毒力因子

致羔羊脑炎粪肠球菌分离鉴定及毒力因子基因的PCR检测

Identification of Enterococcus faecalis Inducing Encephalitis in Lamb and Detection of virulence factor gene by PCR

目的探讨伤寒沙门菌Vi抗原作为毒力因子在致病机理中的作用。

Objective To research the role of Vi antigen of S.typhi as a virulence factor in pathogenic mechanisms of S.typhi .

Ⅲ型分泌系统（typeⅢSecretionSystem，TTSS）与动植物的许多革兰氏阴性病原菌的毒力因子的分泌有关。

Type III secretion system ( TTSS ) is associated with pathogenicity in many bacteria .

将该毒力因子的表达水平与GAS侵袭性感染严重程度相关联，有潜力发展为疾病严重程度的评判指标。

Besides , association the expression level of SsE with the invasive infection severity has the potential to develop as an evaluation indicator of disease severity . 4 .

猪链球菌2型及其毒力因子检测多重PCR的建立与应用

Multiplex PCR Assays for Simultaneous Detection of Serotypes 2 and Two Virulence Factors ( mrp / epf ) of Streptococcus suis

致病性猪链球菌2型的病原分离鉴定及毒力因子的PCR检测

Isolation and Identification on Pathogens of Swine Streptococcosis and PCR Assays for Detection of Virulence Factors of Streptococcus suis Serotype 2

大肠杆菌O（157）∶H7的分离鉴定及应用复合PCR法同时检测其三个毒力因子

Isolation and identification of E coli O _ ( 157 )∶ H_7 and simultaneous detection of its 3 toxin genes with multiplex PCR

在APP致病过程中各种毒力因子发挥着决定性的作用，且致病机理较为复杂。

Some experiments demonstrate that various kinds of virulence factors have critical roles in complicated pathogenesis of APP .

分析结果表明该双重PCR检测方法，特异性和敏感性较好，可用于快速诊断以及猪链球菌相关毒力因子的分子流行病学调查。

The results demonstrated that duplex PCR was a highly specific and sensitive diagnostic tool for the detection of virulence-associated factors of Streptococcus suis .

国内外虽然对RA有一些研究，但是在毒力因子、致病机理、保护性抗原等方面的研究尚未充分展开。

Some research has been done in RA , but little on virulence , pathogenicity and protective antigen .

安徽省114株EHECO（157）∶H7菌株毒力因子基因的初步分析

Primary Analysis of Virulent Genes of 114 Strains EHEC O_ ( 157 ) ∶ H_7 in Anhui Province

胸膜肺炎放线杆菌的毒力因子众多，各种毒力因子在APP致病过程中的角色及其相互作用的关系形成了错综复杂的网络。

The role of virulence factors and their interactions formed a complex relationships , which is very important for the pathogenesis of APP .

尽管研究者围绕GAS的毒力因子及致病机制已开展了大量研究工作，但目前对GAS导致侵袭性感染的致病机理和局部感染向侵袭性感染转化的分子机制尚不清楚。

Despite there have been a lot of researches on virulence factors and pathogenesis of GAS , the pathogenic mechanism of GAS invasive infections and the molecular mechanism how local infections transit to invasive infections are still unclear .

APP致病过程涉及众多毒力因子，目前围绕其致病机制开展了大量研究工作，然而APP早期定植感染的致病机理尚不明确。

Currently , a lot of study focuses on its pathogenesis . However , the mechanism of colonization in early infection phase is still unclear .

以上结果证明SsE不仅是GAS侵袭性感染过程中抑制中性粒细胞募集的重要因子，而且是GAS侵袭性感染过程中的重要的毒力因子。

These results demonstrate that SsE is not only the key factor required for GAS inhibition of neutrophil infiltration during invasive infections , but also an important virulence factor of GAS .

结果溶血素是一个多功能的毒力因子，对于Lm逃离吞噬细胞囊是必需的。

Results LLO is a multi-purpose virulence factor and is essential for escaping from the phagocytic vesicle of the macrophage .

