精神发育迟滞

脑CT检查在精神发育迟滞诊断中的应用价值

Value of brain CT in the diagnosis of mental retardation

一种新的X连锁精神发育迟滞综合征的致病基因克隆和功能分析

Identification and Characterization of the Gene Responsible for a Novel X-Linked Mental Retardation Syndrome

目的：研究精神发育迟滞（MR）学生的行为特点。

Objective : To explore the behavior characteristics of mental retarded pupils .

采用提重辨别实验对精神发育迟滞儿童（MR）和正常儿童进行了测试比较。

Twenty-eight MR children were compared with 28 normal children in a weight dis-crimination test .

X连锁非特异性精神发育迟滞相关基因功能研究进展

Progress of Functional Study on MRX Related Genes

目的探讨农村地区儿童精神发育迟滞（Mentalretardation，MR）的危险因素。

Objective To explore the risk factors of children mental retardation in the rural area .

分析58例精神发育迟滞（MR）的性犯罪和79例性受害的特征：年龄多数处于青春期，农民占50%以上，单独犯罪、累犯率和以熟人为作案对象者较多。

The authors analyzed the characteristics of 58 sexual offenders and 79 sexual victims who were suffering from mental retardation .

目的：探讨行为干预和康复治疗对儿童精神发育迟滞（MR）的疗效及预后。

Objective To study the therapeutic effect and prognosis of behaviour intervention and rehabilitation therapy on children with slow spirit growth .

目的探讨精神发育迟滞（MR）女性性自卫能力的量化评定。

Objective : To develop a rating scale , CSSD , for assessment of sexual defense ability in patient with mental retardation .

方法采用K式发育量表对51例精神发育迟滞的患儿进行综合评价；对临床资料进行统计分析；

Method 51 cases of children with mental retardation were comprehensive evaluated and their clinical materials were statistical analysed .

方法用性防卫能力检查评定量表（CSSD），对85例精神发育迟滞性被害对象进行测评。

Methods Assessments were conducted with the CSSD in85 patients with mental retardation .

结果表明：精神发育迟滞者微核出现率（4.65‰）明显高于正常对照组（2.20‰），P＜0.001。

The results showed that the micronucleus ratio of the mental retardation was much more higher than the health ( 4.65 ‰, VS 2.20 ‰, P < 0 . 001 ) .

[方法]通过回顾调查216户家庭，运用多元Logistic回归分析儿童精神发育迟滞的影响因素。

[ Method ] By retrospective investigation and multiple Logistic regression , the rick factors were analised on 216 families of mental retardation .

由此可见先天性精神发育迟滞儿童的染色体异常率较高，尤以脆性X综合征多见。

Conclusion : There was a high incidence of chromosomal abnormals in the children with congenital mental retardation , especially Fragile X Sydrome was much more common .

目的：探讨Portage计划在中国精神发育迟滞（MR）儿童干预中的适用性及其效果。

Objective : To explore the suitability and effect of Portage Early Education Program in mental retarded children .

精神发育迟滞儿童听觉事件相关电位及P300地形图研究

Study on auditory event related potentials and P300 topographic map in children with mental retardation

采用典型相关分析方法对湖南省大庸市某村75例精神发育迟滞（MR）患者和152名正常人的手部皮纹特征进行了研究。

The dermatoglyphic features of 75 cases with Mental Retardation ( MR ) and 152 persons with normal intelligence in a village of Dayong city of Hunan province were studied with canonical correlation analysis .

唐氏综合征（Downsyndrome，DS）是一种引起精神发育迟滞的最常见的常染色体遗传性疾病，由于其特殊的基因型导致了特殊的认知障碍表型。

Down syndrome ( DS ) is one of the most common genetic diseases with mental retardation . DS has characteristic cognitive impairment phenotype because of its unique genotype .

