头霉素
- cephamycin
![头霉素](../cache/1186505.jpg)
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头霉素C产生菌选育初筛方法的改进
A practical primary screening method of cephamycin C-producing strain breeding
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碳氮源对发酵生产头霉素C的初步研究
Preliminary study on the influence of carbon / nitrogen sources to the fermentation of cephamycin C
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目的提高棒状链霉菌的克拉维酸生产能力,去除副产物头霉素C。
Objective To improve the production of clavulanic acid and to genetically delete cephamycin C in the fermentation of Streptomyces clavuligerus .
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同时发现在发酵培养基中添加生长因子、硫源和前体可以明显提高头霉素C的产量。
Meanwhile the fermentation potency of cephamycin C was found to be increased obviously by the additions of growth factor , sulfur sources and amino acids in the fermentation medium .
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阴沟肠杆菌临床株对青霉素类、头霉素类、阿莫西林/棒酸以及一、二代头孢菌素有较高的耐药性,主要是由于AmpC酶的存在。
It is often resistant to penicillins , cefoxitin , amoxillin / clavulanic acid and first and second generation cephalosporins because of AmpC enzyme .
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结论:头霉素类抗生素可作为治疗ESBLs菌株引起的重症感染的可选药物,且对我院分离的产ESBLS大肠杆菌和肺炎克雷伯菌,头孢美唑体外活性略优于头孢西丁。
Conclusions : cephamycins can be the alternatives for ESBLs producing strains , and in vitro antimicrobial activity of Cefmetazole against Extended-Spectrum Beta-lactamases producing was higher than that of Cefoxitin in west china hospital .