This paper provides an overview of the evolution of GDNF and neuropathic pain research in recent years .

目的建立L4脊神经切断大鼠慢性神经病理性疼痛模型，并初步评价其可靠性。

Objective To establish a neuropathic pain model by transection of L4 spinal nerve in rats .

研究发现，糖尿病小鼠的坐骨神经损伤后，表达Gal的神经纤维再生延迟，并可能加重了神经病理性疼痛。

A prior research showed a delayed regeneration of Gal axons in diabetic mice after nerve injury maybe enhance neuropathic pain .

阿米替林对神经病理性疼痛大鼠脊髓GLAST的影响

Influence of amitriptyline on GLAST in spinal cord of rat in neuropathic pain

目的评价慢性神经收缩损伤（CCI）和脊神经结扎（SNL）模型大鼠脊髓背角蛋白激酶Cγ及Cα表达的变化，以探讨其在神经病理性疼痛中枢敏化中的作用。

Objective To investigate the changes in the expression of protein kinase C γ and C α( PKC γ, PKC α) in the dorsal horn of spinal cord in a rat with neuropathic pain .

豆腐果苷对慢性神经病理性疼痛大鼠热痛觉过敏及脊髓背角p-CREB表达的影响

The effect of Helicid on thermal hyperalgesia and expression of p-CREB in spinal cord dorsal horn in a rat model of neuropathic pain

C3、C7、C14组分别为慢性坐骨神经紧缩性神经病理性疼痛（CCI）模型术后3、7、14d测痛阈取标本。

C3 , C7 , and C14 groups : the chronic sciatic nerve constriction ( CCI ) model was established , the mechanical pain threshold was measured and the samples were obtained on the 3rd , 7th , 14th postoperative day , respectively .

因此，小胶质细胞中的P2X4受体和细胞内信号介质有望成为神经病理性疼痛治疗的新靶点。

Thus , P2X4 receptors and the intracellular signaling mediators in microglia are promising therapeutic targets for the development of novel pharmacological agents in the management of neuropathic pain .

己酮可可碱能减轻神经病理性疼痛大鼠痛觉过敏的发展

Pentoxifylline attenuates the development of allodynia in rats with neuropathic pain

非特异性的免疫抑制剂，非甾体类抗炎药能改善神经病理性疼痛。

Non-specific immune suppression with non-steroid anti-inflammatory drugs attenuates neuropathic pain .

鞘内注射氟代柠檬酸对糖尿病大鼠神经病理性疼痛的影响

Effect of intrathecal fluorocitrate in rat model with painful diabetic neuropathy

神经病理性疼痛中代谢型谷氨酸受体5型的表达变化

Expression Changes of Metabotropic Glutamate Receptor 5 in Neuropathic Pain

神经病理性疼痛患者合并抑郁状态时对免疫功能的影响

The effect of depression on immunity of neuropathic pain patients

腰4脊神经切断大鼠慢性神经病理性疼痛模型的建立

Establishment of neuropathic pain model by transection of L_4 spinal nerve in rats

神经生长因子在糖尿病神经病理性疼痛大鼠脊髓和背根神经节中的表达

Expression of NGF in dorsal horn and dorsal root ganglion of diabetic rats

PI3K/Akt信号通路在大鼠糖尿病神经病理性疼痛中的作用

Role of PI3K / Akt signal pathway in diabetic neuropathic pain in rats