作者对50例诊断为精神发育迟滞儿童进行体感诱发电位（SEP）检查，将其结果与临床资料、EEG、智商及脑CT扫描作对照研究。

The clinical study of somatosensory evoked potentials ( SEP ) is of extensive interest . Somatosensory evoked potentials ( SEP ) were performed on 50 children with mental retardation .

Portage早期教育计划在中国精神发育迟滞儿童早期干预中的效果及适用性研究

The Adaptation and Effect of Portage Program in Chinese Children with Mental Retardation

X连锁非特异性精神发育迟滞相关基因是一类目前研究较多的基因，其突变或缺失患者仅具有一般或特殊认知功能障碍的单纯表现型。

X-linked nonspecific mental retardation ( MRX ) related genes are a group of extensively studied genes whose mutation or deletion results in simple phenotypes of generalized or specific cognitive impairment in patients , such as , low intelligence and poor social adaptability .

通过在智能发育异常儿童中筛查特殊的一类遗传性代谢病&苯内酮尿症（phenylketonuria，PKU），以了解PKU在儿童精神发育迟滞中的病因学意义。

To know its etiological significance in MR by screening a kind of particular inheritance metabolism disease called Phenylketonuria ( PKU ) in children with MR.

为了解孤独症与脆性位点的相关性，尤其是与X染色体长臂末端的脆性位点的相关性，应用细胞遗传学方法对50例孤独症、40例精神发育迟滞、17名正常人进行了脆性位点的对照研究。

To investigate the relationship between autism and the fragile sites , particularly in the distal end of the long arm of the X chromosome , 50 children with autism , 40 children with the mental retardation and 17 normal children were examined with the cytogenetics .

结论：精神发育迟滞合并精神分裂症患者的一级症状（FRS）明显减少，这有助于临床诊断与鉴别。

Conclusion The first-rank symptoms ( FRS ) in MR patients with the schizophrenic were obviously diminished , which is helpful in clinical diagnosis and identity .

为探讨轻度精神发育迟滞（MMR）刑事犯罪者的责任能力评定的决定因素，对79例MMR刑事犯罪案例的司法精神病学鉴定资料进行一项多因素分析，统计采用逐步的Logistic回归分析方法。

To investigate the relevant factors in rating the responsibilities of the criminals with mild mental retardation ( MMR ), a multiple factor analysis with the logistic regression method was carried out on the judicial expertise data of 79 cases with MMR .

结果：精神发育迟滞合并精神分裂症组与精神分裂症患者一级症状（FRS）中逻辑推理、妄想、情感平淡、思维贫乏等症状的差异具有显著性（P<0.01）。

Results There was a significant difference in the first-rank symptoms ( FRS ), delusion , flattening of effect poorness of thought between the schizophrenic patients with or without MR ( P < 0.01 ) .

本论文旨在探讨儿茶酚胺氧甲基转移酶（COMT）基因和多巴胺转运蛋白（DAT）基因的多态性与秦巴山区儿童一般认知能力及儿童精神发育迟滞（MR）的关系。

In this paper we study the catechol-O-methyltransferase ( COMT ) gene and the dopamine transporter ( DAT ) gene with the proposal to found the relationship among these genes , the children general ability ( g ) and the children mental retardation ( MR ) .

COX比例风险模型分析儿童精神发育迟滞危险因素的结果显示，父母亲智力低下或癫痫家族史、母孕期是否患慢性病、是否早产、出生后第一声啼哭是否需辅助5个因素进入最终方程。

By COX regression analysis , the results revealed 5 factors : which included the MR in parents , history of family on MR or epilepsy in parents , chronic disease in gestation period , premature birth and assisted first crying after birth entered the last regression model .

排除标准包括精神发育迟滞、器质性精神障碍、药物滥用以及受教育水平低而不能理解HCL-32问卷内容的患者。

Patients with mental retardation , organic mental disorder , drug abuse and poor education who have problem in understanding the HCL-32 were excluded .

精神发育迟滞者的刑事责任能力评定

Assessment of ability of criminal responsibility for the Mentally Retarded Persons