抗组蛋白抗体

同时对动物模型的检测显示，抗组蛋白抗体的检测可能具有早期诊断意义。

With animal model of autoimmune syndrome it waa shown that the detection of anti-histone antibody could have diagnostic value in early stage of autoimmune diseases .

目的：确定新西兰小鼠自身抗染色质抗体、抗DNA抗体、抗组蛋白抗体的遗传易感基因染色体定位。

Objective : To map the susceptibility alleles of anti-chromatin antibody , anti-DNA antibody , anti-histone antibody in SLE model - ( NZB × NZW ) F1 mice .

抗组蛋白抗体的阳性反应性比抗dsDNA抗体反应高，且出现较早。

The high level maintained at least for 4 months . The positive reactivity of antibody to total histones was greater and occurred earlier than that to ds DNA .

在34例PTU引起的ANCA阳性患者中仅1例（2·9%）抗组蛋白抗体阳性，此例患者为18例有血管炎临床表现中的1例（5·6%）。

In 34 ANCA positive patients , only one in eighteen serum samples from patients ( 5.6 % ) with clinical vasculitis was antihistone IgG antibody positive .

上述结果提示，抗组蛋白抗体和抗ENA抗体在自身免疫病的发病机理和早期诊断中，具有潜在意义，值得进一步研究。

The results suggested that autoantibody against histones or ENA was more specific for autoimmune diseases than that against DNA , and might be of significance for earlier diagnosis of the systemic autoimmune diseases , e. g. SLE , in clinic .

系统性红斑狼疮血清抗组蛋白抗体测定的初步观察

Preliminary observation on determination of antihistone antibodies in systemic lupus erythematosus

本文以间接免疫荧光法通过3项步骤制备的鼠肾底物测血清抗组蛋白抗体。

Antihistone and anti-DNA antibodies were determined by using rat kidney substrate which was prepared with indirect immunofluorescence method through three different steps .

组蛋白与某些单克隆抗体发生的交叉反应性揭示了在自身免疫性疾病中抗组蛋白自身抗体产生的可能致病原因。

The reactivity of histones with some MAbs reveals the possible pathogenesis of anti-histones antibody production in autoimmune diseases .

然后，核小体的特定亚型被抗特定组蛋白变异的抗体所分离。

Then specifc subtypes of nucleosomes are isolated with the aid of antibodies against particular histone variants .

抗核小体抗体水平、抗dsDNA抗体水平和抗组蛋白抗体水平均高于对照组。

The level of serum anti-nucleosomes antibody , anti-dsDNA antibody and anti-histone antibody were much higher than that of healthy controls .