洛伐他汀

组为阳性对照组，在B组基础上每日口服洛伐他汀；

C group was positive control group , which was orally administrated Lovastatin per day on base of B group ;

HPLC测定洛伐他汀烟酸缓释片中两组分含量

Determination of two components in lovastatin and niacin sustained release tablets by HPLC

结论在进行烟酸/洛伐他汀复方缓释整体剂量滴定法的II期临床试验中，控制其病例脱落率较为重要。

Conclusion It is imported that the deciduous rate in the clinical trial phase II was controlled .

Monascusruber5031洛伐他汀合成酶基因的PCR分析

PCR analyses of Monascus ruber 5031 monacolin K biosynthetic gene cluster

结论UV可用于洛伐他汀缓释片的质量控制和释放度研究。

Conclusion The UV method can be used in the quality control of lovastatin sustained-release tablets .

红曲有效成分洛伐他汀对高脂小鼠血脂代谢及脂蛋白脂酶mRNA表达的作用

Effect of Lovastatin from Red Kojic on lipid metabolism and expression of lipoprotein lipase mRNA in hyperlipidemic mice

目的探索采用反相高效液相色谱法（HPLC），提高检出血浆洛伐他汀浓度及缩短测定时间。

Objective To improve the detection concentration and time of plasma lovastatin by studying the RP-HPLC method .

RP-HPLC测定洛伐他汀及片剂的有关物质

RP-HPLC Determination of the Related Substances of Lovastatin and Its Tablets

目的：研究po洛伐他汀胶囊与美降之片后，洛伐他汀在血浆中的药动学与相对生物利用度。

OBJECTIVE : To study the pharmacokinetics and relative bioavailability of lovastatin capsule .

RP-HPLC法测定洛伐他汀胶囊及片剂的含量

Determination of Lovastatin in Capsules and Tablets by RP-HPLC

RP-HPLC测定洛伐他汀及胶囊的含量

Determination of Lovastatin and Lovastatin capsules by RP-HPLC

洛伐他汀对HL-60、KG-1、K562白血病细胞体外作用的研究

Effects of Lovastatin on Leukemia Cells HL-60 , KG-1 , K562 in Vitro

方法：临床研究：40例高脂血症患者随机分为2个组，A组（血脂康组），B组（洛伐他汀组）。

Methods : Clinical effect : 40 cases of hyperlipemia patients were divided randomly into 2 groups : Group A ( XZK group ), Group B ( Lovastatin group ) .

目的分析Monascusruber5031洛伐他汀合成酶基因的结构。

Objective Analyses the structure of Monascus ruber 5031 lovastatin biosynthesis gene cluster .

洛伐他汀和地塞米松对成骨细胞凋亡及Caspase-3活性影响的实验研究

Empirical Study of the Influence of Lovastatin and Dexamethasone on Apoptosis and Activity of Caspase-3 of Osteoblasts

洛伐他汀促进成骨细胞增殖、BMP-2表达和矿化的实验研究

Experimental study on lovastatin promoting proliferation , bmp-2 expression and mineralization of osteoblasts

洛伐他汀对MCF-7细胞pRb蛋白表达及增殖功能的影响

Effects of Lovastatin on Proliferation Ability and pRb Protein Expression of MCF-7 Cells

洛伐他汀低剂量（2mg／kg）与高剂量（4mg／kg）处理组；

Low dose ( 2mg / kg ) and high dose ( 4mg / kg ) of lovastatin-treated group ;

洛伐他汀对高糖诱导大鼠近端肾小管上皮细胞钠钾ATP酶活性的影响

Effects of Lovastatin on Na + , K + - ATPase activity of rat proximal tubule epithelial cells under high concentration of glucose

洛伐他汀对MCF-7细胞核转录因子和细胞周期调控蛋白表达的影响

Effect of lovastatin on the expression of I κ B α and cell-cycle regulating protein in MCF-7 cells

各剂量PSK和洛伐他汀均不能显著降低实验性高脂血症家兔血浆TG水平（P>0.05）。

Neither high dose PSK or lovastatin could recover plasma TC and LDL levels of experimental hyperlipoidemia rabbits to normal .

目的：研究洛伐他汀缓释片在Beagle犬体内的药动学特征及其口服相对生物利用度。

AIM : To study the oral correlative bioequivalence and pharmacokinetics of lovastatin sustained release tablets in Beagle dogs .

其开环率不低于90%，水相中开环洛伐他汀HPLC含量达到92%。

Under this condition , the percentage of cleaved Lovastatin was more than 90 . Moreover , the content of open-ring Lovastatin in water phase was 92 % detected by HPLC .

洛伐他汀对人乳腺癌细胞MDA-MB-231的生长抑制作用及相关机制

Effects of lovastatin on proliferation of human breast cancer cell MDA-MB-231 and its Mechanisms

洛伐他汀与Omega-3脂肪酸对老年混合型高脂血症患者的影响

The efficacy of lovastatin and omega-3 fatty acid in treatment of combined hyperlipidemia in old people

洛伐他汀对糖尿病大鼠肾功能及肾脏组织p38丝裂原激活蛋白激酶表达的影响

Effects of lovastatin on renal function and expression of phosphorylating - p38 mitogen-activated protein kinase in experimental diabetic nephropathy in rats

上述结果提示：HMG-CoA还原酶抑制剂洛伐他汀抑制HL-60细胞内源性胆固醇合成后，能显著抑制细胞增殖，诱导细胞凋亡。

These observations suggest that : lovastatin could inhibit the cellular proliferation and induce apoptosis significantly in HL-60 cells .

辛伐他汀、洛伐他汀或阿伐他汀降低血清TC、LDLc以及TG的幅度分别与治疗前相应的基础血脂水平呈正相关。

A positive linear correlation was found between baseline values and effects of simvastatin , lovastatin , or atorvastatin in reducing serum TC , LDL C , and TG , respectively .

GGPP能明显逆转洛伐他汀对ADPKD囊肿衬里上皮细胞和间质成纤维细胞I型和W型胶原分泌的抑制作用（尸<0.01）。

GGPP was able to reverse the growth inhibition of lovastatin in ADPKD cyst-lining epithelial cells and fibroblasts .

结果洛伐他汀治疗后血TC、LDL-C浓度明显降低，HDL-C浓度升高，差别有非常显著意义（P<0.01），TG则下降不明显（P>0.05）；

Results The level of plasma TC and LDL-C decreased obviously and the level of HDL-C was elevated after treatment by Lovastatin ( P < 0.01 ) .