丙交酯

制备聚乳酸的中间体丙交酯（Lactide）的合成也越来越受到重视。

The synthesis of midbody lactide for the preparation of PLA is also catching more attention in this field .

产物纯度和结构分别由Thiele管和红外光谱进行测定.丙交酯粗产率达88.5%，纯产率为40.2%，表明该催化剂具有良好的催化性能。

The crude yield of lactide reaches 88.5 % and the pure yield is 40.2 % . Purity and structure of lactide are characterized by melting point and IR spectrum .

医药用聚乳酸的单体丙交酯合成及NH2-PEG改性研究

Synthesis of Lactide and Novel Medicinal NH_2-PEG-Modified Poly lactide

ε-己内酯与D，L-丙交酯ABA型嵌段共聚物合成及作为药物载体的初步评价

Synthesis and evaluation of biodegradable ABA triblock copolymer of δ - caprolactone and DL-lactide as drug release delivery

丙交酯/端羧基PLGA与壳聚糖接枝共聚材料的制备及初步评价

Preparation and in Vitro Assessment of Chitosan Grafting Lactide / PLGA-COOH Copolymers as Biomaterials

结果表明，接枝共聚物具有较短的聚L-丙交酯（PLLA）和聚乙交酯（PGA）侧链。

The results showed that the graft copolymers had short PLLA and PGA lateral chain .

可降解高分子丙交酯-乙交酯共聚物（PLGA）三维支架的细胞相容性和鼻软骨组织工程

Biodegradable Polymer Scaffold Of Poly ( lactide-co-glycolide )( PLGA ): Cytocompatibility And Nasal Cartilage Tissue Engineering In Vitro

聚丙交酯&乙交酯（PLGA）共聚和物组织工程支架的实验研究甲氨蝶呤聚乳酸或聚乙交酯丙交酯纳米粒的制备及其特性

Experimental Studies on Poly ( Lactide-co-glycolide ) Copolymer Scaffolds for Tissue Engineering ; Preparation and properties of methotrexate-loaded PLA or PLGA nanoparticles

目的探讨二性霉素B眼内缓释系统对兔实验性白色念珠菌性眼内炎的治疗作用及其安全性。方法缓释系统由二性霉素B和乙交酯丙交酯己内酯三元共聚物（PGLC）制成。

Objective To evaluate the efficacy and toxicity of sustained intravitreal amphotericin B drug delivery system ( DDS ) on experimental rabbit fungal endophthalmitis of Candida albicans .

以生物可降解乙交酯和丙交酯的无规共聚物（PLGA）为载体，将抗结核病药利福平溶解于PLGA的有机溶液中，采用通常乳化-溶剂挥发方法制备了药物缓释微球。

Microspheres containing antiphthisic drug Rifampin were prepared from poly ( lactide-co-glycolide ) ( PLGA ) as carrier by emulsion and solvent evaporation method .

本试验制备了聚乙交酯丙交酯（PLG）纳米颗粒，比较了阳离子PLG纳米颗粒和脂质体作为载体包裹CpG分子对小鼠体液和细胞免疫反应的影响。

Cationic PLG nanoparticles and cationic liposome were used as package molecules to detect the effect of CpG ODN on the cellular and humoral immune responses of mice .

聚丙交酯（PL）/丙交酯-聚乙二醇共聚物（PLEG）共混微球的制备、表征及释药行为

Preparation , Characterization and Drug Release Characteristics of Poly ( lactide )( PL ) / Poly ( lactide co polyethylene glycol )( PLEG ) Blend Microspheres

本文报道聚乙二醇（PEG）在辛酸亚锡存在下与丙交酯（LA）反应合成PEG-PLA嵌段共聚物，用~（13）cNMR测定了共聚物的结构，估算了平均链段长度。

PEG-PLA block copolymers were synthesized using polyethylene glycol ( PEG ) and lac-tide ( LA ) in the presence of low toxic stannous octoate . The copolymer structure was determined by 13C NMR and the average block leng this were calculated .

以新型稀土La-Ti复合氧化物作为催化剂，催化乳酸合成丙交酯。

A new rare earth La-Ti compound oxide catalyst to prepare lactide was employed .

