非竞争性抑制

槲皮素竞争性抑制CYP3A2右美沙芬N脱甲基反应，非竞争性抑制CYP2E1氯唑沙宗6羟化反应。

QU exhibited competitive inhibition of CYP3A2 dextromethorphan N-demethylation reaction and expressed noncompetitive inhibition of CYP2E1 chlorzoxazone-6-hydroxylation reaction .

同时选择非竞争性抑制进行了试验验证和常数求解。

At the same time , inhibition kinetic constant of noncompetitive inhibition is testified by force of a experiment .

最佳pH值为7.7。结论：高浓度表面活性剂对酶表现非竞争性抑制作用；

Optimum pH is 7.7 . Conclution : Higher concentration of surfactant showed a non - competitive inhibition on the lipase activity ;

氯仿－乙醇混合液（2∶3／v∶v）对该酶的抑制属于非竞争性抑制。

The inhibition of the mixture of chloroform-enthanol ( 2 ∶ 3v / v ) on this enzyme is noncompetitive .

Dox非竞争性抑制Tet-激活的P-gpATPase活性。

Moreover , Dox inhibited Tet-activated P-gp ATPase activity in a noncompetitive manner .

实验表明：GM1对兔红细胞膜钠泵有激活作用，而GM3则为非竞争性抑制作用，Vm发生改变而Km不变。

The results indicate that GM1 activates the sodium pump , but GM3 is a non-competitive inhibitor of the sodium pump in rabbit red cells .

动力学研究表明，在不同Na~+、K+浓度对，GM3对Na~+、K~+-ATP酶的抑制作用，均呈非竞争性抑制。

Kinetics studies of Na + , K + - ATPase showed that GM3 acted as a non-competitive inhibitor when the concentrations of Na + , K + and ATP changed .

Cl－对底物CDNB有竞争性抑制作用，对GSH是非竞争性抑制作用；

The kind of inhibition by Cl - is competitive for CDNB and non competitive for GSH , respectively .

结果：大豆皂苷具有很强的α葡萄糖苷酶抑制作用，且表现为非竞争性抑制作用。

Results : Soyasaponins showed potent inhibitory activities against α - glucosidase .

酶底物动力学分析表明，马桑内酯对该酶的抑制属非竞争性抑制。

The enzyme substrate kinetic analysis indicated that it was the noncompetitive inhibition .

葡萄糖的存在对纤维素酶产生非竞争性抑制作用。

The existence of glucose brings non-competitiveness inhibition .

结果表明：野靛碱和苦豆碱对羧酸酯酶活性有显著的抑制，为可逆抑制类型的非竞争性抑制作用；

The results indicate that cytisine and aloperine could inhibit carboxylesterase activity through non-competitive inhibition .

连续搅拌反应器中产物&底物非竞争性抑制动力学的无因次分析

Non-dimensional Analysis of Non-competitive Substrate-Product inhibition Dynamics

结论枸杞多糖对α-葡萄糖苷酶具有较强的抑制作用，抑制机理为非竞争性抑制。

CONCLUSION LBP is a stronger α - glucosidase inhibitor . Its inhibitive mechanism is noncompetition inhibition .

结果表明，该耦合过程对产物非竞争性抑制的消除效果要优于竞争性抑制。

It has been found that the coupling process is more effective for elminating the product noncompetitive inhibition compared with the competitive one .

竞争性抑制和非竞争性抑制通过求解等速点底物浓度的方法求解抑制常数。

The inhibition kinetic constant about competitive and non-competitive inhibition is figured out by calculating the substrate concentration on the same speed point .

另一种血栓烷A2拮抗剂S145也非竞争性的抑制AA的上述反应。

Another TXA2 antagonist , S-145 also inhibited the both responses in a non-competive manner .

目前开发的P-gp抑制剂多数都是通过，直接与P-gp上药物结合位点作用，竞争性或非竞争性地抑制P-gp转运药物。

The majority of P-gp inhibitors are passed directly with P-gp drug binding sites , competitive or noncompetitive inhibit the function of P-gp .

结论异丙酚以非竞争性的方式抑制了DAT的转运功能，降低了多巴胺（DA）的再摄取，导致突触间隙DA浓度升高，从而增强了中枢多巴胺能神经信息的传递。

Conclusion Propofol inhibits the transport ability of DAT in a noncompetitive fashion and reduces the reuptake of dopamine , leading to elevation in DA concentration in the synaptic cleft and potentiation of dopaminergic neurotransmission in central nervous system .