慢性再障

补髓生血颗粒剂对慢性再障患者临床与VLA-4/CD（49d）及相关因子影响的研究

Study on Clinic and the Effects of Marrow-Supplementing and Blood-Engendering Granule on VLA-4 / CD_ ( 49d ) and Interrelated Cytokines in CAA Patients

骨髓活检在诊断慢性再障和骨髓增生异常综合征中的价值

Bone Marrow Necrosis Evaluation of Bone Marrow Biopsy in the Diagnosis of CAA and MDS

说明IL6、IL8、Bax在慢性再障的发病机制中，可能有抑制骨髓造血和促进骨髓造血细胞凋亡的作用。

It proved that IL-6 , IL-8 and Bax can inhibit the apoptosis of hemopoietic cell of bone marrow in a certain degree .

慢性再障中单用雄激素治疗有效率76.9%，CSA和雄激素联合应用的有效率为83.3%；

In chronic AA , the rate was 83.3 % in treatment with cyclosporine A combined androgen and 76.9 % with androgen alone .

结论：慢性再障骨髓造血衰竭并非c-kit受体低表达所致；

Conclusion : CAA bone hematopoietic function failure is not due to the low expression of c-kit ;

结论：补髓生血颗粒对慢性再障患者骨髓造血细胞过度凋亡有抑制作用，下调Bax基因表达水平仅是其抑制细胞凋亡的机制之一。

Conclusion : Marrow-Supplementing and Blood-Engendering Granule can inhibit the excessive apoptosis of and Bax gene expression of hemopoietic cell of CAA patients . Inhibiting the Bax gene expression is only one of the mechanisms of inhibiting the excessive apoptosis .

慢性再障患者体内EPO、SCF、GM-CSF、IL-3分泌水平明显低于正常对照组，TNF-α、IFN-γ分泌水平明显高于正常对照组，均有非常显著性差异（P<0.01）。

GM-CSF IL-3 in chronic aplastic anemia patients was lower obviously than contrast and that of TNF - α . IFN - γ was higher markedly , all had significant difference ( P < 0.01 ) .

补肾颗粒治疗慢性再障贫血51例疗效观察

Effect of Bushen Granules on Chronic Aplastic Anemia : An Observation of 51 Cases

浅谈清热解毒法在慢性再障治疗中的应用

Application of the Heat and Toxic Materials Clearing Method in the Disease of Chronic Aplastic Anemia

10例属急性再障，4例慢性再障。

10 cases were acute aplastic anemia ( AAA ), 4 cases chronic aplastic anemia ( CAA ) .

山莨菪碱和康力龙合用对60例慢性再障的疗效与实验研究

The therapeutic effects and experimental study of anisodamine combined with stanozolol in 60 cases of chronic aplastic anemia

补肾加和解法对慢性再障患者骨髓病理学的影响

Observation on Bone Marrow 's Pathology of Chronic Aplastic Anemia Patients with Invigorate the Kidney and Mediation Method

急慢性再障发病率为（0.14／10万／年、0.6／10万／年）。

The respective incidence rate of acute and chronic aplastic anemia is 0.14 and 0.6 in 100 thousand per year .

结论：慢性再障患者存在造血调控因子介导的免疫紊乱的病理机制。

Conclusion : The disorder of immunity mechanism on hematopoiesis regulation factors was one of the pathology mechanism with chronic aplastic anemia patients .

慢性再障的治疗有效率为68.2%，重型再障为53.1%，纯红再障为77.8%。

Treatment effective rate was 68.2 % of chronic AA , 53.1 % of severe AA and 77.8 % of pure red cell aplastic anemia .

30例慢性再障病人中17例进步或治愈，11例无效或进展，无死亡病例；

17 cases of 30 cases with chronic group had got improvement or cure , 11 cases with chronic type failed , with no case died .

目的：观察补肾益髓法中药对慢性再障肾虚患者造血调控因子的调节作用，探讨不同肾虚证与造血调控因子之间的相关性及补肾中药的调节机制。

Objective : To observe how Bushen formula to regulate hematopoiesis regulation factors of chronic aplastic anemia patients , and discuss the regulation mechanism of kidney promote herbs .

将120例慢性再障患者随机分为中药组90例（其中肾阳虚组24例、肾阴虚组37例、肾阴阳两虚组29例），西药组30例。

Methods : 120 cases of chronic aplastic anemia were randomly divided into two groups , 90 cases treated with herbs ( 24 cases of kidney-Yang deficiency 37 cases of kidney - Yin deficiency 29 cases of kidney-Yin and Yang deficiency ), and 30 cases treated with chemical .

慢性和急性再障2年生存率分别为88.0%和38.2%。

The 2 year survival rate was 88 % and 38.2 % in chronic and severe AA , respectively .