组织工程支架

超临界CO2技术制备组织工程支架材料初探

Pilot Study of the Preparation of Tissues Engineering Scaffold Materials by Supercritical CO_2 Fluid Technique

并对以PHB制作组织工程支架进行了初步探讨。

And PHB was made as the scaffold of the tissue engineering .

利用CT扫描资料构建基于图像分析设计组织工程支架；

Tissue-engineered scaffold materials are designed on the basis of CT scanning data and image analysis ;

基于RP的骨组织工程支架构造及生物学特性分析

Fabrication of Bone Tissue Engineering Scaffolds Based on RP and Analysis of Biological Properties

目的：探索煅烧骨（calcinedbonecalcium，CBC）作骨组织工程支架材料的可行性。

AIM : To investigate the feasibility of calcined bone calcium ( CBC ) as scaffold material in bone tissue engineering .

目的研究经聚乳酸（PLA）包埋后的不同比例PLA-聚羟基乙酸（PGA）组织工程支架对软骨细胞复合的影响及原因。

Objective To investigate the impact of different proportion of PLA embeded PLA-PGA scaffold on swine chondrocytes .

结论所制备的PVP接枝壳聚糖具有良好的生物相容性，可作为组织工程支架材料。

Conclusion The novel chitosan derivative has excellent biocompatibility and can be used as a tissue scaffold material .

提出了以聚乳酸/钙磷盐/胶原的骨组织工程支架快速成形制造的材料系统，对比了两种在聚乳酸（PLA）表面涂覆钙磷盐的工艺。

PLA / apatite / Collagen as materials system for Rapid Prototyping and manufacturing of bone tissue engineering scaffolds is presented .

目的研究仿生矿化的聚乳酸-羟基乙酸共聚物（PLGA）作为骨组织工程支架材料的可行性。

Objective To investigate the feasibility of using biomimetic mineralized PLGA as scaffold material in bone tissue engineering .

PHBV共混物纤维制备组织工程支架的研究

Study on the Tissue Engineering Scaffold Prepared by PHBV Composites Fiber

支架结构对聚乳酸组织工程支架在SBF溶液中降解进程的影响

Influence of Poly ( lactic acid ) Scaffold Structure to its Degradability in SBF

目的观察小肠粘膜下层（SIS）的生物相容性和作为组织工程支架材料的可行性。

Objective To investigate the biocompatibility and feasibility of small intestinal submucosa ( SIS ) as a scaffold for tissue engineering .

聚丙交酯&乙交酯（PLGA）共聚和物组织工程支架的实验研究甲氨蝶呤聚乳酸或聚乙交酯丙交酯纳米粒的制备及其特性

Experimental Studies on Poly ( Lactide-co-glycolide ) Copolymer Scaffolds for Tissue Engineering ; Preparation and properties of methotrexate-loaded PLA or PLGA nanoparticles

结论：成功培养全层人口腔黏膜，PLGA可作为口腔黏膜组织工程支架材料。

Conclusion : Human oral mucosa can be developed successfully with tissue-engineering methods , and PLGA can be used as scaffold for tissue-engineered oral mucosa .

结论：PLGA膜具有较好的细胞亲和性，它的表面有利于细胞的黏附，是一种较好的组织工程支架材料。

Four days later cells growed well . Conclusion : PLGA has preferable cellular affinity , which can be used as tissue engineering materials for scaffold .

结论：1.成骨细胞在CHA上增殖速度比在β-TCP上的速度快，更适宜作为骨组织工程支架材料。

CHA on osteoblast proliferation rate than in the β - TCP on fast , more suitable for bone tissue engineering scaffolds . 2 .

人工合成的HA脆性大，不能满足组织工程支架材料在力学性能方面的要求，人工提取的胶原蛋白则易引起炎症等免疫反应。

The synthetic HA is brittle , which does not meet the performance requirement of tissue engineering in the mechanical properties . The collagen extracted the animal always causes the inflammation and other immune responses .

目的：探讨珊瑚转化羟基磷灰石（CHA）作为骨组织工程支架材料的可行性，寻找最佳支架材料，为组织工程研究开辟新的途径。

Objective : To investigate the feasibility of using coralline hydroxyapatite ( CHA ) as scaffolds in bone tissue engineering and to find out the best scaffold material .

