手性中心

由于在分子中引入了手性中心和侧向氟原子，使得液晶呈现出不同寻常的近晶相织构。

The introduction of chiral center and lateral fluorines enable the liquid crystals to give unusual smectic textures .

富马酸比索洛尔有一个手性中心，两个对映异构体，分别为R/S构型。

Bisoprolol fumarate has one chiral center , and pairs of enantiomers , respectively for the R / S configuration .

催化剂48有一个P手性中心和一个非手性恶唑啉环。

Catalyst 48 has a P centre chirality and the oxazoline is an achiral ring .

不对称Michael加成反应是一类非常重要的反应，既可以构建碳碳键，又能够同时产生多个手性中心。

The asymmetric conjugate Michael addition is one of the most powerful bond - forming reactions to construct carbon skeletons and simultaneously generate multiple chiral centers .

主要介绍了近年来分子内Heck反应在天然产物合成中的应用，重点介绍叔碳和季碳手性中心的构筑。

Some total syntheses of natural products via intramolecular Heck reaction were reviewed focused on how to construct tertiary carbon and quartus carbon chiral centers .

提出了2型胺（氨基直接与手性中心C连接，且手性中心C上只含有一个H）在CAL批肪酶催化作用下，酰胺化的异构选择规则。

An empirical rule for amidation of Type 2 amines ( in which the amino group attaches directly to the chiral carbon and only one H atom is at it ) catalysis by lipase from candida antrarctica ( CAL ) is proposed .

含多个手性中心的麻黄碱衍生物的合成

Synthesis of derivatives of ephedrine containing multi chiral centers

该方法可以高效的构建氧化吲哚三位的季碳手性中心。

The method could efficiently construct quaternary stereocenters of oxindoles at three position .

胆甾烯基具有多个手性中心，是良好的手性向列相液晶基元。

Cholesteryl is a good chiral nematic phase mesogen because of its chirality .

它们具有三个环系和两个手性中心的结构。

They have a structure of the three ring system and two chiral centers .

同时对一些含有潜手性中心的醛也有很优秀的产率。

Furthermore , some aldehydes with prochiral center could give products in good to excellent yields .

该方法可以高效的构建三个新的手性中心，并且得到的产物可作为相应氨基酸的制备前体。

The method could efficiently construct three stereocenters and the products could be transformed into the corresponding amino acids .

糖作为一类具有多官能团、多手性中心、廉价易得的手性小分子可以很方便地作为手性助剂用于不对称合成。

Carbohydrate , with multi-functional groups and chiral centers in one small molecule , is inexpensive and can be converted into efficient chiral auxiliary for controlling asymmetric synthesis .

当芳香醛为底物时，尤其是在手性中心连有羟基配体存在下，不对称加成产物得到很高的产率和对映选择性。

High yield and enantioselectivity were received in the cases of aromatic aldehydes as substrates especially when the employed chiral ligand has a hydroxyl group attached to the chiral center .

本文以价廉易得的扁桃酸衍生物为手性中心试剂设计并合成了两个系列新型手性添加剂，确定了较为合理的反应条件。

In this paper , two series of new chiral dopants were designed and synthesized by derivative of chiral mandelic acid as a chiral reagent , which is easily obtained and low-cost .

有机金属试剂（其中包括镍、钯、铑、铁、铜）以及路易斯酸能选择性地催化氧杂双环烯烃的亲核开环反应，并建立多个手性中心。

Over the past years , several metal-catalyzed ( nickel , palladium , rhodium , ferrumiron and copper ) and Lewis acid-catalyzed ring-cleaving reactions have been developed that generate ring-opened products in high yield and enantiomeric excess .

选择性长效质子泵抑制剂泮托拉唑，主要用于治疗胃、十二指肠溃疡和反流性食管炎等胃肠道高分泌疾病，其结构中含有一手性中心硫原子，临床现在以消旋体形式给药。

Pantoprazole , a chiral benzimidazole sulfoxide derivative , is an irreversible proton pump inhibitor which is used clinically as racemate in the treatment of reflux esophagitis , Zollinger-Ellison syndrome , peptic ulcers , and other acid-related , hypersecretory gastrointestinal disorders .

作为天然的生物催化剂，酶催化化学反应具有催化效率和立体选择性高、反应条件温和的特点。酶不仅适于外消旋药物及其合成子的有效拆分，而且可用于光学活性药物手性中心的直接构建。

As natural biocatalysts , enzymes catalyze chemical reactions with high catalytic efficiency and stereoselectivity and mild conditions , which can be not only used for the efficient resolution of racemic drugs and related synthons , but also the direct construction of chiral center of optically active drugs .

手性季碳中心广泛分布于各类生物活性天然产物结构中，它的不对称催化构建是有机合成化学中的重要研究内容。

The chiral quaternary carbon centers are widely distributed in various bioactive natural products , and its catalytic asymmetric construction is an important research topic in organic synthesis .

不对称碳-碳键的合成反应，尤其是手性季碳中心的构建反应，是有机合成研究的一个重点和难点所在，对于有机合成的应用和发展具有重要意义。

Asymmetric carbon-carbon bond cross-coupling reactions , especially the construction of all-carbon quaternary stereo center , are an important part of organic synthesis and still full of challenge .

本论文针对这一课题实现了两类手性季碳中心的构筑，并应用于具有新颖结构和良好活性的天然产物全合成研究中。

Based on this point of view , two synthetic methods for constructing the chiral quaternary carbon were developed and further applied to the total synthesis of some novel structural and active natural products .

新型手性双膦配体具有多手性中心和较一般膦配体更稳定等优点。

Novel chiral phosphine ligands have multiple chiral centers and higher stability compared with other phosphine ligands .

在不对称催化氢化过程中起关键作用的是手性催化剂的结构，包括手性膦配体和中心过渡金属。

The paper reviewed the study on the chiral phosphines in asymmetric catalytic hydrogenation and their nearest development .

此外，发现中心手性起到了决定产物ee值和绝对构型的作用，平面手性和中心手性的匹配在取得高对映选择性上是重要的。

However , the match between planar chirality and central chirality is critical for high enantioselectivity .

在众多合成手性丙炔醇的方法中，端基炔对醛的不对称加成是在形成碳-碳键的同时生成一个手性二级碳中心，相较于其它方法有着显著的优势。

Among various methods to synthesize optically active propargylic alcohols , the asymmetric alkynylation of aldehydes is particularly useful because it simultaneously forms a carbon-carbon bond and a chiral secondary alcohol center in one single step .

固有手性杯芳烃是一类典型的手性大环化合物，它们的手性来自杯芳烃骨架非手性取代基的不对称排列，而非以往我们所见过的轴手性、中心手性或平面手性等分子。

Inherently chiral calix [ 4 ] arenes are a typical chiral macrocyclic compounds in which chirality generated from the asymmetric arrangement of non-chiral substituents free from a chiral axis , a center chiral or a planar chiral molecules and other chiral factors .