整合素家族

IL-6与整合素家族细胞黏附分子在大鼠急性坏死性胰腺炎合并多器官损伤模型中的表达

Expression of IL-6 and integrin family cell adhesion molecules in acute necrotizing pancreatitis complicated with multiple organ injury in rats

CD11c/CD18是β2整合素家族成员之一，可与多种配体相互作用，在细胞间黏附和炎症反应中发挥生物学作用。

CD11c / CD18 is a member of β 2 integrin family . CD11c / CD18 can interact with many ligands and plays biological role in intercellular adhesion and inflammatory response .

整合素家族和ECM蛋白在皮肤的不同区域和发育不同时期的表达变化造成了不同的粘附环境，使皮肤能够更好地利用不同的细胞。

Expression of the two groups of molecules is variable during the different period in skin development , and in different parts of skin , in order to make the different adhesion environment , to utilize the different cells better .

结论：整合素家族细胞粘附分子LFA-1，Mac-1参与了急性坏死性胰腺炎继发多器官功能损伤的过程。

Conclusions : LFA - 1 and MAC - 1 should be correlated with the process of acute necrotizing pancreatitis associated with multiple organ injury and might play an active role in that process .

血管细胞粘附分子一1（VCAM-1）是一种属于免疫球蛋白超家族成员的细胞粘附分子，其配体主要是整合素家族的α4β1/VLA一4（非常晚出现抗原一4）。

Vascular cell adhesion molecule 1 ( VCAM - 1 ) is a member of immunoglobulin superfamily . The principal ligand for VCAM - 1 is integrin α 4 | β 1 / VLA - 4 ( very late antigen 4 ) .

目的研究伤口愈合过程中，粘附分子整合素家族在介导细胞与细胞外基质间的主要作用。

Objective To explore the potential role of integrin family in mediating the interaction between cells and extracellular matrix ( ECM ) during wound healing .

整合素家族是细胞表面重要的跨膜信号分子，它将细胞外基质如纤维粘连蛋白、玻连蛋白等与细胞内心肌肥厚信号通路联系起来，在心肌纤维化的发生发展过程中具有重要的意义。

Integrins are the important transmembrane receptor family , which link the extracellular matrix such as fibronectin and vitronectin to the hypertrophic response pathway of cardiac myocytes , plays an important role in the development of cardiac fibrosis via adhesion .

骨桥蛋白是整合素结合糖蛋白家族成员，作为一种细胞外基质介导多种生物学的行为。

Osteopontin is a member of the small integrin-binding glycoprotein family and it mediates varied kinds of biological behaviors as an extra cell matrix .