母系遗传

通过主成分分析，证明贵州从江侗族与其他的壮侗语族人群相聚，母系遗传结构复杂，无C单倍群分布可能为该民族特征之一。

The matrilineal genetic structure of Dong of Guizhou is complicated .

西南地区母系遗传性耳聋家系的线粒体DNA分析

Mitochondrial DNA Mutations in Matrilineal Nonsyndromic Deafness Pedigrees of Southwest China

母系遗传性耳聋线粒体DNA突变分析

Mutational Analysis of Mitochondrial DNA in Familes with Maternally Inherited Hearing Loss

线粒体DNA在家鹅中也遵循严格的母系遗传。

Mitochondrial DNA of geese was also maternal inherited .

母系遗传氨基糖苷类抗生素致聋家系的线粒体DNA突变分析

Mutation Analysis for Mitochondrial DNA in a Chinese Pedigree with Maternally Inherited Aminoglycoside Antibiotic-Induced Deafness

人类仅能从母亲身上遗传线粒体DNA（线粒体DNA是严格的母系遗传），所以只有母系血统能使用追踪线粒体DNA的方法。

People inherit mitochondria only from their mothers , which is why only the female line of descent can be tracked using them .

应用DNApooling技术对一例母系遗传非综合征耳聋大家系进行全基因组扫描

Screening the Whole Genome of an Extensive Matrilineal Nonsyndromic Sensorineural Deafness Family by Using DNA Pooling

一个母系遗传非综合征耳聋大家系及mtDNA12SRRNA基因突变研究

An extensive matrilineal nonsyndromic sensorineural deafness family and mtDNA 12S rRNA gene mutation

方法应用PCR和DNA序列分析技术，对一个有明确氨基糖苷类抗生素应用史的母系遗传耳聋家系共18人（包括聋人和听力正常者）的线粒体DNA进行研究。

Methods The mutation of mitochondrial DNA from all 18 family members of a chinese pedigree with maternally inherited aminoglycoside antibiotic-induced deafness was detected by PCR and DNA sequencing .

方法选择常染色体上365个短串联重复序列标记，应用DNApooling方法对一母系遗传性聋家系进行全基因组扫描。

Methods Whole genome-wide scanning was performed to analyze the 365 short tandem repeats in a deaf pedigree with maternal inheritance using DNA pooling strategy .

线粒体DNA（mtDNA）由于自身比较独特的遗传特性（母系遗传、缺乏重组和进化速率高）而被广泛地应用于人类群体的起源和演化研究。

Owing to its high evolution rate , lack of recombination and maternal inheritance , mtDNA has been extensively used in unraveling the genealogical history of our species .

线粒体拥有自己的dna并仅通过母系遗传，因此，替换母系（即有高风险传递这些疾病的人）卵细胞中有缺陷的线粒体就可以避免伤及儿童。

Mitochondria have their own DNA and are inherited only from the mother , so replacing defective mitochondria in eggs from mothers who have a high risk of passing on such diseases could spare the children .

目的Leber遗传性视神经病变（Leberhereditaryopticneuropathy，LHON）是一种主要累及视盘黄斑束纤维，导致视神经退行性变的母系遗传性疾病。

Objective Leber hereditary optic neuropathy ( LHON ) is a maternally inherited disease characterized by a bilateral optic neuropathy .

母系遗传糖尿病中线粒体tRNA~（leu（UUR））基因突变的研究

The mitochondrial tRNA leu ( uur ) gene mutation in maternally inherited diabetes mellitus

结论AMD可能与由母系遗传所致的mtDNA3243点突变无关。

Conclusion It is suggested that mtDNA 3243 point mutation due to maternal inheritance might be not concerned with both wet form AMD and dry form AMD .

线粒体DNA（mtDNA）为母系遗传，其基因间很少重组，所以可以反映出母系的进化历史，这样线粒体一个基因就可以代表整个线粒体基因组的变异情况。

Since mitochondrial DNA ( mtDNA ) is maternal inheritance , seldom recombination between them , and one of the mitochondrial genomes may represent the whole variation , they can be used to determine the molecular phylogeny .

目的检测1555A→G突变在西南地区母系遗传性非综合征性耳聋家系中的发生率，探讨其听力学特征，为建立相应的基因诊断方法提供依据。

Objective To identify the incidence of the 1555 A → G mutation and explore the audiological features of pedigrees with matrilineal non syndromic deafness in Southwest of China so as to provide the theoretical evidence for establishing the method of gene diagnosis .

结合mtDNA具有的母系遗传方式的特点，这一结果提示：常用的实验用近交系小鼠形成中可能只有1种雌性血统起了作用。

Because of maternal mode of inheritance of mtDNA , the results indicate that only one female lineage contributed to the formation of all these common inbred strains of mice .

结果该家系显示为典型的母系遗传，先证者的临床表现为典型的LHON患者表现；

Results The family history was consistent with a maternal inheritance and the proband exhibited a typical clinical feature of LHON .

Leber遗传性视神经病是由于线粒体基因突变导致的母系遗传性常见致盲眼疾。

Leber 's hereditary optic neuropathy ( LHON ) , a common blinding disease , is a maternally inherited degeneration of the optic nerve caused by point mutations of mitochondrial DNA .

部分2型糖尿病亚型，如成熟早发型糖尿病（MODY）和母系遗传的耳聋型糖尿病（MIDD）、高胰岛素原型糖尿病等，只占所有2型糖尿病病人的5%。

The subtypes of diabetes mellitus , e.g. maturity-onset diabetes of the young ( MODY ), maternally inherited deafness and diabetes ( MIDD ), hyperproinsulinemia diabetes , may represent only 5 % of all patients with type 2 diabetes forms .

结论由于这类病人具有母系遗传、耳聋、进行性胰岛素分泌不全等特征，临床上可将这一类型的糠尿病分为一种新亚型－MIDD。

Conclusion Since the patients have the clinical characteristics of maternal transmission , hearing loss and impaired insulin secretion , we conclude that maternally inherited diabetes and deafness ( MIDD ) is a new diabetes subtype associated with a single mitochondrial mutation .

中国味道的国际大家庭线粒体病的母系遗传

The international family in Chinses style Maternal inheritance of mitochondrial diseases

母系遗传性聋大家系全基因组扫描研究

Whole genome-wide scanning for a large pedigree with matrilineal deafness

母系遗传药物性聋与非综合征性聋的分子遗传机制与功能研究

Molecular Mechanism and Functional Characterization Associate with Maternally Inherited Aminoglycoside-induced and Nonsyndromic Deafness

一母系遗传非综合征型感音神经性耳聋线粒体基因突变分析

Sequence analysis of mitochondrial DNA mutations in a maternally transmitted non-syndromic deafness family

一母系遗传非综合征耳聋大家系的临床特征和病因学研究

Clinical character and etiological study of a large family with maternally inherited non-syndromic deafness

云南僰人源流的父系和母系遗传研究

The Genetic Study on the Patrilineal and Matrilineal Origin of the Bo People in Yunnan

目的探讨母系遗传性非综合征性耳聋的听力学特征及分子遗传学机制。

Objective To explore audiological features of matrilineal non syndromic deafness and its molecular mechanism .

方法收集两个母系遗传非综合征型耳聋家系和14个感音神经性耳聋散发病例；

Methods Blood samples were obtained from 2 pedigrees and 14 sporadic patients with SNHL .