病理生理学

目前国内已开发有多种适合高等医学教育的CAI课件，但未见有适合中、高等医学职业技术教育护理专业用的将人体生理学、病理生理学合二为一的网络CAI课件体系。

At present , no CAI teaching system which combines human physiology with pathophysiology has been developed for the medical vocational education in nursing specialty at either secondary or collegiate levels .

据报道海水淹溺型肺水肿（pulmonaryedemaofseawaterdrowning，PE-SWD）是海水溺水死亡的主要原因，其主要病理生理学特点为低氧血症、高碳酸血症和代谢性酸中毒。

According to what was reported the main reason for death of sea-water drowning was pulmonary edema of sea water drowning . Hypoxemia , hypercapnia and metabolic acidosis were the common pathophysiology trait .

本文对脂肪肝的相关病理生理学、MRI的诊断及研究进展进行了综述。

This article reviews pathophysiology related to fatty liver , MRI diagnosis and their related study progress respectively .

介绍脑静脉窦闭塞的病因、发病机制及MR影像表现，并详细分析脑静脉窦闭塞后的病理生理学变化。

The aim was to analyze its pathophysiological changes and mechanism of development and differentiation of venous sinus occlusive diseases from arterial ischemic diseases .

DWI和MRS诊断缺血性脑梗死的病理生理学基础

Physiopathologic Foundation of Ischemia Cerebral Infarction Diagnosed by DWI and MRS

CHF的病理生理学表现主要在于心室重构和神经-内分泌-细胞因子系统的激活。

The main pathophysiology of CHF is the ventricular remodeling and nerve-endocrine-cytokine activation system .

病理生理学PBL教学改革的探索和实践

Practice of problem based learning in pathophysiology

探索大鼠MR脑功能成像的方法，获得急性脑静脉血栓形成的影像和组织学结果，进一步探讨急性脑静脉性血栓形成的病理生理学机制。

To explore the method of cerebral functional imaging of CVT . The results correlated MR with histological changes are got to further research pathophysiological mechanisms of acute cerebral venous thrombosis .

病理生理学PBL教学刍议

Discussion on PBL Teaching in Pathophysiology

结论心气虚证的分子基因水平的病理生理学基础与β1受体、ET和NOS基因表达有关。

Conclusion : The pathophysiological base of DHQS molecular genetics was related to β - receptor , ET and NOS genes expression .

近10a来，基于偏头痛病理生理学研究进展，相继研发了多种治疗和预防偏头痛发作的新药，对此进行综述。

This article reviews recent advances of drug therapy of migraine .

弥漫性的血管内凝血（DIC）可能是导致自发出血的病理生理学机制。

Diffuse intravascular coagulation ( DIC ) can be the underlying pathophysiological mechanism that leads to spontaneous bleeding .

目的：探讨肾素－血管紧张素系统（RAS）在多囊卵巢综合征（PCOS）的病理生理学和临床并发症中的作用。

Objective : To investigate the relationship between renin angiotensin system ( RAS ) and polycystic ovarian syndrome ( PCOS ) .

同时提示IL-13在乳腺癌病理生理学方面的潜在作用。

It also indicates a potential role for IL-13 in the pathophysiology of breast cancer .

IBS的病理生理学改变主要为胃肠道动力异常、内脏高敏感性和神经内分泌调节紊乱。

The chief change of morbid physiology is the abnormal-stomach intestine dynamia 、 the visceral hypersensitivity and the derangement of nerve-endocrine secretion .

对高EO的病理生理学作用的干预，有可能成为新的诊断和治疗方法。

The treatment of pathophysiological effects due to high level of EO might become new diagnostic and therapeutic methods .

克罗恩病（CD）与遗传、免疫、肠菌等多因素相互作用有关，近年来，随着对CD病理生理学状况了解的加深，许多有效的生物学治疗方法已经应用于CD治疗中。

Crohn disease ( CD ) is related with a complex interplay among genetic , immune and microbial factors . In recent years , many effective biological treatments have been used in CD .

结论SD大鼠脾脏指数、胸腺指数、肺泡巨噬细胞吞噬功能存在秋低春高的季节节律，这可能是秋季季节性呼吸系统多发病的病理生理学基础之一。

Conclusion There are seasonal rhythms of the functions in the spleen , thymus and alveolar macrophage in SD rats , which are lower in autumn than that in spring .

