缺氧环境

目的：缺氧环境与化疗抵抗的发生和发展有密切的关系，HIF-1（乏氧诱导因子1）是细胞在乏氧状态下被激活的重要的转录因子。

Purpose : We have proved hypoxia conditions are connected with the occurrence and development of chemoresistance closely . Hypoxia inducible factor-1 ( HIF-1 ) is a critical transcription factor .

方法复苏冻存的HK-2细胞，采用传代后的第2-5代细胞进行实验，进行实验前用无血清DMEM培养细胞12h使细胞同步化。利用密闭的细胞培养罐模拟缺氧环境，并检测其缺氧效果。

Passages 2-5 cells were used for the experiment after twenty-four hours cell synchronization in serum-free DMEM . A sealed cell culture vessel was used to induced hypoxia in our experiment .

缺氧环境上覆水中的pH高于或略高于相同光照条件下的富氧环境；

PH of the overlying water in the anoxic environment was higher or a little higher than that in the aerobic environment with the same light condition .

目的：探讨HIF-1α减轻瘢痕内缺氧环境的机制。

Objective To explore the mechanism of hypoxia inducible factor 1 α( HIF-1 α) ameliorating the hypoxia in the course of scar maturation .

缺氧环境下核转录因子Sp1在体外培养的人视网膜色素上皮细胞中的表达

Expression of nuclear factor Sp1 in cultured human retinal pigment epithelial cells in vitro under hypoxic conditions

APS分解法运用厌氧细菌（在缺氧环境下大量繁殖）来消化、分解有机材料。

APS digestion uses anaerobic bacteria , ones that thrive in the absence of oxygen , to consume , to break down organic material .

结论：血管活性肽ET－1、ANP分泌可能对急、慢缺氧环境下的心血管系统功能及神经内分泌调节具有重要意义。

Conclusions : The changes in contents of vasoactive peptides , RT 1 and ANP , may play an important roles for regulation of cardiovascular functions at high altitude . $

实验结果表明：DRC能显著延长小鼠常压缺氧环境下的存活时间以及夹闭气管小鼠心电图消失时间；

DRC treatment prolonged the survival time of mice and the duration of electrocardiograph in trachea closed mice .

外源性BDNF在宫内缺氧环境中对胎盘及胚鼠血脑屏障通透性和脑细胞凋亡的作用及信号传导的研究

Permeability of Exogenetic BDNF Through Placental Barrier and Blood-brain Barrier in Rats with Transient Uteroplacental Ischemia and Its Effection on Apoptosis of Embryo Brain and Its Signal Pathways

控制PIH病情，减少孕妇并发症，胎儿适时脱离宫内缺氧环境，对改善围产儿预后致关重要。

It was very significant for improving the perinatal outcome to manage patients and decrease the complications and separate foetus from intrauterine anoxia condition at the right moment .

缺氧环境下4-DMAP形成高铁血红蛋白的药效学特征

Pharmacodynamics of ferrihemoglobin formation by 4-DMAP under hypoxic condition

有报道在缺氧环境下，HIF-1通过刺激靶基因HO-1的活性，减少炎症趋化因子的合成，减轻组织损伤。

It has been reported that in hypoxic conditions , HIF-1 reduce tissue damage by stimulating the activity of target gene-HO-1 , and then reducing the synthesis of inflammatory chemokine .

结果显示：血管内皮细胞在缺氧环境中，上清液和细胞匀浆中MDA含量明显增加（P<0.001），加入不同浓度川芎嗪后均可阻止上述现象的发生。

The results showed that the MDA level in supernate of culture media and cell homogenate increased significantly ( P < 0.01 ) when the cell was cultured under hypoxic environment , and added various concentrations of tetramethylpyrazine could prevent this phenomenon .

随后人GRP94启动子克隆了荧光素酶基因上游区且缺氧环境中活性增强。

The human GRP94 promoter was then cloned upstream of the luciferase gene and showed enhanced activity in hypoxic conditions .

结果：不同剂量的He-Ne激光照射妊娠母鼠，其子代的体重、学习记忆力、耐寒能力和缺氧环境适应能力有所不同。

Result : After gestation mice are irradiation by He-Ne laser of different dosage , its filial generation in avoirdupois , recall ability of study , ability of bear cold and the adaptability of circumstance in lacking oxygen are different .

方法：取培养12d的海马神经元，分为对照组和腺苷组，同时于缺糖缺氧环境中培养0.5-4h后取出，立即更换原神经元培养液在常氧下继续培养24h。

METHODS : The control and adenosine-treated hippocampal neurons cultured for 12 d were exposed to oxygen-glucose deprivation environment for 0.5-4 h and then cultured with original medium in normoxia for 24 h .

低氧诱导因子1α（HIF-1α）是在低氧诱导下产生的一种具有转录活性的因子，它可以激活一系列目的基因，使组织和细胞耐受或改善缺血缺氧环境。

Hypoxia inducible factor 1 α( HIF-1 α) is a transcription factor which is expressed when cells are subjected to hypoxia . HIF-1 α can activate a serial of target genes , which are essential for tissue cells to tolerate and ameliorate hypoxia environment .

把培养12d的大鼠海马神经元分为对照组和rhIL6组，同时于缺氧环境（90%N2+10%CO2）中培养2、4h后，再于常氧培养箱内复氧培养24和72h。

The control and rhIL 6 treated hippocampal neurons cultured for 12 d were exposed to anoxia environment ( 90 % N 2 + 10 % CO 2 ) for 2 and 4 h , and then were reoxygenated for 24 and 72 h.

缺氧环境下硫酸盐还原对反硝化过程影响的特性试验研究

The influence of sulfate reduction on denitrification under anoxic condition

缺氧环境及地球化学判识标志的探讨&以鄂尔多斯盆地为例

The Discussion on Anoxic Environments and Its Geochemical Identifying Indices

低温低压缺氧环境对血清甲状腺素的影响

Effects of hypothermia and hypoxia on blood serum thyroxin level

中下扬子地区二叠纪缺氧环境研究

Study on Anoxic Environments of Permian in the Middle and Lower Yangtze Region

高原缺氧环境成年男性精子的计算机辅助分析

A computer-assisted semen analysis of mature males living in hypoxia environment at high altitude

烧伤后瘢痕内缺氧环境的变化

Changes of hypoxic environment in burn scars

目的探讨瘢痕内缺氧环境减轻的机制。

Objective To explore the mechanism of hypoxic environment lessening in the course of scar maturation .

对缺氧环境下硫酸盐还原对反硝化脱氮过程影响进行了试验研究。

It has been conducted an experimental study on the effect of sulfate reduction on denitrification under anoxic condition .

绿原酸对缺氧环境下细胞内活性氧改变引起的凋亡的作用，目前还不清楚。

Chlorogenic acid inside cells to anoxic environment caused by ros change the role of apoptosis , is unclear .

脑源性神经营养因子在宫内缺氧环境中对胎盘及血脑屏障通透性的实验研究

Study on permeability of brain derived neurotrophic factor through placental barrier and fetal blood brain barrier after transient uteroplacental ischemia

本实验通过在低压舱模拟高原的缺氧环境，研究了急性缺氧条件下，大鼠红细胞膜生物物理特性的变化。

The changes of the biophysical properties of the cell membrane of erythrocytes during acute hypoxia were observed in rats .

集中感染的组织坏死区往往提供缺氧环境，加速了感染的扩散。

Focal area of necrosis present in such tissue may also be hypoxic , accelerating the spread of the organism .