病毒介导基因转移

反转录病毒介导基因转移治疗脑肿瘤的安全性研究&Ⅱ.HSV-tk/ACV系统的安全性研究

Safety Assessments of Retrovirus - Mediated Gene Therapy for Glioma (ⅱ ) Safety Assessments of HSV - tk / ACV System

方法：采用反转录病毒介导的基因转移和ACV体内治疗方法进行研究。

Methods : Retroviral vector / ACV system were used .

本文还就在反转录病毒介导的基因转移过程中tk基因突变可能导致C6/NeoR+TK-细胞的出现进行了讨论。

C6 / NeoR + TK - might caused by the mutation of tk gene in the retrovirus mediated gene transfer .

腺病毒介导N-Bak基因转移对大鼠红核脊髓束的修复作用

Effects of Adenovirus N-Bak Gene Transfer on Rubrospinal Tract Injury in Rats

逆转录病毒介导的基因转移方法的建立

The retroviral - mediated gene transfer of three human cDNAs

体外实验及动物实验均表明，肝细胞对慢病毒介导的基因转移易感，表明慢病毒对肝细胞有很高的转导效率，且转入的外源基因可长期表达。

Vitro experiments and experiments conducted in animal models indicated that hepatocytes were sensitive to Lentivirus mediated transfection and the transferred gene had long-term expression . Lentivirus had high transfection efficiency to hepatocytes , and it was promising in gene therapy of transplant related disease .

腺病毒介导的BDNF基因转移治疗大鼠坐骨神经损伤

In Vivo Gene Therapy for Sciatic Nerve Injury of Adult Rats by Adenovirus-mediated Gene Transfer of BDNF

目的建立逆转录病毒介导的GM-CSF基因转移系统，为GM-CSF基因修饰的肿瘤细胞疫苗研究奠定实验基础。

Objective To provide an effective GM CSF gene transferring vector mediated by retrovirus and a basis for study of GM CSF gene modified tumor cell vaccines .

以恶性黑色素瘤细胞为主要对象，研究了逆转录病毒介导的HyTK基因转移联合应用GCV对小鼠恶性黑色素瘤细胞株B16的体外及体内杀伤作用。

The murine melanoma cell line B16 was chosen as a major target for study of the " killing " effect mediated by retroviral-HyTK / GCV system in vitro and in vivo .

重组腺病毒载体介导外源基因转移至脑血管的实验研究

Experimental study on adenovirus-mediated gene transfer to cerebral blood vessels in normal rabbit

目的探讨大鼠心脏移植过程中，重组腺病毒介导的外源基因转移至供心的可行性及安全性。

Objective To study efficiency and security of the recombinant adenoviral-mediated gene transfer to the donor heart during the heart transplantation .

逆转录病毒载体介导的标志基因转移研究

Retroviral-Mediated Reporter Gene Transfer in Human Leukemic Cells

因此，将β-珠蛋白基因导入并整合于人造血干细胞必须采用病毒载体介导的高效基因转移方法。

Therefore , the viral-mediated efficient gene transfer has to be utilized for the introduction of the P-globin gene to HSCs .