目的探讨可生物降解丙交酯-乙交酯共聚物（PLGA）（80∶20）三维多孔支架生物相容性及用于构建组织工程鼻软骨可行性，为临床鼻软骨缺损的修复提供新来源。

Objective To evaluate the biocompatibility of poly ( lactide-co-glycolide )( PLGA ) foam scaffold and the feasibility of in vitro fabrication of tissue-engineered cartilage with the scaffold as an alternative approach for repairing nasal cartilage defects clinically .

结果表明这些醇铁化合物对丙交酯开环聚合都有较好的引发作用；聚合36h，单体转化率可达90%以上。

It was showed that these ferric alkoxides were efficient initiators for the ring-opening polymerization of lactides with higher than 90 % of monomer conversions polymerized at 130 ℃ for 36 h.

本课题选择了生物可降解的聚（丙交酯-乙交酯）共聚物（PLGA）作为共聚物的疏水段，选择可以避免蛋白吸附的，并被FDA批准可用于临床研究的聚乙二醇（PEG）作为亲水段。

This topic have chosen biodegradable poly ( lactic-co-glycolic acid )( PLGA ) as the hydrophobic segment of copolymer , and polyethylene glycol ( PEG ) as hydrophilic segment , which can avoid protein adsorption and approved by the FDA for clinical application .

由此认为醇铁化合物是通过配位-插入机理引发丙交酯开环聚合的，链增长的过程涉及到丙交酯酰氧键的断裂并不断插入到Fe-O键中。

It is suggested from these results that the polymerization proceeds via a coordination-insertion mechanism involving cleavage of the acyl-oxygen bond of the lactides .

以辛酸亚锡为催化剂，通过本体开环聚合合成了不同摩尔比的DL丙交酯乙交酯（DLLAGA）共聚物（PDLLGA）。

Poly ( DL-lactide-co-glycolide )( PDL-LGA ) copolymers with different DL-lactide / glycolide ( DL-LA / GA ) mole ratios were prepared by bulk ring-opening copolymerization of DL-LA with GA using tin octoate ( Sn ( Oct ) 2 ) as catalyst .

在交联剂的合成过程中，借助GPC研究了分子量与原料组成之间的关系，结果表明，交联剂的分子量可通过控制甘油和丙交酯的比例控制。

GPC was used to study the relationship between molecule weights and the radio of raw materials in the synthesization of crosslinking agents . The result showed , molecule weights of crosslinking agents would be controlled by changing the ratio of glycerol and lactide .

最后，考察了提纯后的L-丙交酯在以Sn（Oct）2为催化剂的聚合过程中，真空度、聚合温度、聚合时间以及催化剂用量对聚合产物聚L-乳酸分子量的影响。

Last , this thesis analyzes the influence of the vacuum , the reaction temperature , the reaction time and the quantity of catalyst ( Sn ( Oct ) _2 ) used on the molecular mass of polymers produced during the process of polymerization of the purified 1-lactide .

使用该催化剂，减压（50×103Pa）条件下在120～130℃下脱水2h生成乳酸低聚物。然后在150～210℃下分解低聚物，收集丙交酯，反应时间90min。

Results showed that the appropriate conditions for using this catalyst are : dehydrate at 120 ~ 130 ℃ for 2h under decreased pressure to form lactic acid oligomer and then decompose the oligomer from 150 ℃ to 210 ℃ to collect the product of lactide for 90 min.

乙酰化淀粉/DL-丙交酯接枝共聚物的合成及降解性能研究

Studies on grafting copolymerization of acetylating starch / dl-lactide and biodegradability

微波辐射法制备丙交酯的清洁工艺研究

Study on Clean Process for Preparation of Lactide by Microwave Irradiation

并对丙交酯的提纯方法进行了探讨，对产物进行了表征检验。

And then , methods of product purification were discussed .

ESO-丙交酯星形聚合物支化度的测定及其缓释性能研究

Study of Degree of Branching and Drug-Releasing Performance for ESO-Lactide Star Polymer

环氧大豆油与丙交酯星形共聚物支化度的表征

Characterization of Degree of Branching for Star-Shaped Polymer of ESO and Lactide

乳酸合成丙交酯的催化剂回收的研究

Recycling Catalyst in the Synthesis of Lactide from Lactic Acid

丙交酯的开环聚合反应在羟基上起始，淀粉是一种多羟基的高分子，其每个重复单元上含有三个羟基。

Starch is a kind of polymer with abundant hydroxyl function groups .

丙交酯中残存乳酸和水的定量测定

Quantitative Determination of Residual Lactic Acid and Water in Lactide