长春新碱

HPLC法测定培养植物细胞中长春新碱的含量

Determining Content of Vincristine in Plant Cell Culture by HPLC

野生型p53基因促进长春新碱诱导的细胞凋亡

Wild type p53 stimulates vincristine induced apoptosis

K562及K562/VCR对长春新碱诱导凋亡的敏感性

Sensitivity to Vincristine Induced Apoptosis in K562 and K562 / VCR

而对丝裂霉素C、噻替哌、5氟尿嘧啶、长春新碱和氨甲喋呤则耐药，平均抑制率均小于30%。

There was drug resistance to mitomycin C , Thiotepa , 5-Fluorouracil , Vincristine , and Methotrexate at average inhibition rate less than 30 % .

端粒酶和核因子-kappab在胃癌细胞长春新碱耐药中的作用研究法尼酯X受体在增强胎肝细胞中对B类清道夫受体Ⅰ表达的研究

Enhancement of Telomerase and NF-Kappa B Activation in Vincristine-resistant Human Gastric Cancer Cells ; Research of FXR in increasing expression of SR-BI in hepatocyte

长春新碱对糖尿病兔肾组织整合素αv表达及胶原代谢的影响

Impact of Vincristine on the Expression of Integrin α _v and Collagen Metabolism in the Kidney Tissue of Diabetic Rabbit

TRAIL联合长春新碱对HL-60细胞生长及凋亡的影响

Effects of TRAIL plus vincristine on the growth and apoptosis of HL-60 cells

硫酸长春新碱PLGA微囊的制备及体外释放性质研究

Preparation and in vitro release characteristics of vincristine sulfate-loaded PLGA microcapsules

建立了HPLC法测定硫酸长春新碱和盐酸米托蒽醌复方脂质体的包封率。

HPLC method was established for the determination of the entrapment efficiency of the liposomes loaded with vincristine sulfate and mitoxantrone hydrochloride .

长春新碱（VCR）为重要和常用抗肿瘤药物之一。

Vincristini sulfas ( VCR ) is an important common antitumor drug .

方法：采用噻唑蓝（MTT）比色法检测长春新碱（VCR）的细胞毒性；

METHODS : The cytotoxic effect of vincristine ( VCR ) was evaluated by MTT assay .

长春新碱对小鼠肉瘤S180细胞脂质成分的影响

Effects or vincristine on Lipid Components in S180 Cells

脾动脉灌注长春新碱加栓塞治疗ITP

Study on Treatment of ITP with Vinblastine Infusion into Spleen Artery Plus Embolectomy

目的：观察不同药物对长春新碱（VCR）血管外渗的治疗作用。

Objective : To observe the effects of different medicines on VCR vascular exosmose .

IL-1β及GDNF与长春新碱引起的神经病理性疼痛有关。

The change of expression of IL-1 β and GDNF were involved in neuropathic pain evoked by vincristine .

目的探讨长春新碱（VCR）载体红细胞的体外抗肿瘤活性。

Objective To study the effect of Vincristine-loaded intact human erythrocytes on tumor cell in vitro .

这些差异表达的蛋白质和基因分子可能与胃癌细胞长春新碱耐药机制相关，为进一步研究胃癌MDR机制奠定了物质基础。

These differentially expressed proteins and genes provide materials for further investigation on the molecular mechanism of MDR .

结果①P-gp检测显示，54.5%的病例对阿霉素、丝裂霉素、长春新碱等抗生素类和生物碱类抗癌药高耐药。

RESULTS ① P-gp detection shew that 54.5 % cases express a high resistance to doxorubicin , mitomycin , vinblastine .

本文总结我院1976～1982年用环磷酰胺、长春新碱、氨甲喋呤（COM）；

During the period from 1976 ~ 1982 , 46 cases with advanced squamous carcinoma of the lung were treated with cyclophosphamide , vincristine , methotrexate ( COM ) ;

目的探讨秋水仙碱（Col）和长春新碱（Vin）诱导tk基因分子突变类型及机制。

AIM To investigate the type and mechanism of colchicine ( Col ) and vincristine ( Vin ) induced tk gene mutation .

目的研究甲氨蝶呤（methotrexate，MTX）与长春新碱（vincristine，VCR）双载红细胞体外抗肿瘤效果。

Objective : To study the in vitro anti-tumor effect of methotrexate ( MTX ) and vincristine ( VCR ) - loaded erythrocytes .

方法：采用细胞直接计数法和MTT法检测肝素对K562细胞增殖的影响，应用流式细胞术和Hoechst33342荧光染色法检测肝素对长春新碱诱导的K562细胞凋亡的影响。

Methods : Cell count and MTT assay were used to determine the effect of heparin on K562 cell proliferation . Apoptosis was evaluated by flow cytometer , Hoechst 33342 staining .

目的：研究蛋白激酶C抑制剂十字饱碱（staurosporine，ST）逆转耐长春新碱KB细胞（简称KB/VCR）的机制。

OBJECTIVE : To identify the mechanism of staurosporine ( ST ), a PKC inhibitor , in reversing the multidrug resistance in KB cell to vicristine ( KB / VCR ) .

存活生长39例（92.5%），其中32例完成了平阳霉素，卡氮芥（BCNU）、长春新碱（VCR）各浓度的药敏测定。

39 cases ( 92.5 % ) survived , and the chemosensitivity assay was done in 32 cases ( 74.4 % ) .

探讨长春新碱（VCR）对鼻咽癌CNE鄄2Z细胞增殖和周期的影响。

To investigate the impact of vincristine ( VCR ) on the cell proliferation and cycle in nasopharyngeal carcinoma cell line CNE-2Z .

目的评价有丝分裂抑制剂长春新碱和秋水仙碱的遗传毒性，并比较短期和长期tk基因突变试验的检出灵敏度。

Objective To evaluate the genotoxicity of two mitotic inhibitors vincristine and colchicine , and to compare the detecting sensitivity of tk gene mutation assay with short-and long-term treatment by them .

长春新碱（vincristine，VCR）已经应用于治疗骨肉瘤，但其具体治疗分子机制研究尚少。

Vincristine ( VCR ) has already been used in the treatment of osteosarcoma , but researches of the specific molecular mechanism of treatment was still very few .

术后用PVB（顺铂、长春新碱、博莱霉素）或BEP方案（博莱霉素、足叶乙甙、顺铂）化疗。

The adjuvant combined chemotherapy was followed , with PVB ( cisplatin , vinblastine and bleomycin ) or BEP ( bleomycin , etoposide and cisplatin ) .

方法：将不同浓度的鸦胆子油乳剂和5-氟脲嘧啶（5-Fu），丝裂霉素（MMC），长春新碱（VCR）加入体外培养的大肠癌细胞中，观察对大肠癌细胞的抑制作用。

Methods : Adding the Brucea Javanica Emulsion , 5-Fu , MMC ? VCR with different concentraction to large intestine cancer cells in vitro , and observe their inhibition to large intestine cancer cells .

研究人类白血病细胞株K562及耐长春新碱的K562变异株K562／VCR对长春新碱诱导凋亡的敏感性的差异，以探讨抗凋亡在白血病多药耐药性（MDR）中的作用。

Purpose To study the sensitivity of human leukemic cell line K562 and vincristine resistant cell variant K562 / VCR to vincristin induced apoptosis and explore the effect of antiapoptosis on the multidrug resistance of leukemia .