终点指标

结论：中医药国际化的关键是临床疗效的肯定，倡导参照循证医学评价方法，建立反映中医药整体调节优势的复杂、多维的终点指标评价体系。

Results : The key of internationalization of TCM is the affirmation of effects , it is proposed to establish complex , multidimensional endpoints outcome evaluation system which can reflect the advantage of whole regulation referring to EBM evaluation methods .

关于DCCT的试验设计，最初设定的终点指标中是不是不包括大血管合并症？

Regarding with the design of DCCT , macrovascular complications wasn 't included in predefined endpoints at first , right ?

此外工业实验还确定了云芝液体发酵的pH值、残糖浓度以及菌丝体形态等终点指标。

And the terminal criteria of the fermentation , such as pH value , the concentration of residual sugar and the shape of mycelia were designated .

PSADT作为一个重要的预后因子，可能在癌症特异性存活中作为一个辅助性终点指标；

PSADT is an important prognostic factor that may serve as an auxiliary end point for cancer-specific survival ;

目的研究炔雌醇（EE2）对斑马鱼的卵黄蛋白原（VTG）及性腺发育的影响，并通过一系列生殖发育终点指标的研究选择有效筛选环境雌激素（EEs）的敏感指标。

Objective To study the effect of ethynylestradiol ( EE_2 ) on vitellogenin ( vtg ) and gonad development of zebrafish ; to select sensitive biomarkers for screening environmental estrogens using zebrafish .

主要终点指标是客观肿瘤缓解率（ORR），次要终点指标是肿瘤缓解持续时间（DTR）、肿瘤进展时间（TTP）、肿瘤治疗失败时间（TTF）、安全性评估和毒副反应。

The primary endpoint was objective response rate ( ORR ), and the second endpoints were the durative time of remission ( DTR ), time of tumor progression ( TTP ), time of treatment failure ( TTF ), safety assessment and adverse events .

观察疗效应使用终点指标，而不是中间指标。

And use terminal index not middle index to observe curative effect .

次级终点指标包括缓解率，缓解时间和安全性。

Secondary end points included the response rate , response duration , and safety .

主要终点指标为总生存期，资料分析采用意向处理分析。

The primary endpoint was overall survival , and analysis was done by intention to treat .

最主要的观察终点指标是一年内左室射血分数和左室收缩末容积。

The primary end points were the left ventricular ejection fraction and left ventricular end-systolic volume at12 months .

依据纳入标准和排除标准筛选后剩余文献按照治疗性医学文献证据级别的判定标准进行证据分级，并按照终点指标进行证据评价。

According to the inclusion and exclusion criterion , the evidence qualities were classified by the grades of the evidence quality for the therapy articles , then we assessed the evidence by the final targets .

本文依据国内外临床试验中结局指标选择的现状，论述了替代指标与终点指标的概念及其关系，以及在临床试验中结局指标选择基本方法及其当前存在的问题。

According to the status quo of choosing outcome indexes in Chinese and other countries ' clinical trials , propose the concepts of surrogate outcomes and end points and correlation between them , discuss the general methods and present problems of choosing true endpoints .

由于试验的方法学质量普遍较低，且缺乏一些重要的终点指标和与生活质量相关的指标，目前尚不能就此得出结论，需要设计更加合理、严格执行的大样本随机试验。

However the conclusion cannot be reached yet due to the low methodological quality of the trials collecting and lacking in some important final markers and relevant criteria for quality of life , more rationally designed and strictly executed randomized trials with large samples are necessary .

本研究通过对既往单纯随机对照临床研究资料的回顾分析，通过对无法手术切除的NSCLC中医脾虚证与终点疗效指标的分析，探讨脾虚对NSCLC预后的影响；

This study investigate the relations of spleen-deficiency and NSCLC prognosis through analyzing the database of simple , randomized , controlled clinical trial ;

主要观察指标：①终点结局指标：各年龄组糖尿病发病率。

MAIN OUTCOME MEASURES : ① Final indicator at endpoint : diabetic morbidity of each age group ;

血管内皮功能障碍与诸多心血管疾病的发生、发展有密切联系，被认为是心血管疾病危险的终点替代指标。

Endothelial dysfunction is closely related to occurrence and progress of many cardiovascular diseases , and has been recognized as a surrogate end point for cardiovascular risk .

目前已广泛应用于各种慢性病和肿瘤疾病，作为一种终点评价指标，并已受到国内外学者的日益重视。

Quality of life model has been widely used in a variety of chronic diseases and neoplastic diseases , as an end-point evaluation , and has been the growing importance of the domestic and foreign scholars .

目的初步探讨急性有机磷杀虫剂中毒发生重型中间期肌无力综合征（IMS）终点的判断指标。

Objective To decide the end point of severe intermediate myasthenia syndrome ( IMS ) in the cases of acute organophosphate pesticide poisoning .

观察血压、心率、生化指标、不良反应及终点事件等指标，随访一年，分别分析效果及影响因素、成本及影响因素。

The patients were interviewed for a year to observe the pressure , heart rate , biochemical indicator , untoward effect , outcome event and so on , while the effect , cost and the influence factors were analyzed .

截至终点时观察各项指标。

The indicators were observed at the endpoint .