路易小体

病理改变以黑质致密层多巴胺神经元部分缺失、神经元中有路易小体（LewyBody，LB）形成等为特点。

The pathological changes are characterized by deficiency of dopaminergic neurons in substantia nigra compacta and formation of Lewy body ( LB ) in neurons .

帕金森病的主要特征是被称为路易小体（Lewybodies）的异常脑蛋白聚集，而a-synuclein蛋白（简称a-syn蛋白）是路易小体的主要组成部分。

Parkinson 's disease is characterized by clumps of abnormal brain proteins called Lewy bodies of which a-synuclein ( a-syn ) protein is the principal component .

应用~（18）F-DOPAPET显像诊断路易小体性痴呆

~ ( 18 ) F-DOPA PET imaging in the diagnosis of dementia with Lewy bodies

结论蛋白酶体功能障碍有可能在多巴胺能神经元的选择性死亡中起关键作用，而Parkin蛋白在路易小体的形成过程中可能起重要作用。

Conclusions Ubiquitin-proteasome system dysfunction may be the key factor involving in the selective loss of the dopaminergic neurons , and the parkin protein may contribute to the formation of the Lewy bodies .

帕金森病在病理学上的主要特征是路易小体形成和黑质多巴胺能神经元选择性丢失。

Pathologically , PD is characterized by the presence of Lewy bodies and selective loss of dopaminergic neuron in the substantia nigra pars compacta ( SNc ) .

他们报告微小逐渐的记忆力下降被发现存在纤维丛，当路易小体和中风将逐渐记忆力下降的速率加倍时。

They report that minimal gradual memory declines were seen in the absence of tangles , while Lewy bodies and strokes doubled the rate of gradual memory loss .