ATP敏感性钾通道（ATP-sensitivepotassiumchannels，KATPchannels）是细胞膜上偶联细胞兴奋性和能量代谢的一类重要分子，具有重要的生理学和病理生理学功能。

ATP-sensitive potassium channels ( Katp channels ) couple intracellular metabolic changes to the electrical activity of the plasma membrane , thus playing important roles in both physiological and pathological conditions .

目的：内脏高敏感性是肠易激综合征（IBS）的重要病理生理学机制之一，本文研究电压门控钠离子通道与内脏高敏感性之间的关系以进一步了解IBS的发病机制。

Objective To determine whether the voltage-gated sodium channels ( VGSC ) are involved in the visceral hypersensitivity of irritable bowel syndrome ( IBS ) .

EEG和临床特征（如强迫思维和强迫行为）的相反的关系提示强迫症两种主要症状可能有着不同病理生理学的差异。

The opposite correlations of EEG data and clinical features , i.e. obsessions and compulsions , are suggestive of pathophysiological differences based on the presence of the respective cardinal symptoms of OCD .

提示：尽管NO不参予急性肝炎患者的肝细胞损伤，但NO和TNFα却能加剧肝硬化患者的病理生理学紊乱。

These results suggest that NO does not damage the hepatocytes of the patients with hepatitis , but the TNF and NO can increase the disorder of pathophysiology of the patients with liver cirrhosis .

研究证实，高血压与炎性因子C反应蛋白及肿瘤坏死因子-α高度相关，持续的高水平C反应蛋白及肿瘤坏死因子-α可能是EH的病理生理学基础。

Study confirmed that high blood pressure has relationship with C-reactive protein and tumor necrosis factor-a , sustained high levels of inflammatory mediators C-reactive protein and tumor necrosis factor-a may be the basis for the pathophysiology of EH .

材料：实验于2004-07/12在山东大学医学院病理生理学教研室完成。选用140只雄性Wistar大鼠。

MATERIALS : The experiment was completed in the Department of Pathophysiology , Medical College of Shandong University from July 2004 to December 2004.Totally 140 male Wistar rats were involved .

观察淀粉样β蛋白1-40（Aβ1-40）对爪蟾卵母细胞表达的淋巴细胞神经递质受体（NR）功能的影响，探讨淋巴细胞NR功能检测在阿尔茨海默痴呆（AD）病理生理学上的意义。

It is designed to investigate the effects of amyloid β protein ( A β 1-40 ) on the functions of expressed lymphocyte neurotransmitter receptors ( NRs ) in Xenopus oocytes .

基质金属蛋白酶（MMP）-9与脑出血后脑水肿、炎症反应、细胞凋亡等病理生理学过程密切相关。

Matrix metalloproteinase ( MMP ) - 9 is closely correlated with the pathophysiological processes of cerebral edema , inflammatory reaction and apoptosis after intracerebral hemorrhage .

目的：观察氯沙坦对心力衰竭大鼠骨骼肌萎缩程度的影响，分析抗凋亡蛋白Bcl-2和促凋亡蛋白Bax在该影响中的作用。方法：实验于2003-04/2004-04在郑州大学病理生理学教研室完成。

AIM : To explore the influence of losartan on level of skeletal muscle atrophy in rats with heart failure , and analyze the effects of anti-apoptotic protein Bcl-2 and pro-apoptotic protein Bax .

新的临床问题重新激活对CML病理生理学机制的深入研究，从干细胞特性和骨髓造血微环境研究CML发病机制，开发新的治疗方案。

Thus , further study of pathophysiological mechanisms of CML is reactivated , focusing on the characteristics of the CML stem cell and the bone marrow niche .

实时获取RNA合成、转运、表达、定位的信息对分子生物学、病理生理学、药物的开发及疾病的诊断等研究都具有重要的推动作用。

The essential information on RNA synthesis , processing , transport , and localization obtained in real time will offer unprecedented opportunities for advancement in molecular biology , disease pathophysiology , drug discovery , and medical diagnostics .

现代病理生理学观点认为，CHF的发生主要有两大因素，即心肌重塑（心室重塑）与神经内分泌的激活。

Modern pathophysiology hold the opinion that there are two major factors related to the occurrence of CHF , namely , cardiac remodeling ( ventricular remodeling ) and neuroendocrine activation .