手性药物

几种手性药物对映体的HPLC分离与生物样品分析

Separation and Bioanalysis of Enantiomers of Some Chiral Drugs by HPLC

应用Caco-2细胞模型研究一些手性药物和十芦丁硫酸酯吸收转运机理

Transport Mechanisms of Several Chiral Drugs and Rutin Deca ( H - ) Sulfonate Sodium in Caco-2 Cell Model

手性药物前体R（-）-扁桃酸的生物不对称合成

Study on Asymmetric Synthesis of Chiral Precursor R ( - ) - mandelic Acid Chiral Compounds

结论生物转化法在生产手性药物前体R（-）-扁桃酸中前景广泛。

[ Conclusion ] Biotransformation is a potential alternative method producing chiral precursor . R ( - ) - mandelic acid .

目的研究生物不对称催化苯乙酮酸合成手性药物前体R（-）-扁桃酸。

To study the synthesis of chiral precursor R ( - ) - mandelic acid obtained by asymmetric bioreduction of phenylglyoxylic acid .

D-（R）-甘油醛缩丙酮是近年来研究的很多的一种用来合成一些手性药物和具有光学活性的天然产物的重要前体。

D - ( R ) - Glyceraldehyde acetonide is widely used in the synthesis of some kinds of medicines and nature products .

非负矩阵因子分解算法解析手性药物重叠峰的HPLC-DAD数据

Resolution of HPLC-DAD data of chiral drugs with overlapping peaks by non-negative matrix factorization

它们是许多天然产物和手性药物的重要中间体，例如甾体，维生素E，K等。手性炔丙醇类化合物的合成方法有多种多样。

Optically active propargyl alcohols can be used in diverse areas including the synthesis of many natural products and medicines . Such as steroids , vitamin E , K , etc. The preparation of chiral propinol are variety of methods .

第二部分，手性药物PG05在浓缩过程中的稳定性分析。

Part II , Stability analysis of chiral drug PG05 in the concentration process .

综述了我研究室近年来在多肽生化和手性药物领域中的研究进展：①进行了抗癌药物AMD类似物的全新设计、化学全合成、与DNA结合活性和构效关系研究；

Recent advances in peptides and chiral drugs in my laboratory are summarized as follows : ① Studies on the design , chemical total synthesis , DNA binding characteristics and structure activity relationship of antitumor drug AMD and its analogues .

多沙唑嗪是一种抗高血压手性药物，1-（1,4-苯并二口恶烷-2-羰基）哌嗪（BCP）是合成该药物的重要手性中间体。

Doxazosin is a chiral antihypertensive drug . 1 - ( 1,4-Benzodioxane-2-carbonyl ) - piperazine ( BCP ) is an important chiral intermediate for the preparation of doxazosin .

目的：研究非负矩阵因子分解算法（NMF）用于手性药物HPLC-DAD二维数据解析的可行性及其影响因素。

Aim : To study the feasibility and influential factors for the resolution of HPLC-DAD data of chiral drugs by non-negative matrix factorization ( NMF ) algorithm .

不对称合成是手性药物制备的核心环节，Aldol反应是重要的形成C&C键的反应之一，在全合成中有广泛应用。

The Aldol reaction is an exceptionally useful strategic C & C bond-forming reaction for the stereoselective construction of cyclic and acyclic molecules . The synthetic value of the Aldol reactions has been proven by their application in the total synthesis of natural products .

微生物酶转化合成手性药物的研究进展

Advance in Synthesis of Chiral Drug by Transformation with Microbial Enzyme

毛细管电泳分离手性药物罗格列酮钠对映体的方法研究

Chiral Separation of Rosiglitazone Sodium by Aqueous / Nonaqueous Capillary Electrophoresis

分离科学是自然科学和应用科学中的一个重要分支。如今，以生物医学和手性药物分离为代表的新兴产业对分离科学提出了更高的要求。

Separation science is an essential branch of science and technology .

手性药物的两个对映体往往显示出不同的药动学和药效学性质。

Enantiomers of chiral drugs invariably have different Pharmacokinetics and pharmacodynamics .

水相体系毛细管电泳与非水体系毛细管电泳分离手性药物的比较

The comparation of nonaqueous and aqueous capillary electrophoresis in chiral separation

手性药物的结晶法拆分研究进展

Progress of Research on Crystallization Separation Methods of Chiral Compounds

手性药物与手性药物的分离分析技术

Chiral Drugs and the Technology of Chiral Separation and Analysis

使用二元环糊精体系毛细管电泳法分离手性药物

Enantiomeric Separations of Chiral Drugs with Dual Cyclodextrin Systems in Capillary Electrophoresis

高效液相色谱法拆分生物碱类手性药物对映体

Resolution of Chiral Drug Enantiomers of Alkaloids by High Performance Liquid Chromatography

手性药物联用色谱重叠峰的定性定量解析方法

Qualitative and quantitative resolution of hyphenated overlapping chromato-graphic peaks of chiral drugs

手性药物的生物活性与其立体构型密切相关。

Bioactivity of chiral drugs is closely related to the stereo structures .

超分子化学及其在手性药物识别中的应用

Supermolecular chemistry and its use in recognition of chiral drugs

毛细管区带电泳在手性药物对映体分离中的应用

Applications of capillary zone electrophoresis in separation of enantiomers in chiral drugs

酶催化的立体选择性反应在手性药物合成中的应用

Application of Stereoselective Reactions Catalyzed by Enzyme in Synthesis of Chiral Drugs

非环化糖类化合物在毛细管电泳手性药物拆分中的应用

Chiral Drugs Separation by Capillary Electrophoresis with Non-cyclic Saccharides

手性药物一叶萩碱的立体选择性代谢研究

Study on the Stereoselective Metabolism of Chiral Drug Securinine

非水毛细管电泳对9种手性药物的拆分

Nonaqueous Capillary Electrophoresis for Chiral Separation of Nine Enantiomers