洛美沙星

盐酸洛美沙星及其胶囊的HPLC测定

HPLC determination of Lomefloxacin and its capsules

目的建立RP-HPLC法测定盐酸洛美沙星及其制剂的含量。

OBJECTIVE RP-HPLC method was established to determine the Lomefloxacin and its preparations .

方法采用HPLC法测定血浆中洛美沙星浓度。

Methods The plasma concentration was determined by the HPLC technique .

HPLC柱切换法测定人血浆及尿中洛美沙星浓度

Determination of lomefloxacin in human plasma and urine by HPLC column switching technique

实验结果表明，铜（Ⅱ）和DNA均能与洛美沙星作用而猝灭洛美沙星分子的内源性荧光。

The results show that the fluorescence intensity of LMX can be quenched in the presence of Cu (ⅱ) or DNA in LMX system .

目的：建立洛美沙星人血浆及尿药浓度HPLC柱切换测定法。

OBJECTIVE : To establish a simple HPLC column switching method for measuring lomefloxacin in human plasma and urine .

RP-HPLC法测定天门冬氨酸洛美沙星注射液的含量

Determination of lomefloxacin aspartate injection by RP-HPLC

洛美沙星（Lomefloxacin）透皮吸收搽剂中氮酮的最佳浓度

Determination of the Best Concentration of Azone in the Lomefloxacin Liniment of Transdermal Absorbent Preparation

方法将86例下呼吸道细菌性感染患者随机分为A、B组，B组给予洛美沙星注射液连续静脉滴注治疗；

METHODS : 86 patients with lower respiratory tract infections were randomly divided into Group A and Group B. lomefloxacin was given by continuous intravenous infusion in Group B , while it was given by sequential therapy in Group A.

采用紫外分光光度法（λ（max）287±1nm）对国产及日本产盐酸洛美沙星胶囊进行体外溶出度测定。

The dissolution of domestic and Japan Lomefloxacin capsules was determined by UV spectrophotometry (λ max 287 ± 1nm ) .

据此利用荧光和紫外光谱研究了洛美沙星和氧氟沙星共存时与BSA的作用来探讨两种药物之间的相互作用。

To investigate the interaction between LOM and OFL , the coexistent LOM and OFL binding to BSA were studied using fluorescence and ultraviolet spectroscopy under imitated physiological conditions .

结果：盐酸洛美沙星葡萄糖注射液对鲎试剂的凝集反应有干扰作用，调节药液pH值至68～72可消除干扰，用灵敏度为025EU/ml的鲎试剂可进行细菌内毒素检查。

RESULTS : Lomefloxacin and glucose injection could interfere with limulus test , however , the interference could be eliminated after adjusting the pH of injection to 6.8 ~ 7.0.The proper concentration of limulus test agent of bacterial endotoxin test was 0.25EU/ml .

洛美沙星和阿莫西林多克隆抗体的制备及Ci-ELISA检测方法的初步研究

Preparation of Multi-clonal Antibody and Development of Ci-ELISA Again Lomefloxacin and Amoxicillin

目的测定盐酸洛美沙星（lomefloxacin，LMLX）局部用药后兔眼组织的浓度。

Objective To measure the rabbit ocular tissue concentration of lomefloxacin ( LMLX ) after its topical application .

方法使用HPLC分离分析技术确定盐酸洛美沙星水溶液在不同pH值缓冲溶液、不同离子强度不同离子条件下水溶液、不同介电常数溶液中经光照处理的光降解动力学参数。

METHODS The HPLC method was used to determine the photodegradation kinetic parameters of lomefloxacin hydrochloride aqueous solution ( 10 μ g · mL - 1 ) under various pH buffer solutions , various ionic strength of different ions and various dielectric constant conditions .

含氮杂环药物洛美沙星和氧氟沙星对BSA的荧光均具有较强的猝灭能力，两种药物共存的情况下，荧光猝灭效果更强。

Nitrogened heterocyclic drugs lomefloxacin ( LOM ) and ofloxacin ( OFL ) have a powerful ability to quench the fluorescence of BSA . The fluorescence quenching action is much stronger when two drugs coexist .

A1、A2、A5、C1、C4、D1、D2等具有较好的抗G~-菌活性，相当或略优于洛美沙星和帕苏沙星。

The activities of Al , A2 , A5 , Cl , C4 , Dl and D2 against Gram-negative organisms were equivalent to or slightly more potent than those of lomefloxacin and pazufloxacin .

研究水杨酸（APC）和洛美沙星（LFXC）氢键型药物在该双水相体系中的分配行为。

The extraction behaviours of two hydrogen bonding drugs hydroxybenzoic acid ( APC ) and lomefloxacin ( LFXC ) were carried out in this system .

洛美沙星联合治疗耐多药肺结核近期疗效观察

Outcomes of patients with multidrug-resistant pulmonary tuberculosis Treated With Lomefloxacin-Containing Regimens

洛美沙星注射液治疗急性细菌感染110例

Lomefloxacin injection in treatment of 110 patients with acute bacterial infections

司帕沙星与洛美沙星片剂临床疗效及安全性的比较

A comparison on clinical efficacy and safety of sparfloxacin and lomefloxacin

玻碳电极伏安法测定洛美沙星

Determination of Lomefloxacin on Glassy Carbon Electrode with Cyclic Voltammetry

国产盐酸洛美沙星治疗124例泌尿系感染

Domestic lomefloxacin in the treatment of 124 Cass of urinary tract infection

洛美沙星透皮吸收搽剂的稳定性研究

Study on Stability of Lomefloxacin Liniment of Transdermal Absorbent Preparation

洛美沙星与环丙沙星治疗下呼吸道感染的疗效观察

Effect of lomefloxacin and ciprofloxacin on patients with lower respiratory tract infections

洛美沙星的人血清蛋白结合率为16.3%。

About 16.3 % lomefloxacin was protein bound in serum .

目的考察盐酸洛美沙星注射液与73种注射剂配伍变化结果。

Compatibility Results of Lomefloxacin Hydrochloride Injection and73 kinds of Injectable Drugs ;

血清中盐酸洛美沙星的测定及荧光光谱特性

Determination of Lomefloxacin Hydrochloride in Serum and Fluorescence Spectrum Characteristic

目的：研制洛美沙星泡腾片并建立质量标准。

Objective : To prepare Lomefloxacin effervescent tablet and establish quality specifications .

复方洛美沙星栓的研制与临床应用

Trituration and Clinical Application of Compound Suppository of Lomefloxacin