疾病易感基因

单核苷酸多态性在复杂性状疾病易感基因研究中的应用

Single nucleotide polymorphism in studying complex diseases susceptibility gene

基因组上的SNP位点及其相应单体型的信息已经广泛地应用于疾病易感基因定位和药物基因组学研究。

SNPs and haplotypes in the human genome have been widely used in the identification of disease-associated genes and the study of pharmacogenomics .

目的：研究先天性髋关节脱位与X，22，7号染色体之间有无连锁关系，也为进一步寻找疾病易感基因的全基因组扫描进行初步尝试。

Objective : To investigate genetic linkage between the phenotype of congenital dislocation of the hip ( CDH ) and genes located in chromosome 22,7 , X , and attempt initially process of the genome-wide scan for searching disease-susceptibility loci .

近几年，人类基因组序列和SNP的研究使这类多基因疾病易感基因的鉴定取得很大进展。

Recently , with the development of the studies on human genome sequences and SNPs , great progress has been made for the identification of the susceptible genes of complex diseases .

论疾病易感基因多态性与中医证候的多样性

Essay on Susceptible Gene Polymorphism of Disease and Variousness of TCM Syndrome

目的建立起孪生子数据库，掌握青岛市孪生子的分布情况，为长期动态观测孪生子的健康状况和各种慢性疾病易感基因的分析研究提供基础数据。

Objective To recruit monodidymus in Qingdao and set up monodidymus dataset to investigate their distribution . Basic data can be collected for the dynamic observation on monodidymus health and some sensible genes of varied chronic diseases .

全基因组关联研究作为一种发现复杂疾病易感基因的重要工具，已经帮助科学家们成功地找到了数干个与多种人类疾病相关联的遗传变异（单核苷酸多态性）。

Genome-wide association studies ( GWAS ) have emerged as an important tool for discovering susceptibility loci of complex diseases , and have successfully identified thousands of genetic variants ( single-nucleotide polymorphism , SNP ) associated with many human diseases .

六种与HLA相关联疾病的易感基因研究进展

Genome-wide scanning for susceptibility genes in researches on six HLA-associated diseases

系统生物学是采用系统科学的方法研究一个生物系统的一种大科学，为寻找精神分裂症等复杂疾病的易感基因提供一种新的思路。

System biology , which use systematic science principal to explore the whole system , can provide a new approach to study the genetic causes of schizophrenia .

目的探讨肾小球疾病发生及发展与HLA等位基因的关系，寻找肾小球疾病HLA易感基因。

Objective To study the relation of renal corpuscle disease ' occurence and development between HLA gene and find renal corpuscle disease HLA gene which episode easily .

近年大量研究表明，细胞毒T淋巴细胞相关抗原4（CytotoxicTlymphocyte-associatedantigen4，CTLA-4）基因多态性与诸多自身免疫性疾病的发生风险可能相关，因而被确定为自身免疫性疾病的候选遗传易感基因。

Recently , the gene encoding cytotoxic T lymphocyte associated antigen 4 ( CTLA-4 ) has been suggested as a candidate gene conferring susceptibility to autoimmunity .