新生血管

目的：研究大鼠角膜新生血管的差异基因表达谱，并用原位杂交和westernblot方法对差异表达基因MMP-13的mRNA和蛋白质水平表达进行进一步证实。

Purpose : Study on differential gene expression profiles in rat CNV , by using microarrays . Hybridization in situ ( ISH ) and western blot were performed to examine MMP-13 , expressed differentially in CNV on the level of mRNA and protein .

结果：在激光诱发的大鼠脉络膜新生血管模型中，予D-Timolol腹腔注射15mg/（Kg·d），可减少荧光渗漏的位点，至对照组的83%。

· RESULTS : D-Timolol reduced the fluorescein leakage to 83 % of the control group in laser-induced rat 's CNV model at a dosage of 15mg / ( kg · d ) .

丝裂霉素C抑制实验性兔角膜新生血管形态学改变的研究

Mitomycin C Inhibiting the Morphological Changes of Experimental Rabbit 's Corneal Neovascularization

征象相比，CT征象的综合分型可以更准确地反映肿瘤内新生血管形成状况；

As compared with single CT characteristic , comprehensive types of CT features can predicate tumor neovascularization more accurately .

定量氧致SD大鼠视网膜新生血管模型的制备

A Preparation of SD Rat 's Model of Oxygen-induced Retinal Vascularization

VEGF、NO在角膜碱烧伤新生血管形成中的影响

Expressions of VEGF and NO in cornea with neovascularization after alkali burn

结果表明，丝裂霉素C结膜下注射抑制角膜新生血管的作用，可能是通过控制炎症增生和破坏新生血管内皮细胞来实现的。

C could inhibit corneal neovascularization , which was probably attributed to the controling of inflammatory proliferation and destroying of endothelial cells .

TGFβ1在乳腺癌间质新生血管周细胞中的表达

Expression of TGF β _1 in pericytes of angiogenesis in breast cancer

结论VEGF和NO均可能参与了角膜新生血管的形成过程；

Conclusion Both VEGF and NO could participate the process of corneal neovascularization .

血管生成（angiogenesis）是指从已经存在的血管床中产生新生血管系统，正常人的血管生成被严格控制在某些特定的生理过程，如生殖、发育和创口愈合等；

Angiogenesis is the formation of new blood vessels from the existing vascular bed .

环氧化酶-2和VEGF在角膜新生血管中的表达和相关性研究

The expression and correlation of cyclooxygenase-2 and VEGF in rabbit corneal neovascularization induced by alkali burn

以人MMP-2和整合素αvβ3为靶点的抑制新生血管生成的抗肿瘤药物研究

The Studies of the Anti-angiogenesis Drug Directed Against Human MMP-2 and Integrin α _v β _3

而内皮细胞生长因子（VEGF）在视网膜和脉络膜新生血管发生中起着关键作用。

Endothelial growth factor ( VEGF ) in retinal and choroidal neovascularization play a key role in the occurrence .

B组（DM组）：有2型糖尿病，未发现增生性视网膜病变及虹膜新生血管等眼部并发症住院行白内障手术的患者25例；

Group-B ( diabetic group ): 25 cases of type 2 diabetes without proliferative retinopathy and iris neovascularization selected in the same way ;

粉防己碱对大鼠角膜新生血管HIF-1α和VEGF表达的影响

Effect of tetrandrine on the expression of HIF-1 α and VEGF in corneal neovascularization of rats

实验组角膜新生血管面积在术后1周，2周，3周，1月，2月时较对照组显著减少（P＜0.01或P＜0.05）。

The area of CNV was inhibited by 1 week , 2 weeks , 3 weeks , 1 month and 2 months ( P ﹤ 0.01 or P ﹤ 0.05 ) .

结论：CD105和VEGF可作为NIP新生血管有价值的标记物，被认为是NIP的临床检测及预后判断的一个重要指标。

CD105 and VEGF are used for NIP clinic detection and prognosis .

维替泊芬光动力治疗后脉络膜新生血管膜VEGF和PEDF的表达

Expression of VEGF and PEDF in Choroidal Neovascular Membranes Following Verteporfin Photodynamic Therapy

PCNA和FⅧR：Ag在氪激光诱导大鼠脉络膜新生血管中的表达及意义

Expression and Significance of PCNA and F ⅷ R : Ag in Choroidal Neovascularization Induced by Krypton Laser in BN Rat

CD34高表达是新生血管形成活跃的表现，说明肿瘤组织的高增殖性；

The higher expression of CD34 showed active angiogenesis , indicating higher proliferation of tumor tissue .

控制VEGF表达的时间和剂量有利于形成稳定和成熟的新生血管而避免不良反应。

Controlling the timing , duration and dosage of VEGF expression could avoid deleterious effects while leading to stable and mature vessels .

抑制新生血管形成，可达到防治ROP的目的。

Angiogenesis inhibition can be achieved the purpose of combating ROP .

两组新生血管渗漏情况比较：治疗组与对照组无明显差异（P0.05）。

Comparison of two groups neovascularization leakage : No significant difference between the treatment group and the control group ( P0.05 ) . 6 .

综合分析VEGF及其受体的表达有助于对判断结直肠癌侵袭能力和新生血管形成的判断。

The comprehensive analysis of the expression of VEGF and its receptors is advantageous to estimate invasive ability and angiogenesis in colorectal cancers .

BN大鼠脉络膜新生血管动物模型的制作

CNV animal model of BN rat

视网膜新生血管形成和黄斑水肿是糖尿病视网膜病变（Diabeticretinopathy，DR）的主要临床表现，也是DR主要的致盲原因。

Retinal neovascularization and macular edema are the main clinical signs of diabetic retinopathy ( DR ), and also the causes of blindness .

血管内皮生长因子（VascularEndothelialGrowthFactor，VEGF）是被公认的作用最强的促内皮细胞生长因子，在肿瘤的新生血管形成中成为最关注的因素。

Up to date , the most potent growth factor of endothelium is vascular endothelial growth factor ( VEGF ), which plays important roles in the regulation of metastasis of malignancy .

结果大鼠角膜碱烧伤后角膜新生血管的生长过程可分为3个阶段：（1）角膜新生血管的初期阶段（烧伤后2d内）；

Results The neovascular response progresses were in three phases : ( 1 ) a latency phase preceding vessel growth (≤ 2 days after cautery );

脂质体介导endostatin基因转染抑制脉络膜新生血管的实验研究

Effects of liposome-mediated endostatin gene transfection in vivo on inhibition of experimental choroidal neovascularization in rats

结论：CD34的表达反映了HCC的新生血管化，VEGF和MVD可作为判断HCC侵袭、转移和预后的指标。

The expression of VEGF and MVD can be used as an indicator to judge the invasion , metastasis and prognosis of HCC .