蛋白质类药物

基于脂质体技术的蛋白质类药物传递系统的研究

Study on Protein Drug Delivery System Based on Liposomes Technology

纳米粒作为肽类和蛋白质类药物的载体

Nanoparticles for Peptide and Protein Drug Delivery

coli中的表达来获得蛋白质类药物，已经成为生产基因工程药物的重要手段，然而重组蛋白质在E。

Coli have been one of important methods to produce genetic engineering pharmaceuticals , but the recombinant proteins are accumulated as inclusion bodies in E. coli .

多肽、蛋白质类药物的口服给药途径因生物利用度低而受到限制，原因在于这类药物易受胃肠道内pH环境和蛋白酶的影响而失活。

Oral route of peptide or protein drugs is restricted due to its low bioavailability . The main reason is that such drugs are susceptible to the pH environment in the gastrointestinal tract and protease inactivation .

受体内pH和酶的降解作用影响，多肽与蛋白质类药物主要通过注射途径给药，寻求该类药物非注射途径给药方法，一直是药剂学研究的热点。

Injection is the main strategy for administration of peptide or protein because of its instability under the effect of pH and enzyme . So the studies on the approaches of non-injection administration have been interesting and significant .

重组人促红细胞生成素（rhEPO）主要通过中国仓鼠卵巢细胞系生产。rhEPO不仅是一种具有很高经济效益的蛋白质类药物，也可以作为兴奋剂使用。

Recombinant human erythropoietin ( rhEPO ), generally produced in Chinese hamster ovary ( CHO ) cells , can be used as not only a therapeutic protein but also a doping agent in sports .

结晶化蛋白质类药物传递系统的研究进展

Progress in the development of crystallized proteins as drug delivery system

多肽蛋白质类药物离子导入经皮给药的研究进展

Advances in iontophoretic transdermal delivery of peptide and protein drugs

多肽与蛋白质类药物给药系统的研究现状

Recent developments in DDS study of peptides and proteins

圆二色谱可用于蛋白质类药物的质量控制。

CD can be applied to the quality control of bio - pharmaceutics .

多肽、蛋白质类药物微囊化的两种新型实用设备

Two Novel Instruments Used in Peptide and Protein Microencapsulation

蛋白质类药物合成方法学研究进展

Progress in Synthetic Methodology for Protein Drugs

除蛋白质类药物外，胞饮在药物转运过程作用不大。

Pinocytosis probably plays a minor role in drug transport , except for protein drugs .

方法综述了多肽、蛋白质类药物的性质特点和影响其稳定性的原因；

METHOD Review the characteristics of polypeptide and protein drugs and the causes of their instability ;

并且，其与蛋白质类药物、基因、甚至细胞的相容性差，限制了在临床中的应用。

Moreover , their poor compatibility with protein drugs , even with cells , greatly hampered their clinical applications .

目的介绍肽类和蛋白质类药物肺部给药的体内外评价方法。

OBJECTIVE To introduce the in vivo and in vitro evaluation methods of pulmonary delivery of proteins and peptides .

基因治疗是二十世纪九十年代以后才逐渐发展起来的一种全新的治疗手段，与传统的利用蛋白质类药物不同，它是将外源性核酸等遗传物质导入人体。

Gene therapy is a promising method to treat disease , which has been developed since the last decade of the twenty-century .

近年来，多肽和蛋白质类药物的缓释或控释给药系统发展很快，尤其倾向于使用以生物可降解材料为载体制备毫微球或微球长效注射剂。

In recent years , protein drugs delivery systems have been developed fast , especially for long-acting injectable microsphere made with biodegradable biomaterials .

介绍双喷嘴喷雾干燥和超声雾化-低温萃取两种多肽、蛋白质类药物微囊化的新型设备，分别举例阐明两者的工作原理。

Two novel instruments for double nozzle spray drying and cryogenic process , used in microencapsulation of peptides and proteins were introduced and their operating principles were exemplified respectively .

一些农用化学品公司，包括拜耳和先正达，一直在寻找方法使复杂的蛋白质类药物在植物中表达，虽然进展是缓慢的。

A number of agrochemical companies , including Bayer and Syngenta , have been looking at ways to make complex protein drugs in plants , although progress has been slow .

凝胶过滤色谱因其操作方法简单、重复性强等特点在大分子的分离纯化中被广泛使用，特别在基因工程蛋白质类药物的精细纯化中起着难以替代的作用。

Gel filtration chromatography has occupied a key position in the purification of macromolecules for its simplicity and high reproducibility , especially in the polishing purification step of gene engineering protein drugs .

结论肽类和蛋白质类药物肺部给药的体内外评价方法与其他给药途径有较大区别，在研究和开发中应根据需要选取适当的方法。

CONCLUSION In vivo and in vitro evaluation of pulmonary delivery of proteins and peptides are different from the one in other administration route . It 's necessary to choose appropriate method in research and development .

在药物控释体系中，大多数的多肽、蛋白质类药物都是水溶性的，而作为包埋材料的生物可降解高分子则是油溶性的，这给载药微囊的制备造成了很大的困难。

In the drug delivery system , a majority of polypeptides and protein drugs are water-soluble , but the biodegradable polymers , as the carrier material , are oil-soluble , it is very difficult for the preparation of drug-loaded microcapsules .

生物活性肽是现今研究的热点活性物质之一，具有多种生理活性，而且与其它蛋白质类药物相比，它被机体吸收的效率更高，因此受到越来越多的关注。

Bioactive peptide is one of the most popular active substances in current study , which has a variety of biological activities . Moreover , bioactive peptides , compared with other proteinic drugs , can be absorbed by the human body more efficiently and therefore gain more and more attention .

蛋白质多肽类药物非注射制剂研究现状

Current research status on the non-parenteral preparations of protein and peptide drugs

胶体给药在蛋白质多肽类药物中的应用

The application of colloidal drug delivery systems in protein and peptide drugs

生物制药：电化学生物传感器可用于生物制药，原理是采用DNA重组技术或其他生物技术来研制的蛋白质或核酸类药物。

Electrochemical biosensors are used in biological pharmacy . The mechanism : medicine of protein and nucleic acid , which are produced by DNA recomposing technology and other biological techniques , is used .

结论蛋白质及多肽类药物的肺部给药系统具有广阔的应用前景。

CONCLUSION Pulmonary delivery for protein and peptide drugs has grand prospect .

提高蛋白质和多肽类药物代谢稳定性的研究进展

Progress in the Stability of Protein and Polypeptide Drugs

蛋白质、多肽类药物控制释放体系的研究

Studies on Controlled Drug Release of Protein and Peptides