疾病动物模型

疾病动物模型对医学发展做出了很大贡献。

Disease animal model has made big contribution to the medicine development .

对皮肤疾病动物模型的哲学思考

Philosophical thoughts on the skin disease animal model

结论ENU为小鼠的强诱突变剂；通过诱变可以得到遗传突变小鼠，为建立人类疾病动物模型提供条件；

Conclusion The mouse models for human diseases could be obtained by ENU-induced mutation .

因此建立一种稳定的大鼠胚胎干细胞（rES）分化体系对于分析rES早期发育、基因功能以及应用于基因打靶制作人类疾病动物模型非常必要。

So establishing a stable rat embryonic stem cells ( rES ) differentiation system is necessary for analysis of early development and gene function of rES , and production of animal models for human disease by gene targeting .

但通过疾病动物模型得到的实验结果却不尽相同：有些结果显示PAR-2激活引起呼吸道的过敏性炎症反应，有些则发现PAR-2的激活在过敏性疾病中起到保护作用。

However , some controversial effects of PARs were observed from the experimental study with animal model . Some studies showed that activation of PAR-2 induced the allergic inflammatory response , while others demonstrated the protective role of PAR-2 activation in allergic disease .

自身免疫性疾病动物模型&佐剂性关节炎的制备

Adjuvant Arthritis as an Animal Model of Autoimmune Disease

而疾病动物模型建立的主要原则就是病因诱导原则。

The primary principle of establishing animal disease model is etiology-based induction principle .

转基因疾病动物模型，通过不表达或过量表达的基因来表现各种疾病。

Through the gene expression and overexpression , transgenic animal models were established .

疾病动物模型研究和精子载体法的转基因技术

Animal Disease Models and the Sperm-Mediated Gene Transfer Technique

PET/CT影像技术在神经退行性疾病动物模型研究中的应用

Application of PET / CT on the Research of Neurodegenerative Disease Animal Models

转基因疾病动物模型的研究进展

Advance in Animal Models of Transgenic Diseases

从而使得小鼠成为人类疾病动物模型的首选。

It makes mouse the model organism of choice by academic and industrial researchers to study human diseases .

人为建立遗传易感性的疾病动物模型，首先要实现对基因的操作。

To establish genetic susceptible animal disease model , we first need to be able to manipulate genes in vitro .

本文就基因打靶技术及其在人类疾病动物模型研究中的应用做一介绍。

Gene targeting technology and its application in research of animal model of human disease were briefed in this paper .

这种治疗方法已经在造血干细胞移植、器官移植以及自身免疫性疾病动物模型中得以证实。

This approach has been proven successful in animal models of hematopoietic stem cell transplantation , solid organ transplantation and autoimmunity .

随着生物医学的发展，通过研究疾病动物模型的生物学指标有可能分析得出该疾病动物模型的证候特性。

Following the development of biomedicine , it is possible to analyze the syndrome characteristics of animal disease model by biological parameters .

目的观察应用胫骨横向骨搬移法对犬下肢缺血性疾病动物模型的血管再生效果。

Objective To study the effect of transverse tibial bone transport method on stimulating revascularization in a dog hind limb ischemic model .

现代与传统方法的结合是今后建立疾病动物模型的大趋势。

In a word , the combination of the modem and traditional techniques is the main trend to the future work of animal model establishment .

猪在人类疾病动物模型、新药安全性有效性评价、异种器官移植供体等领域均显示出独特优势。

Pigs show unique advantages in the aspects of animal models about human diseases , the effectiveness and security evaluation of new drugs and the donation of xenotransplantation .

简要介绍了应用裸小鼠以来建立的各种皮肤疾病动物模型及裸小鼠在皮肤毒理学上的应用，并展望了裸小鼠在皮肤病学和皮肤毒理学应用中的前景。

In this paper , animal model of dermatosis based on nude mice and the use of nude mice in dermatotoxicology are described and the prospective development is also discussed .

基因打靶在基因功能研究、家畜遗传改良、人类疾病动物模型的建立和基因治疗等方面有着广阔的应用前景。

Gene targeting has been widely used in the fields of gene function research , the inheritance and improvement of livestock , construction of the diseasel animal models and gene therapy .

以往的非基因时代，传统的以自发性和诱发性方法建立的疾病动物模型，在人类对疾病的研究探索中起到了重要的作用。

Traditionally , the establishment of animal disease models is either spontaneous or inductive , which played a key role in the exploring research of human diseases during the non-gene era .

人类疾病动物模型（animalmodelsofhumandiseases）是为阐明人类疾病的发生机制或建立治疗方法而制作的、具有人类疾病模拟表现的实验动物。

The animal model of human disease is made for expounding the occurring mechanism of human disease or the establishment of treatment method , which has the experimental animal which human disease simulates the performance .

目前已经建立了几种较理想的诱导表达系统，它们是研究新基因功能、构建人类疾病动物模型、寻找新的有效药物的有力工具。

Up to date , several inducible expression systems have been established and become the potent tools for studying the function of genes of interest , developing animal models of human diseases , and targeting novel effective drugs .

具备高灵敏度、较低价格及操作简单等特点的光学分子影像技术及日益成熟的人类疾病动物模型技术则为分子影像学迈进试验与预临床阶段奠定基础。

Optical molecular imaging technology with features of a high sensitivity , low price and simplified operation , and the fast maturity of animal models of human disease laid the foundation for molecular imaging technology into the test and pre-clinical stages .

缺血性脑血管病极大地危害着人类健康，而相关疾病动物模型的研究在脑卒中的防治中具有重要作用，因此受到广泛的重视。

The ischemia of cerebrovascular disease is greatly endangering mankind 's health , but the significant action in the prevention and cure that correlation disease animal model is researched at the brain palsy , hence being subjected to the wide-ranging high opinion .

转基因技术为人类疾病动物模型研究提供了一种新的方法，本文就神经系统疾病、肿瘤、心血管疾病、皮肤病、传染病等领域的转基因动物模型研究简要概述。

Transgenic technology has been a new method for research of animal models of human diseases . This article is a review on the development of transgenic animal models of human diseases such as neural diseases , tumors , cardiovascular diseases , dermatoses , infections , etc.

小鼠因其独特的生理和遗传特性，已成为生命科学领域中进行基因功能研究、发育生物学研究、疾病动物模型等最理想的模式动物。

Because of the unique physiological and genetic characteristics of the mouse , it has become the best suitable animal model in the field of life science for the research of gene function , developmental biology , and construction of animal disease models and so on .

研究者们试图用ES细胞建立糖尿病、老年型痴呆、帕金森氏症等遗传疾病转基因动物模型。

With the help of ES cells , scientists are trying to set up the cell and animal models of diseases such as diabetes , Alzheimer 's disease and Parkinson 's disease , produce the transgenic animals .

在多种急慢性炎症疼痛疾病和动物模型中，炎症局部或中枢的COX-2蛋白和mRNA显著表达，说明COX-2在急慢性炎症疼痛中的诱导作用。

In many acute and chronic inflammatory pain s in patients and animal models , Cox-2 protein and mRNA are strongly expressed in inflammatory sites and central nerve system , which suggests the inducible action of COX-2 in inflammatory pain .