噻托溴铵

目的：建立了测定噻托溴铵含量及有关物质的HPLC方法。

Objective : To established an HPLC method for the determination of tiotropium bromide and its related substances .

噻托溴铵在COPD大鼠气道炎症中的作用

Effects of Tiotropium Bromide on Airway Inflammation in a Rat Model with COPD

建立了HPLC法测定噻托溴铵含量。

HPLC method was established for the determination of tiotropium bromide .

吸入噻托溴铵治疗稳定期慢性阻塞性肺疾病（COPD）的疗效观察

Tiotropium Bromide Inhalation Therapy in Stable Chronic Obstructive Pulmonary Disease ( COPD ) Clinical Observation

RP-HPLC法测定噻托溴铵原料药中有关物质及其粉雾剂中主药的含量

Determination of the Related Substances in Tiotropium Bromide Crude Drug and the Content of Main Component in Tiotropium Bromide Dry Powder Inhalation by RP-HPLC

现有研究表明噻托溴铵能改善COPD的患者的多个终点事件，这就要求我们对噻托溴铵的长期疗效进行检验。

Previous studies showing that tiotropium improves multiple end points in patients with chronic obstructive pulmonary disease ( COPD ) led us to examine the long-term effects of tiotropium therapy .

在大宗临床试验中证实，长期规律使用噻托溴铵能明显持久改善稳定COPD患者肺功能、减轻活动时呼吸困难、明显提高运动耐量、改善生活质量。

Large clinical trials confirmed that Long-term regular using tiotropium bromide could significantly sustained improve the stable COPD patients ' lung function , reduce dyspnea on exertion , markedly improve exercise tolerance , improve the quality of life .

实验组吸入噻托溴铵干粉剂（18ug，每日1次），对照组口服茶碱缓释片，每次0.1，每日2次，治疗疗程都为12周。

Experimental group Tiotropium bromide inhalation powder dry ( 18ug , day 1 ), the control group of oral theophylline sustained-release tablets , each 0.1 , 2 times per day , treatment for 12 weeks .

噻托溴铵联合福莫特罗吸入治疗慢性阻塞性肺疾病

Effect of tiotropium bromide inhalation combined with formoterol inhalation on chronic obstructive pulmonary disease

噻托溴铵治疗稳定期中重度慢性阻塞肺疾病的临床研究

Clinical Study of Tiotropium Bromide in Treatment of Stabilization Period of Mid-severe Range COPD

吸入噻托溴铵干粉治疗稳定期慢性阻塞性肺疾病21例

Tiotropium bromide inhalation for 21 patients with chronic obstructive pulmonary disease at stable stage

目的：将噻托溴铵制备成胶囊型吸入粉雾剂，并对其稳定性进行研究。

Obstract : To prepare the Tiotropium Bromide Inhalation Powder and to study its stability .

噻托溴铵的支气管扩张作用比口服用茶碱均强，而不良反应较茶碱少。

Tiotropium Bromide bronchodilation effects are stronger than oral and less adverse reactions than theophylline .

噻托溴铵吸入粉雾剂的制备及稳定性研究

Preparation of Tiotropium Bromide Inhalation Powder

联合应用沙美特罗/氟替卡松与噻托溴铵对慢性阻塞性肺疾病肺功能的疗效

Therapeutic effect of salmeterol / fluticasone propionate combined with tiotropium bromide therapy for patients with COPD

本发明涉及一种乙醇化噻托溴铵结晶及其制备方法和药物组合物。

The present invention relates to alcoholated tiotropium bromide crystal and its preparation process and medicine composition .

目的：探讨噻托溴铵治疗老年人稳定期慢性阻塞性肺疾病疗效。

Objective : To study the clinical effect of tiotropium in treating stable chronic obstructive pulmonary disease .

噻托溴铵与沙美特罗替卡松对慢性阻塞性肺疾病稳定期疗效比较

Comparision of Therapeutic Effects between Tiotropium Bromide and Salmeterol / Fluticasone Propionate on Stationary Phases of Chronic Obstructive Pulmonary Disease

噻托溴铵治疗慢性阻塞性肺疾病随机双盲双模拟对照临床试验

Randomized double - blind double - dummy controlled clinical trial of tiotropium bromide in the treatment of chronic obstructive pulmonary disease

方法：对噻托溴铵进行了微粉化处理，以休止角、排空率和有效部位药物沉积量为指标对6种粉雾剂载体进行了处方筛选；

Methods : Tiotropium Bromide was further prepared . Formulations screened according to angle of repose , the rate of evacuation and the deposition of drug in effective site .

吸入噻托溴铵干粉与异丙托溴铵定量气雾剂治疗慢性阻塞性肺疾病的疗效与安全性比较

Comparison of tiotropium inhalation capsules and ipratropium metered dose inhaler in a randomized , double-blind , double-dummy , efficacy and safety study in patients with chronic obstructive pulmonary disease

而支气管扩张患者同样存在慢性气道炎症，存在可逆性气流受限，噻托溴铵在这些患者中长期规律使用，是否也能达到同样的疗效，目前这方面的临床研究较少。

Chronic airway inflammation and airflow limitation also exist in Bronchiectasis patients , but now there are little clinical observation can proved that Long-term regular using tiotropium bromide in these patients can get the same effect .