本研究发现了一些潜在的李斯特菌毒力因子，为LM与LI的致病性差异研究提供了新的方向。

This study found a set of potential Listeria virulence factors , pointed out a new direction for research on the pathogenic difference between LM and LI .

以上实验结果表明，fimA是迟缓爱德华氏菌的一个重要毒力因子。

These results indicate that FimA is an important virulence factor .

本结果为寻找HPS新的毒力因子，进而研究该菌致病机制提供了理论依据。

These results provided theoretical basis for searching for the new virulence factors and studying the pathogenesis of HPS .

此外，对于LM阐明毒力因子的致病机理与免疫保护作用提供了条件。

Furthermore , it provides the possibilities to elucidate the mechanisms of pathogenesis by LM virulence factors and immune response induced . 1 .

变形链球菌的表面蛋白抗原Ⅰ/Ⅱ（AgⅠ/Ⅱ）是其重要的毒力因子，在细菌向牙面粘附的过程中发挥重要的作用。

The surface protein antigen ⅰ / ⅱ ( Ag ⅰ / ⅱ) of Streptococcus mutans is one of virulence factor , and play a key role in adhering to tooth surface .

马链球菌兽疫亚种表面的类M蛋白（M-LIKEPROTEIN）和猪链球菌2型表面的溶菌酶释放蛋白（Muramidasereleasedprotein，MRP）是重要的毒力因子和保护性抗原。

The M-like protein of Streptococcus equi subsp . zooepidemicus and muramidase released protein ( MRP ) of Streptococcus suis type 2 are important virulence factors and protective antigens .

致病性大肠杆菌的毒力因子主要有黏附素、毒素、外膜蛋白（OMP）及铁转运系统等。

Virulence factors of pathogenic Escherichia coli include adhesins , toxins , out membrane proteins , iron-sequestering system and so on .

猪链球菌2型（SS2）是重要的人畜共患病病原体，溶菌酶释放蛋白（MRP）是SS2的主要毒力因子之一。

Streptococcus suis type 2 ( SS2 ) is one of the most important zoonotic pathogens world wide .

一部分是转录激活效应器（TAL），它是一种黄单胞菌属的植物病原细菌的毒力因子。

One is the Transcription activator-like ( TAL ) effector , which is a virulence factor of plant pathogenic bacteria in the genus Xanthomonas .

由于对SS2毒力因子的了解较少限制了SS疫苗的研究及猪链球菌病的治疗与控制。

Virulence factors of SS2 are not well characterized , which inhibited the development of SS2 vaccine and cure , control the disease .

通过对其毒力因子进行鉴定，结果发现溶菌酶释放蛋白（MRP）和细胞外蛋白因子（EF）均为阳性。

PCR for virulent factor MRP ( muramidase-released protein ) and EF ( extracellular factor ) genes of Streptococcus suis type ⅱ were all positive in the 3 isolates .

结论氟微量元素矿化液比单氟矿化液具有更好的抑制致龋毒力因子GTF和LDH酶活性的作用。

Conclusion : The fluoridated remineralization solution containing trace element has stronger inhibitive effect on the enzyme activity of GTF and LDH than simply fluoridate mineral solution .

目的：使变形链球菌重要毒力因子PAc蛋白编码基因pac的遗传工程背景清晰化，以利于克隆构建DNA防龋疫苗。

Objective : To clarify the genetic engineering background of pac gene which codes PAc protein , an important virulence factor of Streptococcus mutans , so as to clone pac gene and construct anti-caries DNA vaccine .

本研究首次探讨Sec分泌途径在变形链球菌蛋白分泌过程中的作用，同时结合生物膜形成过程重点研究变链菌毒力因子分泌的变化。

In our research , we firstly discuss whether S.mutans utilizes the general secretory ( Sec ) pathway to secret virulence factors and the changes of protein secretion in the process of biofilm formation .