目的：探讨经改性处理后的可降解生物材料聚β-羟基丁酯（PHB）作为血管组织工程支架材料与血管平滑肌细胞的细胞相容性。

Objective To study the cellular biocompatibility of polyhydroxybutyrate ( PHB ) which acted as scaffold for vascular tissue engineering combined with vascular smooth muscle cells ( VSMCs ) .

此法制备的多孔HA具有均匀的开孔结构，孔隙相互贯通，孔径分布范围200-400μm，气孔率高达70-80%，作为组织工程支架材料具有很好的应用前景。

The porous samples prepared have an open , uniform and interconnected porous structure with a pore size of 200-400 μ m and high porosity of 70-80 % which have a great future used as bone tissue engineering scaffolds .

结论：BCP与BMSCs复合后能够有效地修复颅骨缺损，证实该材料适合作为组织工程支架材料。

Conclusion : The BCP / BMSCs composites can repair calvarial defects effectively . This / our study suggests that this material could be a promising scaffold material for bone tissue engineering .

本研究结果表明：以硫酸肝素复合胶原蛋白结合特定条件下冷冻干燥技术可以制备在组分和内部空间结构上高度仿生神经的新型神经组织工程支架材料，与Schwann细胞有良好的细胞相容性。

Heparin sulfate-collagen scaffold , produced under special freeze-drying condition , is a new kind of nervous tissue engineering scaffold , which is highly mimic natural nerve in space structure and component and has nice cellular compatibility with Schwann cells .

结论采用CO2超临界法制备的PLA-BMG多孔复合支架材料具有良好的骨诱导活性，有可能作为一种有前景的骨植入材料及骨组织工程支架材料。

Conclusion The porous PLA-BMG composite material prepared by the use of SC-CO2 has a good osteoinductive activity and can be used as a promising bone biomaterial and a bone tissue engineered scaffold .

二者具有统计学差异性（P0.05）。结论体外构建的P24/PLGA-[ASP-PEG]仿生骨基质材料是一种理想的组织工程支架材料，能诱导启动典型的软骨内化骨过程，促进骨缺损的修复。

And there was statistical difference between group A and B ( p0.05 ) . Conclusion This novel biomimetic material P24 / PLGA - [ ASP-PEG ] is an ideal scaffold for bone tissue engineering , which can trigger typical os endochondrale procession and improve repair of bone defect .

结论CPC-PLGA复合支架材料具有优良特性，适于骨组织工程支架。

Conclusion Fine performance was found in CPC-PLGA polymer and this material could be made for bone tissue engineering scaffold .

目的研究大鼠成骨细胞与Bio-oss骨粉体外复合培养对成骨细胞成骨效能的影响，探讨Bio-oss作为骨组织工程支架材料的组织相容性。

Objective To investigate the osteogenesis of osteoblasts of SD rats cultured with Bio-oss powder in vitro and study the biocompatibility of the Bio-oss powder as a scaffolds in tissue engineering with the osteoblasts .

利用溶胶凝胶生物活性玻璃粉末二次烧结工艺，制备了CaOP2O5SiO2系统溶胶凝胶生物玻璃，并以其为原料制备了用于骨修复及骨组织工程支架的块状多孔生物活性材料。

The sol gel derived bioactive glass in the system CaO P 2O 5 SiO 2 was prepared using sol gel technology and the porous bioactive material as bone defects filler and bone tissue engineering scaffold was made from the sol gel bioactive glass powder through sintering .

乌贼骨转化羟基磷灰石材料（CBHA）的制备及其作为骨组织工程支架材料的应用基础研究

The Preparation of the Cuttlebone-transformed Hydroxyapatite ( CBHA ) and the Basic Studies on Its Application as the Scaffold in Bone Tissue-engineering

目的：以多孔β-磷酸三钙（β-TCP）生物陶瓷材料作为组织工程支架，以人牙周韧带细胞（PDLCs）作为种子细胞，探索构建组织工程化牙周膜的可行性。

Objective : To investigate the possibility of generate tissue engineered periodontal ligament by using porous β - TCP as scaffold and human periodontal ligament ( PDL ) cells as seed cell .

结论采用SC-CO2法制备的PLA/BMG（7/3）多孔复合支架材料具有良好的理化性能及细胞相容性，可作为骨植入材料及骨组织工程支架进一步研究。

Conclusion The composite with PLA and BMG proportion of 7:3 possesses good physical and chemical characteristics and cellular compatibility , suggesting its potential as the bone implant biomaterial and bone-tissue engineering scaffold .