整合酶

这是因为与蛋白酶和逆转录酶不同，整合酶在哺乳动物体内没有同源蛋白，因此有着更好的选择性。

Different from protease and reverse transcriptase , the integrase has no counterpart in mammalian body , thus it has a better selectivity .

HIV整合酶抑制剂体外筛选方法研究进展

The Methods for Screening HIV Integrase Inhibitors in vitro

天然化合物抑制HIV整合酶的研究进展

Advances in research of inhibiting HIV integral enzyme with natural compounds

在HIV的生命周期中，整合酶负责把病毒DNA整合到宿主细胞DNA中。

In the life cycle of HIV , IN aids the integration of viral DNA into the host chromosome .

其中两种药物是“整合酶抑制剂”，它可以阻止艾滋病病毒的遗传物质附加到宿主细胞的DNA中。

Two are " integrase inhibitors " that block the HIV genetic material from attaching to the host cell 's DNA .

用分子模拟方法研究HIV-1整合酶与抑制剂及病毒DNA的相互作用

Study on the Interactions between HIV-1 Integrase with Inhibitors and Viral DNA with Molecular Simulation Approaches

HIV-1整合酶（IN）通过依赖金属离子的两步反应将病毒DNA整合入宿主细胞中。

HIV-1 integrase ( IN ) integrates viral DNA into host cells through two steps metal ions-dependent reactions .

化学生物学导向的HIV-1整合酶抑制剂的发现和结构优化

Chemical Biology Directed Discovery and Structural Optimization of HIV-1 Integrase Inhibitors

基于结构的HIV-1整合酶抑制剂设计：计算机模拟方法

Structure-Based Design of HIV-1 Integrase Inhibitors : A Computer Modeling Approach

多羟基芳香族化合物对HIV-1整合酶的抑制作用多羟基黄酮醇类化合物的合成

Studies on the inhibition of polyhydroxylated aromatic compounds against HIV-1 integrase

HIV-1整合酶四聚体结构模拟及其活性位点分析

Modeling the Tetrameric Structure and Its Active Sites of HIV-1 Integrase

HIV-1整合酶蛋白的可溶性表达及功能研究

Prokaryotic Soluble Expression and Functional Study of HIV-1 Integrase Protein

用荧光方法检测HIV-1整合酶的体外活性

Detection of HIV-1 Integrase in vitro Activities using Fluorescent Technology

它能够选择性地抑制HIV-1整合酶两个催化功能中的链转移过程。

It can selectively inhibit strand transfer reaction of HIV-1 IN catalytic domain .

用分子对接方法预测HIV-1整合酶与金精三羧酸抑制剂的相互作用

Prediction of the Interaction of HIV-1 Integrase and Inhibitor Aurintricarboxylic Acid Using Docking

乌药茎中鞣质类成分及其抗HIV-1整合酶活性研究

Inhibitory activities of tannins extracted from stem of Lindera aggregata against HIV-1 integrase

用从头药物设计方法合理设计HIV-1整合酶抑制剂

Rational design of HIV-1 integrase inhibitors using a de novo drug design method

人源抗HIV-1整合酶单链抗体基因的构建及表达

Construction and expression of human anti HIV 1 integrase single chain antibody gene

HIV-1整合酶全酶结构模拟及其抑制剂筛选

The Structural Investigation of the HIV-1 Integrase Holoenzyme and the Screening of Its Inhibitors

HIV-1整合酶的纯化及活性检测

Purification and Assays for Activities of HIV-1 Integrase

HIV-1整合酶与抑制剂金精三羧酸复合物的分子动力学模拟

Molecular Dynamics Simulation on the Complex of HIV-1 Integrase and the Inhibitor Aurintricarboxylic Acid

HIV-1整合酶酶联免疫吸附试验及其抑制剂的研究

HIV-1 integrase enzymelinked immunosorbent assay and inhibitors

HIV-1整合酶单链抗体对整合酶生物学活性抑制作用的研究

Inhibition of enzymatic activities of HIV 1 integrase ( IN ) by the ScFv against IN

方法用I类整合酶基因通用引物对临床分离大肠埃希菌进行PCR检测，并对阳性菌株进行接合转移实验。

Methods To detect the gene of class ⅰ integrase by PCR with universal primer and conjugal transfer the plasmid of class ⅰ integron positive strains .

因此，研究整合酶与DNA和抑制剂的相互作用机理对于抗HIV-1药物的设计和改造具有重要意义。

Consequently , the study on the recognition mechanism of IN with inhibitors is important for the design and modification of the anti-HIV drugs .

HIV-1整合酶抑制剂的研究进展

Progress of HIV-1 Integrase Inhibitors

产生志贺样毒素的噬菌体φ297整合酶基因（int）的克隆和序列分析

Cloning and Analysis of Integrase Gene ( int ) of Shiga Toxin-producing Bacteriophages φ 297

利用噬菌体表面呈现技术制备HIV-1整合酶单链抗体的初步研究

A preliminary study on single chain fragments variable ( ScFv ) antibody against HIV 1 integrase by phage surface displaying

三联苯曲菌素还没有被广泛的研究但已报道显示其有抗氧化的活性，做为一种植物生长抑制剂，也显示了弱的抗HIV整合酶的活性。

Terphenyllin has not been extensively studied but has been reported to exhibit anti-oxidative activity , acts as a plant growth inhibitor and shows weak activity against HIV integrase .

本论文的研究为先导化合物的优化打下了坚实的基础，推进了靶向HIV-1整合酶与LEDGF/p75相互作用界面的药物发现进程。

This study laid a solid foundation for lead optimization and pushed forward the drug discovery process targeting IN-LEDGF / p75interaction .