交酯

结果表明这些醇铁化合物对丙交酯开环聚合都有较好的引发作用；聚合36h，单体转化率可达90%以上。

It was showed that these ferric alkoxides were efficient initiators for the ring-opening polymerization of lactides with higher than 90 % of monomer conversions polymerized at 130 ℃ for 36 h.

高分子量的聚丙交酯主要由丙交酯开环聚合制备。

High molecular weight PLA can be prepared by ring-opening polymerization of lactides .

载TK基因聚丙交酯乙交酯纳米粒的性质及表达研究

Study on the preparation of TK-gene nanoparticles and its expression

医药用聚乳酸的单体丙交酯合成及NH2-PEG改性研究

Synthesis of Lactide and Novel Medicinal NH_2-PEG-Modified Poly lactide

ε-己内酯与D，L-丙交酯ABA型嵌段共聚物合成及作为药物载体的初步评价

Synthesis and evaluation of biodegradable ABA triblock copolymer of δ - caprolactone and DL-lactide as drug release delivery

丙交酯/端羧基PLGA与壳聚糖接枝共聚材料的制备及初步评价

Preparation and in Vitro Assessment of Chitosan Grafting Lactide / PLGA-COOH Copolymers as Biomaterials

结果表明，接枝共聚物具有较短的聚L-丙交酯（PLLA）和聚乙交酯（PGA）侧链。

The results showed that the graft copolymers had short PLLA and PGA lateral chain .

可降解高分子丙交酯-乙交酯共聚物（PLGA）三维支架的细胞相容性和鼻软骨组织工程

Biodegradable Polymer Scaffold Of Poly ( lactide-co-glycolide )( PLGA ): Cytocompatibility And Nasal Cartilage Tissue Engineering In Vitro

聚丙交酯&乙交酯（PLGA）共聚和物组织工程支架的实验研究甲氨蝶呤聚乳酸或聚乙交酯丙交酯纳米粒的制备及其特性

Experimental Studies on Poly ( Lactide-co-glycolide ) Copolymer Scaffolds for Tissue Engineering ; Preparation and properties of methotrexate-loaded PLA or PLGA nanoparticles

目的：观察聚乙交酯（PGA）膜对预防椎板切除术后硬膜周围粘连的作用。

Objective : To investigate the effect of polyglycolic acid ( PGA ) membrane in the prevention of extradural adhesion after laminectomy .

目的探讨二性霉素B眼内缓释系统对兔实验性白色念珠菌性眼内炎的治疗作用及其安全性。方法缓释系统由二性霉素B和乙交酯丙交酯己内酯三元共聚物（PGLC）制成。

Objective To evaluate the efficacy and toxicity of sustained intravitreal amphotericin B drug delivery system ( DDS ) on experimental rabbit fungal endophthalmitis of Candida albicans .

以生物可降解乙交酯和丙交酯的无规共聚物（PLGA）为载体，将抗结核病药利福平溶解于PLGA的有机溶液中，采用通常乳化-溶剂挥发方法制备了药物缓释微球。

Microspheres containing antiphthisic drug Rifampin were prepared from poly ( lactide-co-glycolide ) ( PLGA ) as carrier by emulsion and solvent evaporation method .

制备聚乳酸的中间体丙交酯（Lactide）的合成也越来越受到重视。

The synthesis of midbody lactide for the preparation of PLA is also catching more attention in this field .

研究125I籽源持续低剂量率照射对壳聚糖涂层的聚乙丙交酯（Poly（glycolide-co-lactide），PGLA）薄层支架体外降解性能的影响。

Biodegradation properties of chitosan-coated PGLA ( poly ( lactic-glycolic acid )) brachytherapy seed - ing carrier was investigated by continuous low-dose-rate irradiation of 125I seeds in vitro .

本试验制备了聚乙交酯丙交酯（PLG）纳米颗粒，比较了阳离子PLG纳米颗粒和脂质体作为载体包裹CpG分子对小鼠体液和细胞免疫反应的影响。

Cationic PLG nanoparticles and cationic liposome were used as package molecules to detect the effect of CpG ODN on the cellular and humoral immune responses of mice .

聚丙交酯（PL）/丙交酯-聚乙二醇共聚物（PLEG）共混微球的制备、表征及释药行为

Preparation , Characterization and Drug Release Characteristics of Poly ( lactide )( PL ) / Poly ( lactide co polyethylene glycol )( PLEG ) Blend Microspheres

目的探讨复合聚乙丙交酯（PGLA）血管外支架对自体静脉修复动脉缺损的组织学变化的影响。

Objective To report the experimental observation on histologic changes of the arte rial defects repaired by femoral vein autograft with PGLA extravascular stent .

本文报道聚乙二醇（PEG）在辛酸亚锡存在下与丙交酯（LA）反应合成PEG-PLA嵌段共聚物，用~（13）cNMR测定了共聚物的结构，估算了平均链段长度。

PEG-PLA block copolymers were synthesized using polyethylene glycol ( PEG ) and lac-tide ( LA ) in the presence of low toxic stannous octoate . The copolymer structure was determined by 13C NMR and the average block leng this were calculated .

