胆盐

2株猪源乳酸菌对低pH值和胆盐耐受性及热稳定性研究

Survival of Two Lactic Acid Bacteria of Piglet Intestine under Low pH , Bile Salt and Heat Treatment

川芎嗪（由预新国际龙源药业有限公司提供，批号20041204）。方法：造模：Wistar大鼠饲喂动脉粥样硬化饲料（蛋黄粉10%、猪油5%、胆盐0.5%、基础饲料85%），喂服3个月。

METHODS : Model establishment : Wistar rats were administrated AS feeds ( including 10 % yolk powder , 5 % lard , 0.5 % bile salt and 85 % basic feed ) for 3 months .

胆盐诱发肝细胞凋亡及蛋白激酶c信号通道的作用。

Bile salt induces apoptosis of hepatocytes and the role of protein kinase C signal pathway in obstructive jaundice .

外源性胆盐、膳食脂肪对小鼠粪pH值和粪胆酸含量的影响

The Influence of Dietary Fat and Exogenous Cholate on Feces pH and Feces Cholic Acid of Mice

在耐胆盐试验中，试验组活菌数比对照组低2.06%（P＜0.05）。

In the bile salt treatment , the viable counts of B. licheniformis was 2.06 % less than in the control ( P0.05 ) .

乳杆菌耐胆汁、降解结合胆盐和同化胆固醇能力的研究本文比较了几种乳酸菌对胆汁酸盐的耐受性和pH值的残活能力。

Lactic acid bacterium were evaluated to determine the bile tolerance and low pH on the ability to survive in broth .

不同的菌株在添加了牛胆汁的MRS中生长速度具有明显差异，同化胆固醇能力也明显不同，而降解结合胆盐的能力没有明显区别。

There was significant variation among strains in growth in MRS supplemented with bile and also variation in the ability to assimilate cholesterol .

胆盐水解酶（Bilesalthydrolase，BSH，EC3.5.1.24）是微生物生长、繁殖过程中产生的一种代谢物。

Bile salt hydrolase ( BSH , EC 3.5.1.24 ) is a metabolite of growth and reproduce of microbe .

大豆黄酮、脱脂乳对猪源芽孢乳杆菌S1耐受酸和胆盐的影响

Effects of daidzein and skimmed milk on the tolerance of Sporolactobacillus S1 to low pH and bile salt

筛选过程当中，首要的指标是检测菌株对低pH值和对胆盐的抗性以及在发酵或非发酵乳制品当中的存活能力。

The first requirement we set for a candidate Lactobacillus and Bifidobacterium strains were resistance to low pH , resistance to bile and ability to survive in fermented and non fermented milks .

本文详细报导用付立叶变换红外光谱法研究去氧胆盐（DOC）和牛胰多肽（BPP）与DPPC脂质体的相互作用。

This paper reports the interaction of BPP with DPPC liposomes by FT-IR spectroscopy .

荧光定量PCR、RT-PCR方法分析肝组织胆盐输出泵（Bsep）、类法尼醇X受体（FXR）的表达；

Real-time PCR and RT-PCR were used to assess the expression of bile salt export pump ( Bsep ) and FXR .

结论：灌注肝动脉和冲洗胆管有助胆管细胞保存，8h内只要能够清除胆盐或降低胆盐浓度，即可产生相同的保护胆管效果。

Conclusions : perfusing hepatic artery and washing biliary tract benefit the preservation of biliary tract cell .

通过体外实验研究了大豆黄酮和脱脂乳对芽孢乳杆菌S1在不同pH值和不同浓度胆盐下存活能力的影响。

In vitro experiments were conducted to investigate the effects of daidzein and skimmed milk on the survival of Sporolactobacillus S1 under different pH and bile salt conditions .

结果发现，12株乳杆菌能够耐受pH值的范围为3.0～5.0，耐受胆盐的浓度范围为0.2~0.4%。

The results showed that lactobacillus were resistant to pH 3.0 ~ 5.0 , and tolerant to 0.2 ~ 0.4 % bile salts . The growth carve of strains was : slow – moving period .

结论术前应用胆盐和抗内毒素抗体可有效降低梗阻性黄疸患者围手术期血浆ET、IL-6及IL-8水平。

Conclusion Preoperative administration of oral bile salt and intravenous anti-endotoxin antibody could efficiently decrease the plasma levels of ET , IL-6 and IL-8 pre-and postoperatively in cases of obstructive jaundice .

