绝对生物利用度

po给药制剂绝对生物利用度为0.404±0.099。

Absolute bioavailability of ribavirin tablet was 0.404 ± 0.099 .

青藤碱在Beagle犬体内的药动学和绝对生物利用度研究

Study on pharmacokinetics and absolute bioavailability of sinomenine in beagle dogs

h，绝对生物利用度（F）2.0%±1.4%。

H , and the bioavailability was 2 . 0 % ± 1.4 % .

方法HPLC测定三七总皂苷混悬液大鼠鼻腔给药后血样中人参皂苷Rg1的浓度，考察药物在体内的动力学过程，并计算其绝对生物利用度；

Methods After administration , Rg1 concentration in the serum was analyzed by HPLC and the absolute bioavailability was calculated .

目的：建立Beagle犬血浆中氧化苦参碱的LCMS测定法，测定它的绝对生物利用度。

AIM : To establish LC-MS method in determination of oxymatrine in plasma of Beagle dogs and to investigate its absolute bioavailability .

计算所得TAL的绝对生物利用度为80%。

The calculated absolute bioavailability was 80 % .

目的通过实验明确大鼠口服LMWH的绝对生物利用度，为研制LMWH口服制剂提供依据。

Objective To provide significant basis for development of LMWH oral preparation though determination of absolute bioavailability of rats after oral LMWH .

结果三七总皂苷混悬液鼻腔给药后，Rg1在大鼠体内的过程符合二室模型，其绝对生物利用度为10356%；

Results The in vivo course of Rg1 in rats conformed to two-compartment model after intranasal administration of PNS suspension and the absolute bioavailability was 103.56 % .

绝对生物利用度（fabs）55.80%和43.84%；1缓释混悬液相对于溶液剂的生物利用度（frel）为127.29%。

Compared with galantamine solution , the relative bioavailability of sustained release suspension was 127.29 % .

由两种制剂的AUC0-12计算，灌胃制剂的绝对生物利用度为（5.0±1.5）%。

The absolute bioavailability was ( 5.0 ± 1.5 ) % .

目的：建立快速测定血清山莨菪碱（anisodamine，Ani）含量的方法，并测定家兔经灌胃（ig）及静注（iv）Ani的药代动力学参数和绝对生物利用度（Fabs）。

Objective : To build a rapid method for the separation and determination of anisodamine hydrochloride in rabbit 's serum , and determining the pharmacokinetic parameters after iv or ig Ani and its absolute bioavailability in rabbit .

口服1,6-二磷酸果糖的钙盐或钠盐的绝对生物利用度低

Extremely low absolute bioavailability after oral calcium or sodium fructose 1,6-diphosphate

由此可以得出盐酸甜菜碱在大鼠体内的绝对生物利用度为69.58%。

So the absolute bioavailability of betaine hydrochloride was 69.58 % .

美林洛尔在大鼠体内的绝对生物利用度为40.74%。

The absolute bioavailability of MELE in rats was 40.74 % .

微粉化后的马来酸多潘立酮的绝对生物利用度为40.43%。

The absolute bioavailability of micronized domperidone maleate is 40.43 % .

肌注后的绝对生物利用度为100%。

The absolute bioavailability after im injection was 100 % .

结论灯盏花乙素静注给药的药-时曲线符合三室模型，经剂量校正，灌胃给药的绝对生物利用度为2.20%。

The absolute bioavailability of scutellarin for oral administration was 2.20 % .

大鼠经灌胃、颈静脉交叉给药后，绝对生物利用度为3866%。

The absolute availability by intragastric administration was 38.66 % .

微粉化马来酸多潘立酮在犬体内的绝对生物利用度研究

Studies on Absolute Bioavailability of Micronized Domperidone Maleate in Dogs

大鼠口服低分子肝素的绝对生物利用度测定

Determination of Absolute Bioavailability of Rats after Oral Low Molecular Weight Heparin

绝对生物利用度为27.2%。

The absolute bioavailability was 27.2 % . 3 .

计算的绝对生物利用度为2.0%；

The absolute oral bioavailability of 1 was calculated to be 2.0 % ;

雾化吸入给药后的绝对生物利用度为7.38%。

The absolute bioavailability of HCPT after aerosol inhalation was 7 . 38 % .

柴葛口服液中葛根素在犬体内的药动学及绝对生物利用度

Pharmacokinetics and Absolute Bioavailability of Puerarin in Chaige Oral Liquid in Sera of Dogs

测得绝对生物利用度约为（726±156）%。

Absolute bioavailability was ( 72 6 ± 15 6 ) % for ig .

体内绝对生物利用度为12.0%，肝门静脉注射的绝对生物利用度为45.17%。

The absolute availability was12.02 % , the first pass effect of liver was45.17 % .

经剂量校正，口服给药的绝对生物利用度为（0.40±0.19）%。

The absolute bioavailability of scutellarin for oral administration was ( 0.40 ± 0.19 ) % .

以药物原形和尿药浓度评价黄芩苷在大鼠体内的绝对生物利用度为4.84%。

The absolute availability of baicalin in rat was 4.84 % according to the amount of baicalin .

结果：鼻腔喷雾剂和粉雾剂在不引起粘膜毒性作用下，绝对生物利用度分别为5.54%、8.36%。

Results : without cilium toxicity , absolute bioavailability of two formulation is 5.54 % . 8.36 % respectively .

灌胃给药吸收快，但吸收差，绝对生物利用度低，且药时曲线变化不规则。

After ig administration , the drug is absorbed rapidly but the absolute bioavailability is very low , and the changes of plasma concentration of scutellarin is not regulation .