胆固醇代谢

神经细胞凋亡调节转化酶-1在LDL胆固醇代谢中的作用

Effect of NARC-1 on Low Density Lipoprotein Cholesterol Metabolism

目的：研究小檗碱（berberine，Ber）对胆固醇代谢的影响，并探讨其可能的作用机制。

Objective : To investigate the effects of berberine ( Ber ) on cholesterol metabolism and its mechanism . Methods : 1 .

高密度脂蛋白（Highdensitylipoprotein，HDL）在胆固醇代谢中起良性作用，能阻止动脉粥样硬化的形成及恶化。

On the other hand , high-density lipoprotein ( HDL ) can retard the progression of AS .

另外，p38还通过调节低密度脂蛋白受体基因表达和胆汁代谢对胆固醇代谢起关键作用。

Additionally , p38 may play a critical role in cholesterol metabolism by regulating expression of the LDLR gene and bile metabolism .

调节胆固醇代谢的新药物靶点LXR

New Drug Targets LXR for Cholesterol Control

APOB是低密度脂蛋白（LDL）颗粒的主要蛋白成分，在血浆LDL胆固醇代谢平衡中具有重要作用。

Apo B is the sole component of the low-density lipoprotein ( LDL ) particles and is thought to play an important role in the homeostasis of LDL cholesterol in plasma .

他汀类药物可能通过调节脑内胆固醇代谢、抑制载脂蛋白E表达、减少β淀粉样蛋白形成、降低卒中风险和增强胆碱能神经元功能等机制起到防治痴呆的作用。

Statins may prevent dementia through several mechanisms , such as regulation of cholesterol metabolism , inhibition of apolipoprotein E expression , inhibition of β - amyloid formation , reduction of stroke risk , and enhancement of cholinergic neuronal function .

今年，陈晓伟凭借在胆固醇代谢方面的研究在竞争中脱颖而出，获得了在美国国家卫生研究院（NationalInstitutesofHealth，简称NIH）工作的机会。但陈晓伟计划返回中国，回到他的本科学校——北京大学。

Mr. Chen , whose work on cholesterol metabolism helped him win a job competition this year at the National Institutes of Health , is instead making plans to return home to China and his undergraduate institution , Peking University .

结论：（1）内毒素、干扰素在mRNA和蛋白双重水平下调SRβ1的表达，明显降低SRβ1调节胆固醇代谢的作用。

Conclusion : ( 1 ) LPS and IFN-gamma down-regulates SR - β 1 expression at mRNA and protein levels ; ( 2 ) LPS and IFN-gamma remarkably disturbs the effect of SR - β 1 on cholesterol scavenging in macrophages ;

因此，Ezetimibe抗动脉粥样硬化作用的可能机制为：调节胆固醇代谢与转运、抑制炎症反应、抑制细胞生长增殖等。

Therefore , the possible mechanisms of ezetimibe to inhibit atherosclerosis are regulating cholesterol transport and metabolism , inhibiting inflammatory response and cell proliferation .

小檗碱对胆固醇代谢及肝脏Insig-2基因表达的影响

Effects of berberine on cholesterol metabolism and Insig-2 gene expression of hyperlipidemic rats

背景：研究发现，氧化物酶体增殖物活化受体（PPARs）是调控巨噬细胞胆固醇代谢的关键核受体。

Background With the deeper understanding of peroxisome proliferator-activated receptors ( PPARs ), Several studies have indicated that PPARs are important nuclear receptors that regulate macrophage cholesterol metabolism .

目前研究结果显示肺炎衣原体C.pn能破坏巨噬细胞内胆固醇代谢稳态而诱导泡沫细胞的形成。

Chlamydia pneumoniae ( C.pn ) infection may disturb the homeostasis of intracellular cholesterol metabolism which can lead to foam cell formation .

结论三产地ANBE都具有较强的纠正高脂蛋白血症脂蛋白-胆固醇代谢紊乱和抗脂质过氧化作用，此作用产地间差别不大。

Conclusion This study indicated that effects of ANBE from three areas on regulation of serumal lipid are obvious , and the effects of ANBE from different areas have no obvious imparities .

hB1F（NR5A2）能够调控多种靶基因和某些重要转录因子基因的转录，在生物体胆固醇代谢的平衡调控以及其他多种生理活动中具有重要作用。

It was revealed that hB1F ( NR5A2 ) could regulate the transcriptions of a number of target genes as well as those of several critical transcription factor genes . Moreover , it played essential roles in the regulation of cholesterol homeostasis and various physiological pathways .

胆囊结石中胆固醇代谢变化的实验研究

Changes of cholesterol metabolism in cholesterol gallstone formation in the rabbit

结论：①脾切除可诱发胆固醇代谢失调。

Conclusion : ① Splenectomy causes disorder of CHOL metabolism .

大豆活性肽对大鼠体内高胆固醇代谢的影响

Effect of soybean peptides intake on metabolism of cholesterol in hypercholesterolemic rats

酵母培养物对肉鸡机体抗氧化和胆固醇代谢的影响

Study of Yeast Culture on Anti-oxidation and Cholesterol in Broilers

膳食纤维与不同蛋白质联用对大鼠胆固醇代谢的影响

The Interaction of Protein and Dietary Fiber on Lipid Metabolism in Rats

高密度脂蛋白&胆固醇代谢紊乱与糖尿病血管并发症

High density lipoprotein-cholesterol metabolism in diabetics with vascular complications

胆固醇代谢平衡调控的分子机理

Molecular Mechanisms in the Regulation of Cholesterol Metabolic Homeostasis

缺乏抗坏血酸对豚鼠胆固醇代谢的影响

Effect of ascorbic acid of deficiency on the cholesterol metabolism in guinea pig

普罗布考对高密度脂蛋白胆固醇代谢的影响及其作用机制

Effects of probucol on the metabolism of high density lipoprotein cholesterol and their mechanism

丹参和山楂提取物含药血清对胆固醇代谢的影响

Effects of serum-drug of Radix Salviae Miltiorrhizae and Fructus Crataegi extracts on cholesterol metabolism

与胆固醇代谢障碍有关的组织细胞增多症，通常发生在年轻人身上。

Histiocytosis associated with disturbance of cholesterol metabolism , occurs chiefly in young children .

提示胆固醇代谢的异常变化在胆囊结石中起作用。

It is suggested that abnormal cholesterol metabolism plays an important role in gallstone formation .

目的为研究脂肪酸对胆固醇代谢可能的分子机制。

Objective To investigate the molecular mechanism of the effect of fatty acid on cholesterol homeostasis .

降脂添加剂对肉鸡胆固醇代谢的影响

The Effect of the Cholesterol Synthesis Inhibitor on the Cholesterol and Triacylglycerol of Tissues in Broilers

易成石和抗成石小鼠肝脏胆固醇代谢调节酶的基因表达特征

Characteristics of mRNA levels of hepatic cholesterol metabolism regulatory enzymes in genetically gallstone-susceptible and resistant mice