结论亚致死性损伤菌在TSA上能够生长，而在含胆盐的单料和双料上则菌落数明显减少。

[ Conclusion ] The sub-fatal damage bacteria can grow on TSA but the colony counting of which decreases obviously on HC and DC .

A7菌株能耐受pH2.5的酸性环境和0.5%胆盐浓度，是耐酸性和耐胆盐较强的菌株，并且该菌株对嗜水气单胞菌具有很强的抑制作用。

The strain has tolerance to bile salt concentration of 0.5 % and pH2.5 ability .

有研究表明MRP2与胆盐的分泌有关。

It is reported that MRP2 is related with secretion of bile salt .

目的：对特发性婴儿肝炎肝内胆汁淤积患儿的BSEP基因进行筛查，初步探讨胆盐输出泵基因与特发性婴儿肝炎肝内胆汁淤积的关系。

Objective : To screen the BSEP gene in intrahepatic cholestasis of idiopathic infantile hepatitis patients .

通过对市售有代表性的6种胆盐进行分析得知，6种胆盐中皆只含有胆酸（CA）、去氧胆酸（DCA）2种有效成分。

After analyzing 6 kinds of representative commercial bile salts , we drew a conclusion that all kinds of bile salts only contain two effective constituents-cholic acid ( CA ) and deoxycholic acid ( DCA ) .

实验结果表明聚乙烯醇（PVA）和卵磷脂/牛胆盐是制备硬脂精SLM的较好的稳定剂。

The stabilities of the SLM stabilized with different stabilizers were also investigated , proving that polyvinyl alcohol ( PVA ) and soy lecithin / bile salt are good stabilizers for the SLM system .

方法：乳酸杆菌在不同pH值（pH2~4.5）和不同浓度胆盐（0.1%~0.3%）的MRS肉汤中培养4h后，测定其活菌数及存活率。

Methods : Culture the Lactobacillus in the MRS broth with different pH ( 2.0 ~ 4.5 ) and bile salt ( 0.1 % ~ 0.3 % ) at 37 ℃ for 4 hours then calculate the livability of Lactobacilli .

乳糖胆盐发酵管法检测大肠菌群准确、可靠，但24～36h才得结果。

Lactose and bilesalt fermentation method is a reliable and accurate method in detecting coliform group but the results are obtained 24 ~ 36h later .

0.10%的胆盐处理10min后，R2的存活率为对照组的11.17%，R4的存活率仅为对照组的3.31%。

The survival rates of R2 and R4 were 11.17 % and 3.31 % respectively after incubating in the medium with 0.1 % of bile for 10 minutes .

关于围产儿并发症的发生机制目前普遍认为：由于ICP时，胆盐沉积于胎盘，使绒毛间腔狭小，胎儿供血不足，从而导致胎儿缺氧甚至死亡。

An abnormal amniotic fluid with high rate of perinatal newborn 's neopathy . It was generally accepted that when the bile salts deposited in placenta , the interspace of villus became narrow and the placental blood flow was decreased .

目的：本研究旨在利用胆盐/磷脂混合纳米胶束（bilesalt-phosphatidylcholinemixednano-micelle，BS/PC-MM）系统解决冬凌草甲素的溶解性问题，并对其相关性质进行研究。

OBJECTIVE : The aim of current study was to prepare and characterize Bile salt-phosphatidylcholine mixed nano-micelle ( BS / PC-MM ) systems to enhance the solubility of the poorly water-soluble drug , oridonin .

结论梗阻性黄疸大鼠GHR的最大结合容量和结合能力均明显降低，可能与梗阻时TNFα等炎症因子的高表达、肝细胞胆盐蓄积等有关。

Conclusion The decrease of B max and binding power of liver GHR might be associated with the higher level of TNF α and other factors and the increased concentration of potentially toxic bile salts in hepatocytes of obstructive jaundiced rats .

试验菌株坚强肠球菌CB4-2和CB8-3等10株菌在耐酸（pH3）试验中能存活，耐胆盐（0.3%牛胆酸钠）试验中生长率大于3.0%。

10 strains can resist to acid ( pH3 ) . And , in the experiment of resistant to bile , the ratio of growth of 10 strains is surpass 3.0 % .

结果：单独使用时，胆盐Ⅲ号（BSⅢ）的促吸收效率最低，3h仅为11.8%，脱氧胆酸钠的促吸收率最高，3h为59.7%；

RESULTS : Three hours after the single administration of each absorption enhancer , the absorption rate of trypsin with the aid of the bile salt ⅲ was the lowest ( only 11.8 % ) and the deoxycholate sodium was the highest ( 59.7 % ) .