以新型稀土La-Ti复合氧化物作为催化剂，催化乳酸合成丙交酯。

A new rare earth La-Ti compound oxide catalyst to prepare lactide was employed .

目的探讨可生物降解丙交酯-乙交酯共聚物（PLGA）（80∶20）三维多孔支架生物相容性及用于构建组织工程鼻软骨可行性，为临床鼻软骨缺损的修复提供新来源。

Objective To evaluate the biocompatibility of poly ( lactide-co-glycolide )( PLGA ) foam scaffold and the feasibility of in vitro fabrication of tissue-engineered cartilage with the scaffold as an alternative approach for repairing nasal cartilage defects clinically .

本课题选择了生物可降解的聚（丙交酯-乙交酯）共聚物（PLGA）作为共聚物的疏水段，选择可以避免蛋白吸附的，并被FDA批准可用于临床研究的聚乙二醇（PEG）作为亲水段。

This topic have chosen biodegradable poly ( lactic-co-glycolic acid )( PLGA ) as the hydrophobic segment of copolymer , and polyethylene glycol ( PEG ) as hydrophilic segment , which can avoid protein adsorption and approved by the FDA for clinical application .

由此认为醇铁化合物是通过配位-插入机理引发丙交酯开环聚合的，链增长的过程涉及到丙交酯酰氧键的断裂并不断插入到Fe-O键中。

It is suggested from these results that the polymerization proceeds via a coordination-insertion mechanism involving cleavage of the acyl-oxygen bond of the lactides .

利用悬浮聚合的方法，选用甲基硅油作为体系的分散介质，乙交酯（GA）为单体，合成出了相对分子质量较高的聚乙交酯，其特性黏度[η]高达09。

Polyglycolide ( PGA ) with a relatively high molecular weight and an inherent viscosity of 0 9 was prepared by means of suspension polymerization . In this special system the methyl silicon oil was acted as a disperse medium , and the glycolide was acted as a monomer .

产物纯度和结构分别由Thiele管和红外光谱进行测定.丙交酯粗产率达88.5%，纯产率为40.2%，表明该催化剂具有良好的催化性能。

The crude yield of lactide reaches 88.5 % and the pure yield is 40.2 % . Purity and structure of lactide are characterized by melting point and IR spectrum .

以辛酸亚锡为催化剂，通过本体开环聚合合成了不同摩尔比的DL丙交酯乙交酯（DLLAGA）共聚物（PDLLGA）。

Poly ( DL-lactide-co-glycolide )( PDL-LGA ) copolymers with different DL-lactide / glycolide ( DL-LA / GA ) mole ratios were prepared by bulk ring-opening copolymerization of DL-LA with GA using tin octoate ( Sn ( Oct ) 2 ) as catalyst .

在交联剂的合成过程中，借助GPC研究了分子量与原料组成之间的关系，结果表明，交联剂的分子量可通过控制甘油和丙交酯的比例控制。

GPC was used to study the relationship between molecule weights and the radio of raw materials in the synthesization of crosslinking agents . The result showed , molecule weights of crosslinking agents would be controlled by changing the ratio of glycerol and lactide .

最后，考察了提纯后的L-丙交酯在以Sn（Oct）2为催化剂的聚合过程中，真空度、聚合温度、聚合时间以及催化剂用量对聚合产物聚L-乳酸分子量的影响。

Last , this thesis analyzes the influence of the vacuum , the reaction temperature , the reaction time and the quantity of catalyst ( Sn ( Oct ) _2 ) used on the molecular mass of polymers produced during the process of polymerization of the purified 1-lactide .

将成骨细胞复合PLGA植入裸鼠体内，硬组织切片，甲苯氨蓝染色，比较其与单纯植入成骨细胞或聚丙交酯-乙交酯（PLGA）时的异位成骨情况。

Osteoblasts were adhered to poly lactide co glycolide ( PLGA ) and then the compounds were implanted into the muscle of nude mice . The status of ectopia osteogenesis among compounds , PLGA and hOB were assayed by hard tissue section and toluidine blue staining .

可生物降解的医用高分子矫形材料聚丙交酯乙交酯（PLGA）和聚乙二醇（PEG）是FDA批准的为数不多的几个可生物降解的注射用人工合成材料，超过一定聚合度的PLGA具有疏水性。

Orthopedic Applications of Biodegradable Polymers Poly ( lactic acid ) - co-poly - ( glycolic acid )( PLGA ) and poly ( ethylene glycol )( PEG ) are the a few materials approved for inject purpose by FDA , which have hydrophobic characters in PLGA with certain molecular weight .

使用该催化剂，减压（50×103Pa）条件下在120～130℃下脱水2h生成乳酸低聚物。然后在150～210℃下分解低聚物，收集丙交酯，反应时间90min。

Results showed that the appropriate conditions for using this catalyst are : dehydrate at 120 ~ 130 ℃ for 2h under decreased pressure to form lactic acid oligomer and then decompose the oligomer from 150 ℃ to 210 ℃ to collect the product of lactide for 90 min.