头孢噻肟酸
- 网络Cefotaxime;cefotaxime acid;CTAX
![头孢噻肟酸](../cache/1186711.jpg)
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在最佳反应条件下(催化剂用量、反应物用量、结晶pH已经优化)头孢噻肟酸的合成摩尔收率超过98%。
Under the optimum conditions ( catalyst amount used , reactant amount used , crystal pH already optimized ) we got over 98 % yield in cefotaxime acid synthesis .
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在线红外检测仪在头孢噻肟酸合成中的应用
The Apply of On-line Infrared Detector in the Synthesis of Cefotaxime acid
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头孢噻肟酸合成母液回收工艺的研究
Research on process of recovery of mother-liquid in synthesis of Cefotaxime
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头孢噻肟酸合成新方法研究
A New Study on the Synthesis of Cefotaxime Acid
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部份降解的头孢噻肟酸转钠结晶工艺
Recovering Cefotaxime Sodium From Partial Degradation Cefotaxime
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方法以头孢噻肟酸为原料,采用正交试验法确定头孢噻肟成钠盐的最佳反应温度、成钠剂、有机溶媒;
METHODS The optimum reactive temperature , sodium donor , organic solvent of cefotaxime formed sodium salt in technics was confirmed by orthogonal test method with cefotaxime as raw material ;
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用头孢噻肟,头孢噻肟/克拉维酸、头孢他啶,头孢他啶/克拉维酸这两对纸片同时进行筛检超广谱β-内酰胺酶,可有效降低ESBLs漏检率。
Using both CTX , CTX / Clavulanic acid and CAZ , CAZ / Clavulanic acid simultaneously can reduce the missing rate of ESBLs .
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结论以头孢噻肟,头孢噻肟/克拉维酸这对纸片可达到有效进行CTX-M酶的表型检测的目的;
Conclusions The phenotypic confirmatory tests for CTX-M enzymes can be detected only by CTX and CTX / Clavulanic acid effectively .
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结果头孢噻肟钠收率达93%(以头孢噻肟酸计),成品质量稳定且符合中国药典2000年版二部标准规定。结论本小试工艺合理,适合于进一步扩大中试生产。
RESULTS The yield of cefotaxime sodium obtained 93 % . ( accounted with cefotaxime ), and the product quality accorded with the standard of CP edition 2000.CONCLUSION This diminutive test technics is rationalized , adapt to enlarge medium test production .
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研究了以二甲基乙酰胺(DMA)为催化剂,7-氨基头孢烷酸(7-ACA)与苯并噻唑活性酯(MEAM)为原料,一步合成头孢噻肟酸的实验过程。
The experimental process on synthesis of cefotaxime acid was studied by using 7 aminocephalosporanic acid ( 7 ACA ) and MEAM as raw material under the catalytic action of DMA .
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7-氨基头孢烷酸和2-甲氧亚氨基-2-(2-氨基-4-噻唑基)-(z)-硫代乙酸苯胼噻唑酯(AE活性酯)发生酰化反应生成头孢噻肟酸,收率90%。
Cefotaxime acid was synthesized by 7-ACA and AE active ester , the yield was 90 % .