抗原加工

天花粉蛋白通过抗原加工提呈调节T细胞免疫应答

Modulation of t - cell - mediated immune responses by trichosanthin via antigen processing and presentation

MHC-Ⅰ类抗原加工途径异常与肿瘤关系的研究进展

Research Progresss on The Relationship between Abnormal Pathway of MHC - ⅰ Antigen Processing and Tumors

非经典的HLA-DM在外源性抗原加工递呈过程中发挥重要且独特的作用。

Non-classical HLA-DM plays an important and unique role in the processing and presentation of exogenous antigens .

原发性肝细胞癌患者抗原加工转运体基因多态性、乙型肝炎病毒基因分型及相关性研究

Polymorphisms of Transporter Associated with Antigen Processing and Hepatitis B Virus Genotypes in Patients with Hepatocellular Carcinoma

抗原加工相关转运体基因多态性及夫妻共享率与妊娠期高血压疾病的相关性

Investigating the correlation between polymorphisms with couple sharing rate of TAP gene and hypertensive disorder complicating pregnancy

慢性粒细胞白血病患者树突状细胞抗原加工递呈和迁移功能观察

Investigation on antigen processing and presentation , migration ability of dendritic cells in vitro from chronic myeloid leukemia patients

树突状细胞是专职抗原加工递呈细胞，在疫苗诱导机体产生先天免疫反应和适应性免疫反应中起着至关重要的作用。

Dendritic cells ( DCs ) are the most powerful antigen presenting cells , which play an important role in innate immunity and adaptive immunity .

机体的免疫系统是一个非常复杂的生物学系统，包括补体系统、细胞因子分泌、黏附分子系统、免疫细胞的凋亡与增殖以及抗原加工递呈等诸多方面。

It is known to all that immune system is a very complex biological system , including complement system , cytokine secretion , adhesion molecule , apoptosis and proliferation of immune cells and processing and transport of antigen .

热休克蛋白（Heatshockprotein，HSP）具有分子伴侣作用，参与肿瘤抗原的加工递呈，在诱导肿瘤免疫反应中发挥重要作用。

As molecular chaperone , heat shock protein ( HSP ) participates in processing and presentation of tumor antigen and plays an important role in eliciting antitumor immunity .

肿瘤RNA转染DC可以实现完全性抗原的加工递呈，诱导强烈的肿瘤特异性CTL反应。

Tumor RNA transfection of DCs can fulfill the uptake and presentation process of total rumor antigens , and can induce potent antitumor immunity .

在外源性抗原的加工提呈途径中，抗原肽与MHCⅡ类分子的结合是激活辅助性T细胞特异性免疫应答的先决条件。

In the exogenous antigen processing and presentation pathway , peptide binding MHC class ⅱ molecule is an important prerequisite for activating helper-T-cell mediated immune response .

HSP70是一个高度保守的蛋白，其在蛋白的合成、折叠、转运以及抗原的加工递呈过程中均具有重要作用。研究表明，HSP70可作为一种分子载体，增强与其结合蛋白的抗原性。

Heat-shock protein 70 ( HSP70 ), a member of HSPs family , is a highly conserved chaperone protein involved in protein assembling , folding , transportation and antigen processing and presenting .

MHCⅡ类分子是重要的免疫调节因子，组成性表达于哺乳动物细胞表面，负责细胞外抗原的加工、呈递以活化CD4+T淋巴细胞，从而激发适应性免疫系统对外来病原体的清除。

MHC - ⅱ ( Major Histocompatibility Complex Class - ⅱ) molecules , constitutively expressed on the surface of mammalian cells , are critical immune regulators which responsible for presenting extracellular antigen to CD4 + T lymphocytes and activating the adaptive immune system to clear pathogen .

蛋白酶体与MHC-Ⅰ类抗原的加工呈递

Proteasome and processing and presentation of MHC - ⅰ restricted antigen

此复合物的形成是依赖于抗原的加工提呈途径。

The formation of the peptide-MHC complex depends on the antigen processing and presentation pathway .

在内源性抗原的加工提呈途径中，真核细胞中的泛素&蛋白酶体系统对内源性抗原蛋白发挥着重要的降解功能。

The ubiquitin-proteasome system of the eukaryote plays an importance role in the process of endogenous antigen degradation .

特别是可以模拟内源性抗原的加工呈递过程，诱发特异性细胞免疫反应。其免疫途径有肌肉注射、皮下注射、静脉注射等。

It also can mimic the processing and presenting of endogenous antigen , thus inducing T cell response .

因此，抗原的加工提呈过程对T细胞表位的产生起到决定性作用。

Therefore , in the process of producting T cell epitope , the antigen processing and presentation pathway plays a key role .

结论：不同系的BXD小鼠，其DC的抗原提呈、加工能力不同。

Conclusions : Processing and presenting of tumor Ag of Dendritic cells is variable and BXD strain dependent .

未成熟期树突状细胞可由粘附分子选择素介导进入炎症组织，并具有极强的抗原内吞和加工处理能力，但其激活初始T细胞的能力较弱。

Mediated by adhesion molecule , the DC enters inflammation tissue with the potent ability of antigen endocytosis and treatment , but it is endowed with the weak ability to stimulate naive T cells .

该抗原经抗原递呈细胞加工后能被HLAI类或II类分子递呈，引起针对MAGE-A3表达阳性的肿瘤细胞的特异性免疫。

MAGE-A3 can be presented by both HLA class I and HLA class II molecules after being processed into antigen peptide .

树突状细胞（Dendriticcells，DC）是已知的功能最强的专职抗原提呈细胞，在抗原加工提呈、抗原识别及T细胞激活中发挥重要作用。

Dendritic cells ( DC ) is the most potent antigen present cells ( APC ) . It plays an important role in antigen recognition , antigen processing presenting , and T cell activation .

乙型肝炎病毒表面抗原-抗体复合物对抗原的加工递呈与诱生细胞因子的作用

Effects of HBsAg-Anti-HBs complex on antigen processing , presentation and induction of cytokines

树突状细胞（Dendriticcells，DCs）是机体重要的抗原呈递细胞，可将肿瘤性抗原加工、呈递给自然杀伤细胞和细胞毒T细胞，对肿瘤起杀伤作用。

Dendritic cells is the important antigen presentation cells in body which can present tumor antigen to nature killed cells and cytotoxic cells , so can exercise the function of killing tumor .

免疫应答的产生首先由抗原提呈细胞（antigen-presentingcell，APC）摄取抗原，经其加工、处理后将信息传递给淋巴细胞，引发一系列特异性免疫应答。

The first step of immune response is antigen-presenting cell ( APC ) intape antigens .

免疫反应的发生首先是由抗原提呈细胞（Antigen-presentingcells，APC）捕获抗原，经其加工、处理将抗原信息提呈给T、B淋巴细胞，从而启动一系列的特异性免疫应答。

The induction of antitumor immunity is a multi-step process , which includes the capture and processing of tumor antigen by antigen presenting cells ( APC ), selection and activation of antigen-specific T cells , then recognition and attacking of effector lymphocytes to the tumor cells .